A functional portrait of Med7 and the mediator complex in Candida albicans.
Montréal, Canada. In Plos Genet, 2014
Intriguingly, while the Med4, 8, 10, 11, 14, 17, 21 and 22 subunits were essential in both fungi, the structurally highly conserved Med7 subunit was apparently non-essential in C. albicans.
Characterization of the influence of mediator complex in HIV-1 transcription.
Badalona, Spain. In J Biol Chem, 2014
Knockdown of 9 out of 28 human MED proteins significantly impaired viral replication without affecting cell viability, including MED6, MED7, MED11, MED14, MED21, MED26, MED27, MED28, and MED30.
MC EMiNEM maps the interaction landscape of the Mediator.
München, Germany. In Plos Comput Biol, 2011
We identify the N-terminus of Med7 as a peripheral entity, entailing only local structural changes upon perturbation, while the C-terminus of Med7 and Med19 appear to play a central role.
Mediator influences telomeric silencing and cellular life span.
Göteborg, Sweden. In Mol Cell Biol, 2011
Loss of the Mediator Med5 subunit or mutations in Med7 cause a depletion of the complex from regions located near subtelomeric X elements, which leads to a change in the balance between the Sir2 and Sas2 proteins.
Preparation and topology of the Mediator middle module.
München, Germany. In Nucleic Acids Res, 2010
Protein-protein interaction assays combined with previously published data suggest that the Med7 and Med4 subunits serve as a binding platform to form the three heterodimeric subcomplexes, Med7N/21, Med7C/31 and Med4/9.