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MDV1 Mdv1p

Mdv1, Mdv1p, GAG3, NET2, TSPAN12
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: HAD, CAN, ACID, GPCR, AGE
Papers on Mdv1
Exome Sequencing on 298 Probands With Early-Onset High Myopia: Approximately One-Fourth Show Potential Pathogenic Mutations in RetNet Genes.
Zhang et al., In Invest Ophthalmol Vis Sci, Jan 2016
Of the 71 probands, 44 (62.0%) had mutations in 11 genes responsible for ocular diseases accompanied by high myopia, including COL2A1, COL11A1, PRPH2, FBN1, GNAT1, OPA1, PAX2, GUCY2D, TSPAN12, CACNA1F, and RPGR.
Activation of Toll-like receptor 3 inhibits Marek's disease virus infection in chicken embryo fibroblast cells.
Ye et al., Yangzhou, China. In Arch Virol, Dec 2015
In addition, we found that the expression trend of TLR3 mRNA in RB1B-infected CEF cells was similar to that of mdv1-mir-M4-5p (a functional ortholog of oncogenic miR-155 encoded by MDV).
Molecular Characterization of FZD4, LRP5, and TSPAN12 in Familial Exudative Vitreoretinopathy.
Kim et al., Seoul, South Korea. In Invest Ophthalmol Vis Sci, Aug 2015
The genes FZD4, LRP5, and TSPAN12 are known to be associated with the autosomal inheritance form of FEVR.
Familial exudative vitreoretinopathy and related retinopathies.
Gilmour, Leeds, United Kingdom. In Eye (lond), 2015
Five genes have been identified that when mutated, cause FEVR; NDP (X-linked), FZD4 (autosomal dominant and recessive), LRP5 (autosomal dominant and recessive), TSPAN12 (autosomal dominant and recessive), and ZNF408 (autosomal dominant).
Parent Artery Occlusion for Unruptured Cerebral Aneurysms: The Japanese Registry of Neuroendovascular Therapy (JR-NET) 1 and 2.
Japanese Registry of Neuroendovascular Therapy (JR-NET) investigators et al., In Neurol Med Chir (tokyo), 2013
In the present study, a total of 381 consecutive patients with unruptured cerebral aneurysms who were treated with PAO were extracted from the Japanese Registry of Neuroendovascular Therapy (JR-NET) 1 and JR-NET2 database, which are nationwide surveys conducted by the Japanese Society of Neuroendovascular Therapy.
Endovascular Treatment of Spinal Vascular Lesion in Japan: Japanese Registry of Neuroendovascular Therapy (JR-NET) and JR-NET2.
Sakai et al., In Neurol Med Chir (tokyo), 2013
A subgroup analysis of spinal vascular lesions in the Japanese Registry of Neuroendovascular Therapy (JR-NET) and JR-NET2, retrospective registry studies conducted in 2005–2009, was performed to understand the current status of treatment in Japan.
Role of virus-encoded microRNAs in Avian viral diseases.
Nair et al., Compton, United States. In Viruses, 2013
For example, mdv1-miR-M4-5p, a functional ortholog of gga-miR-155, is critical for the oncogenicity of Marek's disease virus.
Real-world Experience of Carotid Artery Stentingin Japan: Analysis of 7,134 Cases from JR-NET1 and 2Nationwide Retrospective Multi-center Registries.
Japanese Registry of Neuroendovascular Therapy (JR-NET) investigators et al., In Neurol Med Chir (tokyo), 2013
A total of 7,134 procedures (1,943 for JR-NET1 and 5,191 for JR-NET2) were included in this study and retrieved data were analyzed retrospectively.
Current Status of Endovascular Treatment for Vasospasm following Subarachnoid Hemorrhage: Analysis of JR-NET2.
JR-NET2 study group et al., In Neurol Med Chir (tokyo), 2013
Here, we analyzed the data of Japanese Registry of Neuroendovascular Therapy 2 (JR-NET2) and revealed current status of the endovascular treatment for the cerebral vasospasm.
Endovascular Treatment for Ruptured Vertebral Artery Dissecting Aneurysms: Results from Japanese Registry of Neuroendovascular Therapy (JR-NET) 1 and 2.
JR-NET study group et al., In Neurol Med Chir (tokyo), 2013
A total of 213 in JR-NET1 and 381 patients in JR-NET2 with ruptured VADA were included, and they were separately analyzed because several important datasets such as vasospasm and site of dissecting aneurysms in relation to the posterior inferior cerebellar artery (PICA) were collected only in JR-NET1.
[Retinal exudative disease in childhood: Coats' disease and familial exudative vitreoretinopathy (FEVR)].
Müller et al., Franklin, United States. In Klin Monbl Augenheilkd, 2013
FEVR inheritance is 56 % dominant (FZD4 und TSPAN12) and 44 % recessive (LRP5 und NDP).
Current state of Marek's disease virus microRNA research.
Liu et al., Raleigh, United States. In Avian Dis, 2013
For example, mdv1-miR-M4 and mdv1-miR-M2-3p are three- and sixfold higher, expressed, respectively, in vv+ strains compared to vv strains.
Recessive mutations in TSPAN12 cause retinal dysplasia and severe familial exudative vitreoretinopathy (FEVR).
Toomes et al., Leeds, United Kingdom. In Invest Ophthalmol Vis Sci, 2012
This study is the first report of recessive mutations in TSPAN12 and shows that patients with two mutant alleles have a severe form of FEVR or retinal dysplasia, whereas heterozygous family members have mild familial exudative vitreoretinopathy phenotypes
Norrin: molecular and functional properties of an angiogenic and neuroprotective growth factor.
Tamm et al., Regensburg, Germany. In Prog Retin Eye Res, 2012
Norrin specifically binds to Frizzled-4 receptors and activates the canonical Wnt/β-catenin signaling pathway that is profoundly enhanced when Tspan12 is present at the Norrin/Frizzled-4 receptor complex.
Crystal structure of mitochondrial fission complex reveals scaffolding function for mitochondrial division 1 (Mdv1) coiled coil.
Chan et al., Pasadena, United States. In J Biol Chem, 2012
in addition to dimerization, the unusually long Mdv1 coiled coil serves a scaffolding function to stabilize the Mdv1-Fis1 complex.
Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells.
Lukiw et al., New Orleans, United States. In Neurosci Lett, 2011
The largest miRNA-146a-TSPAN12 response to stress of amyloidbeta peptide + tumor necrosis factoralpha is found in human neuronal glial cells from Alzheimer brain.
Submicroscopic deletion in 7q31 encompassing CADPS2 and TSPAN12 in a child with autism spectrum disorder and PHPV.
Yamamoto et al., Ōsaka, Japan. In Am J Med Genet A, 2011
We speculate that haploinsufficiency of TSPAN12 contributes to PHPV.
Novel TSPAN12 mutations in patients with familial exudative vitreoretinopathy and their associated phenotypes.
Zhang et al., Guangzhou, China. In Mol Vis, 2010
TSPAN12 mutations are responsible for familial exudative vitreoretinopathy (FEVR). The phenotypes associated with TSPAN12 mutations showed great variations between different individuals within a family and between the two eyes in individual patients.
TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling.
Ye et al., San Francisco, United States. In Cell, 2009
Data indicate that Norrin multimers and TSPAN12 cooperatively promote multimerization of FZD4 and its associated proteins to elicit physiological levels of signaling.
A novel programed frameshift expresses the POL3 gene of retrotransposon Ty3 of yeast: frameshifting without tRNA slippage.
Vimaladithan et al., Baltimore, United States. In Cell, 1993
We describe here an unusual translational frameshift event occurring between the GAG3 and POL3 genes of the retrotransposon Ty3 of yeast.
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