Rho GTPases in erythroid maturation.
Cincinnati, United States. In Curr Opin Hematol, 2014
mDia2, a Rho effector known to play a role in enucleation, was also found essential for erythroblast cytokinesis as its deficiency in mice caused failure of primitive erythropoiesis and embryonic death.
Filopodia are required for cortical neurite initiation.
Cambridge, United States. In Nat Cell Biol, 2007
Here, we report that neuritogenesis in Ena/VASP-null neurons can be rescued by restoring filopodia formation through ectopic expression of the actin nucleating protein mDia2.
RhoD, Src, and hDia2C in endosome motility.
Bethesda, United States. In Dev Cell, 2003
A recent report from Marino Zerial and colleagues examining RhoD identifies mDia2C, a novel splice variant of mDia2, and Src as components of the regulatory machinery influencing actin-dependent endosome movement.