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Protein tyrosine phosphatase, non-receptor type 4

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, thrombopoietin, HAD, ACID, CsF
Papers on Meg
Effects of panaxadiol saponins component as a new Chinese patent medicine on proliferation, differentiation and corresponding gene expression profile of megakaryocytes.
Yin et al., Hangzhou, China. In Chin J Integr Med, Jan 2016
METHODS: Bone marrow culture of colony forming assay of megakaryocytic progenitor cells (CFU-MK) was observed for the promoting proliferation mediated by PDS-C, and differentiation of megakaryocytic blasts caused by PDS-C was analyzed with flow cytometry in CHRF-288 and Meg-01 cells, as well as proliferation, differentiation-related genes expression profile and protein expression levels were detected by human gene expression microarray and western blot.
Association of membrane/lipid rafts with the platelet cytoskeleton and the caveolin PY14: participation in the adhesion process.
Winder et al., Mexico. In J Cell Biochem, Nov 2015
We transfected a megakaryoblast cell line (Meg-01) to deplete β-dystroglycan, subsequent to their differentiation to the platelet progenitors.
High resolution mass spectrometry based profiling of diet-related deoxyribonucleic acid adducts.
Vanhaecke et al., Merelbeke, Belgium. In Anal Chim Acta, Oct 2015
Four targeted DNA adducts, which all have been linked to dietary genotoxicity, were included in the described method; O(6)-methylguanine (O(6)-MeG), O(6)-carboxymethylguanine (O(6)-CMG), pyrimidopurinone (M1G) and methylhydroxypropanoguanine (CroG).
Human megakaryocytes confer tissue factor to a subset of shed platelets to stimulate thrombin generation.
Camera et al., Milano, Italy. In Thromb Haemost, Oct 2015
In order to avoid the cross-talk with circulating microparticles, we took advantage from an in vitro cultured megakaryoblastic cell line (Meg-01) able to differentiate into megakaryocytes releasing platelet-like particles.
Design, synthesis and antiviral evaluation of 2'-C-methyl branched guanosine pronucleotides: the discovery of IDX184, a potent liver-targeted HCV polymerase inhibitor.
Gosselin et al., Montpellier, France. In Future Med Chem, Sep 2015
Results/methodology: In this article, the authors detail the synthesis, anti-HCV evaluation in cell-based replicon assays and structure-activity relationships of several phosphoramidate diester derivatives of 2'-C-methylguanosine (2'-MeG).
Inhibition of glutamate regulated calcium entry into leukemic megakaryoblasts reduces cell proliferation and supports differentiation.
Kalev-Zylinska et al., Auckland, New Zealand. In Cell Signal, Sep 2015
Three human cell lines, Meg-01, Set-2 and K-562 were used as models of leukemic megakaryoblasts.
Single-Cell Network Analysis Identifies DDIT3 as a Nodal Lineage Regulator in Hematopoiesis.
Enver et al., London, United Kingdom. In Cell Rep, Jul 2015
RNA sequencing suggests that Ddit3 acts through development or stabilization of a precursor upstream of GMPs with inherent Meg-E potential.
The bacterial alkyltransferase-like (eATL) protein protects mammalian cells against methylating agent-induced toxicity.
Kaina et al., Mainz, Germany. In Dna Repair (amst), Apr 2015
In both pro- and eukaryotes, the mutagenic and toxic DNA adduct O(6)-methylguanine (O(6)MeG) is subject to repair by alkyltransferase proteins via methyl group transfer.
Triazene compounds in the treatment of acute myeloid leukemia: a short review and a case report.
Aquino et al., Roma, Italy. In Curr Med Chem, 2012
The triazene compounds Dacarbazine and Temozolomide are monofunctional alkylators that donate methyl groups to many sites in DNA, including the O(6)-position of guanine producing O(6)-methylguanine (O(6)-MeG).
The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions.
van Oers et al., Dallas, United States. In Mol Immunol, 2008
PTPN4 is dispensable for T cell development and/or T cell effector functions.
MLLT3 regulates early human erythroid and megakaryocytic cell fate.
Enver et al., Oxford, United Kingdom. In Cell Stem Cell, 2008
Through expression profiling of prospectively isolated stem and primitive progenitor cells as well as committed progenitors from cord blood (CB), we identified MLLT3 as a candidate regulator of erythroid/megakaryocytic (E/Meg) lineage decisions.
MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents.
Roos et al., Mainz, Germany. In Dna Repair (amst), 2007
Experimental systems, in which MGMT has been modulated, revealed that O(6)-methylguanine (O(6)MeG) and O(6)-chloroethylguanine are major mutagenic, carcinogenic, recombinogenic, clastogenic and killing lesions.
Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia.
Castilla et al., Worcester, United States. In Cancer Cell, 2006
In addition, Cbf beta-SMMHC blocked megakaryocytic maturation at the CFU-Meg to megakaryocyte transition.
DNA alkylation and repair in the large bowel: animal and human studies.
Margison et al., Manchester, United Kingdom. In J Nutr, 2002
O6-methylguanine (O6-MeG), a procarcinogenic DNA adduct that arises from exposure to methylating agents, has been detected in human colorectal DNA at levels comparable to those that cause adverse effects in model systems.
The effects of arsenic trioxide (As2O3) on human megakaryocytic leukemia cell lines. With a comparison of its effects on other cell lineages.
Levin et al., Paris, France. In Leuk Lymphoma, 2000
At pharmacological concentrations (0.5-2 microM) As2O3 selectively inhibits growth and causes apoptosis in the megakaryocytic leukemia cell lines HEL, Meg-01, UT7 and M07e.
Gene transfer to suppress bone marrow alkylation sensitivity.
Samson et al., Boston, United States. In Mutat Res, 2000
One strategy to overcome bone marrow sensitivity to alkylating agent exposure involves gene transfer of the DNA repair protein O(6)-methylguanine DNA methyltransferase (O(6)MeG DNA MTase) into bone marrow cells.
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