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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Meiosis expressed gene 1

MEIG1, meg1, PP4R1
Top mentioned proteins: PPX, CAN, E3 ubiquitin ligase, HAD, AP-1
Papers on MEIG1
Dissecting the structural basis of MEIG1 interaction with PACRG.
New
Zhang et al., Wuhan, China. In Sci Rep, Dec 2015
The product of the meiosis-expressed gene 1 (MEIG1) is found in the cell bodies of spermatocytes and recruited to the manchette, a structure unique to elongating spermatids, by Parkin co-regulated gene (PACRG).
Lentivirus-Mediated Short-Hairpin RNA Targeting Protein Phosphatase 4 Regulatory Subunit 1 Inhibits Growth in Breast Cancer.
New
Ye et al., Ningde, China. In J Breast Cancer, Sep 2015
PURPOSE: Protein phosphatase 4 regulatory subunit 1 (PP4R1), as an interaction partner of the catalytic serine/threonine-protein phosphatase 4 catalytic subunit has been shown to involve in cellular processes and nuclear factor κB signaling.
A MEIG1/PACRG complex in the manchette is essential for building the sperm flagella.
New
Zhang et al., Richmond, United States. In Development, Apr 2015
Yeast two-hybrid studies revealed that meiosis-expressed gene 1 (MEIG1) and Parkin co-regulated gene (PACRG) interact, and that sperm-associated antigen 16, which encodes an axoneme central apparatus protein, is also a binding partner of MEIG1.
Characterization of membrane occupation and recognition nexus repeat containing 3, meiosis expressed gene 1 binding partner, in mouse male germ cells.
Zhang et al., Wuhan, China. In Asian J Androl, 2015
Meiosis expressed gene 1 (MEIG1) plays an essential role in the regulation of spermiogenesis.
The PP4R1 subunit of protein phosphatase PP4 targets TRAF2 and TRAF6 to mediate inhibition of NF-κB activation.
Hatzivassiliou et al., Thessaloníki, Greece. In Cell Signal, 2014
A yeast two-hybrid screen with TRAF2 as bait, identified the regulatory subunit PP4R1 of protein phosphatase PP4 as a TRAF2-interacting protein.
PP4R1 accelerates cell growth and proliferation in HepG2 hepatocellular carcinoma.
Liu et al., Shanghai, China. In Onco Targets Ther, 2014
Besides, previous studies have identified protein phosphatase 4 regulatory subunit 1 (PP4R1) as a constitutive interaction partner of PP4 catalytic subunit PP4C.
The mouse transcription factor-like 5 gene encodes a protein localized in the manchette and centriole of the elongating spermatid.
Zhang et al., Wuhan, China. In Andrology, 2013
Meig1 is one of many genes involved in the regulation of this process.
Germ cell-specific disruption of the Meig1 gene causes impaired spermiogenesis in mice.
Zhang et al., Richmond, United States. In Andrology, 2013
Meiosis expressed gene 1 (Meig1) was originally identified in a search for mammalian genes potentially involved in meiosis.
The taming of the NF-κB: PP4R1 navigates while PP4c dephosphorylates.
Impact
Aifantis et al., New York City, United States. In Immunity, 2012
In this issue of Immunity, Brechmann et al. (2012) identify a phosphatase, PP4R1, that inhibits NF-κB activation in T cells and T cell lymphoma.
A PP4 holoenzyme balances physiological and oncogenic nuclear factor-kappa B signaling in T lymphocytes.
Impact
Arnold et al., Heidelberg, Germany. In Immunity, 2012
By RNAi screening, we have identified protein phosphatase 4 regulatory subunit 1 (PP4R1) as a negative regulator of NF-κB activity in T lymphocytes.
Efficient typing of copy number variations in a segmental duplication-mediated rearrangement hotspot using multiplex competitive amplification.
Zhang et al., Shanghai, China. In J Hum Genet, 2012
Recently, two independent studies showed that the murine meiosis expressed gene 1 (Meig1) was critical to spermatogenesis.
Gene expression alterations by conditional knockout of androgen receptor in adult Sertoli cells of Utp14b jsd/jsd (jsd) mice.
Meistrich et al., Houston, United States. In Biol Reprod, 2011
Surprisingly, a set of germ cell–specific genes preferentially expressed in differentiated spermatogonia and meiotic cells, including Meig1, Sycp3, and Ddx4, were all upregulated about 2-fold in SCARKO-jsd testes.
Gene expression alterations by conditional knockout of androgen receptor in adult sertoli cells of Utp14b(jsd/jsd) (jsd) mice.
Meistrich et al., Houston, United States. In Biol Reprod, 2010
Surprisingly, a set of germ cell-specific genes preferentially expressed in differentiated spermatogonia and meiotic cells, including Meig1, Sycp3, and Ddx4, were all upregulated about 2-fold in SCARKO-jsd testes.
Copy number variants in premature ovarian failure and ovarian dysgenesis.
Wieacker et al., Münster, Germany. In Sex Dev, 2010
IMMP2L, FER1L6, MEIG1).
Meig1 deficiency causes a severe defect in mouse spermatogenesis.
GeneRIF
Don et al., Ramat Gan, Israel. In Dev Biol, 2010
late spermiogenesis is the differentiative stage at which MEIG1's function is crucial
MEIG1 is essential for spermiogenesis in mice.
GeneRIF
Strauss et al., Richmond, United States. In Proc Natl Acad Sci U S A, 2009
Findings reveal a critical role for the MEIG1/PARCG partnership in manchette structure and function and the control of spermiogenesis.
Tissue expression patterns identify mouse cilia genes.
GeneRIF
Bergman et al., Lexington, United States. In Physiol Genomics, 2008
Meig1 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
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