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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

A disintegrin and metallopeptidase domain 11

mDC, ADAM11, metalloproteinase-like, disintegrin-like, cysteine-rich
chemoattractant for dendritic cells, natural killer (NK) cells, and the Th2 subset of peripheral blood T cells [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, CD86, IL-10, CD4, CD80
Papers on mDC
Cutting Edge: MicroRNA-223 Regulates Myeloid Dendritic Cell-Driven Th17 Responses in Experimental Autoimmune Encephalomyelitis.
New
Miller et al., Chicago, United States. In J Immunol, Feb 2016
Thus, miR-223 controls mDC-induced activation of pathologic Th17 responses during autoimmune inflammation.
Tolerogenic dendritic cells show gene expression profiles that are different from those of immunogenic dendritic cells in DBA/1 mice.
New
Lim et al., South Korea. In Autoimmunity, Jan 2016
Scin (tDC-specific genes) and Orm1, Pdlim4 and Enpp2 (mDC-specific genes) were validated by real-time qRT-PCR.
Interleukin 25 Receptor Expression on Airway Dendritic Cells After Allergen Challenge in Asthmatic Subjects.
New
O'Byrne et al., Hamilton, Canada. In Am J Respir Crit Care Med, Jan 2016
RESULTS: Inhaled allergen significantly increased both mDC and pDC numbers in sputum, but not in blood.
[Immunomodulation of Uncaria tomentosa over dendritic cells, il-12 and profile TH1/TH2/TH17 in breast cancer].
New
Aguilar et al., Lima, Peru. In Rev Peru Med Exp Salud Publica, Dec 2015
However, H exhibited a decrease in the percentage of mDC (myeloid DC) and an increase in HLA-DR and CD86 expression at 1000 μg/mL.
TSLP production by dendritic cells is modulated by IL-1β and components of the endoplasmic reticulum stress response.
New
Goodall et al., Cambridge, United Kingdom. In Eur J Immunol, Dec 2015
We show that human monocyte-derived DC (mDC) secretion of TSLP in response to C. albicans and β-glucans requires dectin-1, Syk, NF-κB and p38 MAPK signalling.
Gene expression analysis during acute hepatitis C virus infection associates dendritic cell activation with viral clearance.
New
Sarobe et al., Pamplona, Spain. In J Med Virol, Nov 2015
By using microarrays, gene expression was compared in resting and activated peripheral blood plasmacytoid (pDC) and myeloid (mDC) DC from acute HCV resolving patients (AR) and from patients who become chronically infected (ANR), as well as in healthy individuals (CTRL) and chronically-infected patients (CHR).
Interferon-α induces marked alterations in circulating regulatory T cells, NK cell subsets and dendritic cells in patients with JAK2(V617F) -positive essential thrombocythemia and polycythemia vera.
New
Svane et al., Copenhagen, Denmark. In Eur J Haematol, Oct 2015
Furthermore, PD-L1 expression was reduced on mDC (P=0.003) and increased on pDCs (P=0.02).
Up-regulated S100 calcium binding protein A8 in Plasmodium-infected patients correlates with CD4(+)CD25(+)Foxp3 regulatory T cell generation.
Sohn et al., Gainesville, United States. In Malar J, 2014
Full amino acids of S100A8 were synthesized to verify the functions for maturation of immature dendritic cell (iDC) and evaluation of CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) generation by mature DC (mDC).
PDL1 Expression on Plasma and Dendritic Cells in Myeloma Bone Marrow Suggests Benefit of Targeted anti PD1-PDL1 Therapy.
Sundan et al., Trondheim, Norway. In Plos One, 2014
A correlation between the proportion of PDL1+ PC and CD141+ mDC was found, suggesting both cell types could down-regulate the anti-tumor T cell response.
Blood dendritic cells: "canary in the coal mine" to predict chronic inflammatory disease?
Review
Cutler et al., Augusta, United States. In Front Microbiol, 2013
Thus it would seem prudent when assessing chronic inflammatory disease risk to consider blood mDC numbers, and the microbial content (microbiome) and activation state of these mDCs.
Dendritic cell dysregulation during HIV-1 infection.
Review
Bhardwaj et al., New York City, United States. In Immunol Rev, 2013
Dependent upon the stage of HIV-1 infection, mDC function is altered in response to Toll-like receptor ligands, which further hinders adaptive immunity and limits feasibility of therapeutic vaccine strategies.
ADAM22 as a prognostic and therapeutic drug target in the treatment of endocrine-resistant breast cancer.
Review
Young et al., Dublin, Ireland. In Vitam Horm, 2012
In addition to being a ligand for ADAM11, ADAM22, and ADAM23, LGI1 may play a role as a tumor suppressor.
Understanding dendritic cells and their role in cutaneous carcinoma and cancer immunotherapy.
Review
Carucci et al., New York City, United States. In Clin Dev Immunol, 2012
Multiple distinct subsets of DCs have been identified in the skin, where they can be broadly subcategorized into epidermal Langerhans cells (LC), myeloid-derived dermal dendritic cells (mDC) and plasmacytoid dendritic cells (pDC).
[Immunobiological response against RNA virus infection].
Review
Matsumoto et al., Japan. In Uirusu, 2012
This process unequivocally involves the maturation of antigen-presenting dendritic cell (mDC), and virus products frequently block this step.
A role for interleukin-2 trans-presentation in dendritic cell-mediated T cell activation in humans, as revealed by daclizumab therapy.
Impact
Bielekova et al., Bethesda, United States. In Nat Med, 2011
We show that mDCs (and antigen-experienced T cells) secrete IL-2 toward the mDC-T cell interface in an antigen-specific manner, and mDCs 'lend' their CD25 to primed T cells in trans to facilitate early high-affinity IL-2 signaling, which is crucial for subsequent T cell expansion and development of antigen-specific effectors.
Altered nociceptive response in ADAM11-deficient mice.
GeneRIF
Kuromitsu et al., Tsukuba, Japan. In Brain Res, 2006
ADAM11 may play a role in pain transmission and in inflammatory regulation mechanisms underlying changes in the threshold for pain perception.
Deficits in spatial learning and motor coordination in ADAM11-deficient mice.
GeneRIF
Kuromitsu et al., Tsukuba, Japan. In Bmc Neurosci, 2005
ADAM11 may have a role in learning and motor coordination.
Elevated expression of TARC (CCL17) and MDC (CCL22) in models of cigarette smoke-induced pulmonary inflammation.
GeneRIF
Seither et al., Biberach an der Riß, Germany. In Biochem Biophys Res Commun, 2005
Our data indicate that instead of Th2 cells, airway epithelial cells expressing CCR4 might be the principal targets for MDC and TARC released from alveolar macrophages during cigarette smoke-induced airway inflammation.
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