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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Malate dehydrogenase 2, NAD

MDH, MDH1, cytosolic malate dehydrogenase
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, fibrillin-1, V1a
Papers on MDH
Activation of medullary dorsal horn PKCγ Interneurons is essential to the development of both static and dynamic facial mechanical allodynia.
New
Artola et al., Clermont-Ferrand, France. In Eur J Neurosci, Feb 2016
UNASSIGNED: The γ isoform of protein kinase C (PKCγ) which is concentrated in a specific class of interneurons within inner lamina II (IIi) of the spinal and medullary (MDH) dorsal horns is known to be involved in the development of mechanical allodynia, a widespread and intractable symptom of inflammatory or neuropathic pain.
Protein Kinase C γ Interneurons Mediate C-fiber-induced Orofacial Secondary Static Mechanical Allodynia, but Not C-fiber-induced Nociceptive Behavior.
New
Dallel et al., Clermont-Ferrand, France. In Anesthesiology, Feb 2016
METHODS: Combining behavioral, immunohistochemical, and Western blot analysis, the authors investigated the cell and molecular mechanisms underlying the secondary static mechanical allodynia in the rat medullary dorsal horn (MDH) using the capsaicin model (n = 4 to 5 per group).
N-terminal arm of orchardgrass Hsp17.2 (DgHsp17.2) is essential for both in vitro chaperone activity and in vivo thermotolerance in yeast.
New
Son et al., Chinju, South Korea. In Arch Biochem Biophys, Jan 2016
Its function in in vitro chaperone properties has shown in protecting the model substrate, malate dehydrogenase (MDH) and citrate synthase (CS).
Characterization of a human isolate of Tritrichomonas foetus (cattle/swine genotype) infected by a zoonotic opportunistic infection.
New
Iwata et al., Tokyo, Japan. In J Vet Med Sci, Jan 2016
rDNA-ITS2 region, the cysteine protease (CP)-1, CP-2 and CP-4 to CP-9 genes, and the cytosolic malate dehydrogenase 1 gene.
The enhanced lipid accumulation in oleaginous microalga by the potential continuous nitrogen-limitation (CNL) strategy.
New
Wang et al., Xiangtan, China. In Bioresour Technol, Jan 2016
Furthermore, the identified lipid accumulation-related metabolic checkpoints (MDH and GPDH) provide the possibilities to develop high-lipid engineering microalgae.
Migratory preparation associated alterations in pectoralis muscle biochemistry and proteome in Palearctic-Indian emberizid migratory finch, red-headed bunting, Emberiza bruniceps.
New
Chaturvedi et al., Benares, India. In Comp Biochem Physiol Part D Genomics Proteomics, Dec 2015
We studied how the serum metabolites (urea, uric acid, and creatinine), pectoralis muscle metabolites (glycogen, glucose, and cholesterol), muscle metabolic enzymes (CPT, HOAD, CS, MDH, CCO, CK, LDH, PFK, MLPL, and PK), liver lipogenic enzyme (FAS), and pectoralis muscle proteins get altered in pre-migratory and non-migratory buntings.
[Extracellular splitting pattern of mitochondria and the depressant effects of CsA on the process].
New
Sun et al., In Zhongguo Gu Shang, Nov 2015
COX and MDH were assayed by ELISA every 30 min.
Adaptations of protein structure and function to temperature: there is more than one way to 'skin a cat'.
Review
New
Somero et al., Lancaster, United States. In J Exp Biol, Jun 2015
A series of studies using two structurally and catalytically related enzymes, A4-lactate dehydrogenase (A4-LDH) and cytosolic malate dehydrogenase (cMDH) have been especially valuable in determining the functional attributes of enzymes most sensitive to temperature, and identifying amino acid substitutions that lead to changes in those attributes.
Gender-specific effects of intrauterine growth restriction on the adipose tissue of adult rats: a proteomic approach.
Ribeiro et al., São Paulo, Brazil. In Proteome Sci, 2014
The restricted males showed up-regulated levels of proteasome subunit α type 3, branched-chain-amino-acid aminotransferase, elongation 1- alpha 1, fatty acid synthase levels, cytosolic malate dehydrogenase and ATP synthase subunit alpha.
Effects of different dwarfing interstocks on key enzyme activities and the expression of genes related to malic acid metabolism in Red Fuji apples.
Xu et al., Baoding, China. In Genet Mol Res, 2014
The malate dehydrogenase (NAD-MDH) activity in apples on interstock No. 53 was highest on Day 30, Day 100, and Day 160 after bloom, and the malic enzyme (NADP-ME) activity in apples on interstock No. 111 was higher than in the interstock No. 53 fruit from Day 70 to Day 100 after bloom.
Identification of mutant genes with high-frequency, high-risk, and high-expression in lung adenocarcinoma.
Mei et al., Shanghai, China. In Thorac Cancer, 2014
At fragments per kilobase per million reads (FPKM) ≥ 56.5, reported tumor suppressor genes catenin (cadherin-associated protein), delta (CTNND)1, dual specificity phosphatase (DUSP)6, malate dehydrogenase (MDH)1 and RNA binding motif protein (RBM)5, were identified.
PQQ-dependent methanol dehydrogenases: rare-earth elements make a difference.
Review
Op den Camp et al., Nijmegen, Netherlands. In Appl Microbiol Biotechnol, 2013
Genomic analyses indicated the existence of another MDH distantly related to the MxaFI-MDHs.
Prerequisites for amplicon pyrosequencing of microbial methanol utilizers in the environment.
Review
Stacheter et al., Bayreuth, Germany. In Front Microbiol, 2012
To enable a comprehensive assessment of methanol utilizers in the environment, new primers targeting genes of the PQQ MDH in Methylibium (mdh2), of the nicotinamide adenine dinucleotide-dependent MDH (mdh), of the methanol oxidoreductase of Actinobacteria (mdo), of the fungal flavin adenine nucleotide-dependent alcohol oxidase (mod1, mod2, and homologs), and of the gene of the large subunit of the methanol:corrinoid methyltransferases (mtaC) in methanogens and acetogens need to be developed.
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
GeneRIF
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Nonclassical regulation of transcription: interchromosomal interactions at the malic enzyme locus of Drosophila melanogaster.
GeneRIF
Merritt et al., Greater Sudbury, Canada. In Genetics, 2011
trans-interaction between alleles of the Malic enzyme (Men) locus in Drosophila melanogaster
Alcohol sensitivity in Drosophila: translational potential of systems genetics.
GeneRIF
Anholt et al., Raleigh, United States. In Genetics, 2009
Studies suggest that variation in levels of cytoplasmic malic enzyme may contribute to variation in alcohol consumption.
A nucleocytoplasmic malate dehydrogenase regulates p53 transcriptional activity in response to metabolic stress.
GeneRIF
Youn et al., Seoul, South Korea. In Cell Death Differ, 2009
Malate Dehydrogenase directly regulates the Tumor Suppressor Protein p53-dependent apoptosis upon glucose deprivation and involved in maintaining cellular metabolic state and further determining cell death.
Hormone-dependent and hormone-independent control of metabolic and developmental functions of malate dehydrogenase - review.
Review
Farkas et al., Bratislava, Slovakia. In Endocr Regul, 2009
Malate dehydrogenases (MDHs) are specific class of ubiquitous and multimeric oxidative decarboxylases with well conserved amino acid sequences in structurally important regions and with similar overall structural topology.
Ultra high throughput sequencing excludes MDH1 as candidate gene for RP28-linked retinitis pigmentosa.
GeneRIF
Rivolta et al., Lausanne, Switzerland. In Mol Vis, 2008
The MDH1 gene is not the cause of RP28-linked autosomal recessive retinitis pigmentosa.
A new family of NAD(P)H-dependent oxidoreductases distinct from conventional Rossmann-fold proteins.
Review
Esaki et al., Uji, Japan. In J Biosci Bioeng, 2005
Numerous putative proteins belonging to the family have been annotated as malate dehydrogenase (MDH) or lactate dehydrogenase (LDH) according to the previous classification as type-2 malate/L-lactate dehydrogenases.
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