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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

TBC1 domain family, member 9

Top mentioned proteins: CD45, Gp, CAN, HAD, POLYMERASE
Papers using MDR1 antibodies
Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model.
Datta Kaustubh, In PLoS ONE, 2007
... GST-π(3369), PARP(9532), Cleaved PARP(9541), and BAX were from Cell Signaling (Danvers, MA); TrkB(sc-8316), GSK-3b(sc-9166), and MDR1(sc-55510) were from Santa Cruz Biotechnology, Inc ...
Caspase-dependent cleavage of 170-kDa P-glycoprotein during apoptosis of human T-lymphoblastoid CEM cells
Wen Lei et al., In International Journal of Biological Sciences, 2005
... The phospho-glycoprotein (P-gp) MDR1 mouse monoclonal antibody and FITC-conjugated goat anti-mouse IgG were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA), ...
Papers on MDR1
Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation.
Gao et al., Nanning, China. In Acta Pharmacol Sin, Feb 2016
METHODS: Human umbilical vein endothelial cells (HUVECs) were treated with ginkgolide B. The expression of PXR, CYP3A4, MDR1, VCAM-1, E-selectin and caspase-3 were quantified with qRT-PCR and Western blot analysis.
Role of P-glycoprotein in mediating rivastigmine effect on amyloid-β brain load and related pathology in Alzheimer's disease mouse model.
Kaddoumi et al., Monroe, United States. In Biochim Biophys Acta, Feb 2016
APPSWE mice were bred with mdr1a/b knockout mice to produce littermates that were divided into three groups; APP(+)/mdr1(+/+), APP(+)/mdr1(+/-) and APP(+)/mdr1(-/-).
RANK-RANKL interactions are involved in cell adhesion-mediated drug resistance in multiple myeloma cell lines.
Nishida et al., Ōsaka, Japan. In Tumour Biol, Feb 2016
RANKL stimulation of RANK-expressing cells increased multidrug resistance protein 1 (MDR1), breast cancer resistance protein (BCRP), and lung resistance protein 1 (LRP1) expression and decreased Bim expression through various signaling molecules.
MRP3 as a novel resistance factor for sorafenib in hepatocellular carcinoma.
Takayama et al., Tokushima, Japan. In Oncotarget, Feb 2016
Likewise, when expression of membrane transporter proteins was determined, there were no significant differences in expression levels of BSEP, MDR1, MRP2, BCRP, MRP4 and OCT1 between resistant clones and parent cells.
Thermal proteome profiling monitors ligand interactions with cellular membrane proteins.
Drewes et al., Heidelberg, Germany. In Nat Methods, Dec 2015
We also observed cellular thermal shifts in pervanadate-induced T cell-receptor signaling, delineating the membrane target CD45 and components of the downstream pathway, and with drugs affecting the transmembrane transporters ATP1A1 and MDR1.
Influence of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on expression of P-glycoprotein and cytochrome P450 3A in sheep.
Lifschitz et al., Hannover, Germany. In J Steroid Biochem Mol Biol, Sep 2015
UNASSIGNED: In order to improve calcium and phosphorus balance, beef cattle and dairy cows can be supplemented with vitamin D. However, different vitamin D metabolites have been shown to increase expression of P-glycoprotein (P-gp, MDR1, ABCB1) and cytochrome P450 3A (CYP3A) in rodents as well as in cell culture systems.
Whole-genome characterization of chemoresistant ovarian cancer.
Bowtell et al., Brisbane, Australia. In Nature, Jun 2015
We observed several molecular events associated with acquired resistance, including multiple independent reversions of germline BRCA1 or BRCA2 mutations in individual patients, loss of BRCA1 promoter methylation, an alteration in molecular subtype, and recurrent promoter fusion associated with overexpression of the drug efflux pump MDR1.
Genetic susceptibility in childhood acute leukaemias: a systematic review.
Pombo-de-Oliveira et al., Rio de Janeiro, Brazil. In Ecancermedicalscience, 2014
We observed that the most frequently investigated genes were: NQO1, GSTM1, GSTT1, GSTP1, CYP1A1, NAT2, CYP2D6, CYP2E1, MDR1 (ABCB1), XRCC1, ARID5B, and IKZF1.
Cytochrome P450 in living donor liver transplantation.
Chen et al., Kao-hsiung, Taiwan. In J Biomed Sci, 2014
The metabolizing isoenzyme of the major anti-rejection agents passes through CYP3A4, CYP3A5 and MDR1, which have also been identified to have similar biological characteristics as genotype of CYP2C19 in liver tissue.
Evaluating Potential P-gp Substrates: Main Aspects to Choose the Adequate Permeability Model for Assessing Gastrointestinal Drug Absorption.
dos Reis Serra et al., São Paulo, Brazil. In Mini Rev Med Chem, 2014
In an initial planning, MDCK-MDR1 tend to be the chosen method for efflux studies due its ability of express P-gp, followed by studies conducted in Caco-2 models.
Bypassing P-Glycoprotein Drug Efflux Mechanisms: Possible Applications in Pharmacoresistant Schizophrenia Therapy.
Pillay et al., Johannesburg, South Africa. In Biomed Res Int, 2014
The overexpression of the MDR1 P-glycoprotein has been related to the occurrence of multidrug resistance in CNS diseases.
Relationships of related genetic polymorphisms and individualized medication of tacrolimus in patients with renal transplantation.
Lin et al., Nanjing, China. In Int J Clin Exp Med, 2014
The genetic polymorphisms of CYP3A4, CYP3A5 and MDR1 in 216 RT patients were detected by PCR-RFLP, the genetic and clinical factors and blood concentration/dose × body weight (C/D) values of tacrolimus were performed the single factor correlation analysis, and established the dose prediction algorithm of tacrolimus by stepwise multiple regression analysis.
MDR1 gene C3435T polymorphism is associated with clinical outcomes in gastric cancer patients treated with postoperative adjuvant chemotherapy.
Li et al., Nanjing, China. In Asian Pac J Cancer Prev, 2010
The MDR1 gene CT/TT genotype of C3435T was significantly associated with a shorter progression-free survival (PFS) and overall survival (OS).
Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis.
Sabatine et al., Boston, United States. In Lancet, 2010
BACKGROUND: Clopidogrel and prasugrel are subject to efflux via P-glycoprotein (encoded by ABCB1, also known as MDR1).
CD34+ leukemic subpopulation predominantly displays lower spontaneous apoptosis and has higher expression levels of Bcl-2 and MDR1 genes than CD34- cells in childhood AML.
Aleinikova et al., Minsk, Belarus. In Ann Hematol, 2008
CD34+ leukemic subpopulation predominantly displays lower spontaneous apoptosis and has higher expression levels of MDR19TBC1 domain family member 9 (with GRAM domain) ) genes than CD34- cells in childhood AML
A "silent" polymorphism in the MDR1 gene changes substrate specificity.
Gottesman et al., Bethesda, United States. In Science, 2007
We report that a synonymous SNP in the Multidrug Resistance 1 (MDR1) gene, part of a haplotype previously linked to altered function of the MDR1 gene product P-glycoprotein (P-gp), nonetheless results in P-gp with altered drug and inhibitor interactions.
Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system.
Váradi et al., Budapest, Hungary. In Physiol Rev, 2006
We treat in detail the biochemistry, cell biology, and physiology of the ABCB1 (MDR1/P-glycoprotein) and the ABCG2 (MXR/BCRP) proteins and describe emerging information related to additional ABCB- and ABCG-type transporters with a potential role in drug and xenobiotic resistance.
Plasma levels of atazanavir and the risk of hyperbilirubinemia are predicted by the 3435C-->T polymorphism at the multidrug resistance gene 1.
Soriano et al., Madrid, Spain. In Clin Infect Dis, 2006
Plasma levels of atazanavir were significantly higher in patients with MDR1 genotype CC than in those with CT or TT, and bilirubin levels correlated with atazanavir concentrations.
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