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Protocadherin gamma subfamily B, 7

Me-6, GPR64
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, Malate Dehydrogenase, ACID, TFE
Papers on Me-6
The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration.
New
Schwartz et al., Copenhagen, Denmark. In Cell Signal, Dec 2015
ADGRG2 (or GPR64) which originally was described to be expressed in the epididymis and studied for its potential role in male fertility, is highly up-regulated in a number of carcinomas, including breast cancer.
Trimethylaluminum: Bonding by Charge and Current Topology.
New
Mitzel et al., Bielefeld, Germany. In Angew Chem Int Ed Engl, Dec 2015
The data can be interpreted as Al2 Me6 being predominantly ionically bonded, with clear indications of topological asymmetry for the bridging AlC bonds owing to delocalized multicenter bonding.
Developing lithium chemistry of 1,2-dihydropyridines: from kinetic intermediates to isolable characterized compounds.
New
Robertson et al., Glasgow, United Kingdom. In Chemistry, Nov 2015
Emphasizing the criticalness of stoichiometry, reaction of nBuLi/Me6 TREN with two equivalents of pyridine results in non-alkylated 1-lithio-1,4-dihydropyridine⋅Me6 TREN and 2-n-butylpyridine, implying mechanistically the kinetic 1,2-n-butyl intermediate hydrolithiates the second pyridine.
Carbon Monoxide Addition to Ruthenium-Dithiolene Complex and Polysiloxane Hybrid Film Formation.
New
Gunji et al., Noda, Japan. In Chem Asian J, Sep 2015
The addition of carbon monoxide to the ruthenium center of [(η(6) -C6 Me6 )Ru(S2 C6 H4 )] (1) has been investigated.
Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2.
New
Liebscher et al., Leipzig, Germany. In Biochem Biophys Res Commun, Sep 2015
The epididymis-specific adhesion G protein-coupled receptor (aGPCR) GPR64/ADGRG2 has been shown to be a key-player in the male reproductive system.
P,O-Phosphinophenolate zinc(II) species: synthesis, structure and use in the ring-opening polymerization (ROP) of lactide, ε-caprolactone and trimethylene carbonate.
New
Dagorne et al., Caparica, Portugal. In Dalton Trans, Aug 2015
The P,O-type phosphinophenol proligands (1·H, 2-PPh2-4-Me-6-Me-C6H2OH; 2·H, 2-PPh2-4-Me-6-(t)Bu-C6H2OH) readily react with one equiv.
Ligand field influence on the electronic and magnetic properties of quasi-linear two-coordinate iron(II) complexes.
New
Power et al., Manchester, United Kingdom. In Dalton Trans, Jul 2015
Ab initio calculations of the CASSCF/RASSI/SINGLE-ANISO type have indicated that the orbital energies of the complexes, as well as those of Fe(Ar(Me6))2, 4, where Ar(Me6) is C6H3-2,6(C6H2-2,4,6-Me3)2), are in the order d(xy)≈ d(x(2)-y(2)) < d(xz) ≈ d(yz) < d(z(2)), and the iron(II) complexes in this ligand field have the (d(xy), d(x(2)-y(2)))(3)(d(xz), d(yz))(2)(d(z(2)))(1) ground electronic configuration with a substantial orbital contribution to their effective magnetic moments.
Syntheses of Mononuclear and Dinuclear Aluminum Complexes Stabilized by Phenolato Ligands and Their Applications in the Polymerization of ε-Caprolactone: A Comparative Study.
New
Yao et al., Suzhou, China. In Inorg Chem, Jun 2015
In order to compare the catalytic activities of these bimetallic complexes with their mononuclear counterparts, mono(phenolato) aluminum complexes AlMe2[ON](1) (7), AlMe2[ON](2) (8), AlMe2[ON](3) (9), AlEt2[ON](2) (10), and AlEt2[ON](3) (11) were synthesized from reactions of 1 equiv of AlMe3 or 2 equiv of AlEt3 with phenols that bear piperidine moieties, i.e., [2-(CH2NC5H10)-4,6-Me2-C6H2OH (H[NO](1)), 2-(CH2NC5H10)-4-Me-6-(t)Bu-C6H2OH (H[NO](2)), and 2-(CH2NC5H10)-4,6-(t)Bu2-C6H2OH (H[NO](3))], respectively.
Photo-induced living radical polymerization of acrylates utilizing a discrete copper(II)-formate complex.
New
Haddleton et al., Warwick, United Kingdom. In Chem Commun (camb), May 2015
A photo-polymerization protocol, utilizing a pre-formed and well-characterized Cu(II) formate complex, [Cu(Me6-Tren)(O2CH)](ClO4), mediated by UV light is described.
Addition of ethylene or hydrogen to a main-group metal cluster under mild conditions.
New
Power et al., Jyväskylä, Finland. In Angew Chem Int Ed Engl, Apr 2015
Reaction of the tin cluster Sn8(Ar(Me6))4(Ar(Me6)=C6H2-2,6-(C6H3-2,4,6-Me3)2) with excess ethylene or dihydrogen at 25 °C/1 atmosphere yielded two new clusters that incorporated ethylene or hydrogen.
Reaction of a germylene, stannylene, or plumbylene with trimethylaluminum and trimethylgallium: insertion into Al-C or ga-C bonds, a reversible metal-carbon insertion equilibrium, and a new route to diplumbenes.
New
Power et al., Davis, United States. In Inorg Chem, Mar 2015
The reaction of the tetrylenes Ge(Ar((Me)6))2, Sn(Ar((Me)6))2, and Pb(Ar((Me)6))2 [Ar((Me)6) = C6H3-2,6-(C6H2-2,4,6-(CH3)3)2] with the group 13 metal alkyls trimethylaluminum and trimethylgallium afforded (Ar((Me)6))2Ge(Me)AlMe2 (1), (Ar((Me)6))2Ge(Me)GaMe2 (2), and (Ar(Me6))2Sn(Me)GaMe2 (3) in good yields via insertion reaction routes.
International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.
Review
Impact
Schiöth et al., Amsterdam, Netherlands. In Pharmacol Rev, 2014
The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98).
Adhesion-GPCRs in the male reproductive tract.
Review
Kirchhoff et al., Oxford, United Kingdom. In Adv Exp Med Biol, 2009
Gpr64 is the best characterised of the adhesion-GPCRs in the male reproductive system and the phenotype of Gpr64 knock-out mice implicates this receptor in the regulation of fluid absorption in the efferent ducts and proximal epididymis.
Novel epididymal proteins as targets for the development of post-testicular male contraception.
Review
Poutanen et al., Turku, Finland. In Reproduction, 2009
These proteins include CRISP1, SPAG11e, DEFB126, carbonyl reductase P34H, CD52, and GPR64.
Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors.
GeneRIF
van Wijnen et al., Worcester, United States. In J Biol Chem, 2008
Affymetrix expression profiling shows that the C terminus of Runx2 regulates genes involved in G protein-coupled receptor signaling Rgs2, Rgs4, Rgs5, Rgs16, Gpr23, Gpr30, Gpr54, Gpr64, and Gna13.
Novel epididymis-specific mRNAs downregulated by HE6/Gpr64 receptor gene disruption.
GeneRIF
Kirchhoff et al., Hamburg, Germany. In Mol Reprod Dev, 2007
The knockout of the HE6/Gpr64 receptor was mainly associated with the downregulation of genes specific to the initial segment.
Role of epididymal receptor HE6 in the regulation of sperm microenvironment.
Review
Davies et al., Hamburg, Germany. In Mol Cell Endocrinol, 2006
HE6 (GPR64) is a highly conserved, tissue-specific heptahelical receptor of the human epididymis.
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