Whole-genome characterization of chemoresistant ovarian cancer.
Brisbane, Australia. In Nature, Jun 2015
We observed several molecular events associated with acquired resistance, including multiple independent reversions of germline BRCA1 or BRCA2 mutations in individual patients, loss of BRCA1 promoter methylation, an alteration in molecular subtype, and recurrent promoter fusion associated with overexpression of the drug efflux pump MDR1.
Genetic susceptibility in childhood acute leukaemias: a systematic review.
Rio de Janeiro, Brazil. In Ecancermedicalscience, 2014
We observed that the most frequently investigated genes were: NQO1, GSTM1, GSTT1, GSTP1, CYP1A1, NAT2, CYP2D6, CYP2E1, MDR1 (ABCB1), XRCC1, ARID5B, and IKZF1.
Cytochrome P450 in living donor liver transplantation.
Kao-hsiung, Taiwan. In J Biomed Sci, 2014
The metabolizing isoenzyme of the major anti-rejection agents passes through CYP3A4, CYP3A5 and MDR1, which have also been identified to have similar biological characteristics as genotype of CYP2C19 in liver tissue.
A "silent" polymorphism in the MDR1 gene changes substrate specificity.
Bethesda, United States. In Science, 2007
We report that a synonymous SNP in the Multidrug Resistance 1 (MDR1) gene, part of a haplotype previously linked to altered function of the MDR1 gene product P-glycoprotein (P-gp), nonetheless results in P-gp with altered drug and inhibitor interactions.