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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interferon induced with helicase C domain 1

MDA5, IFIH1
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon (IFNB) and a protein kinase C-activating compound, mezerein (MEZ). Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: RIG-I, ACID, TLR3, CAN, VISA
Papers on MDA5
Regulation of antiviral innate immune signaling by stress-induced RNA granules.
New
Onomoto et al., Chiba, Japan. In J Biochem, Feb 2016
Among the three known RLRs, RIG-I, and melanoma differentiation-associated gene 5 (MDA5) recognize distinct non-self signatures of viral RNA and activate antiviral signaling.
Activation of RNase L by murine coronavirus in myeloid cells is dependent on basal Oas gene expression and independent of virus-induced interferon.
New
Weiss et al., Philadelphia, United States. In J Virol, Feb 2016
Infection with ns2(H126R) activated RNase L in Ifih1(-/-) BMM to a similar extent as in WT BMM despite the lack of IFN induction in the absence of MDA5 expression.
Correction: Human β-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid.
New
Dorin et al., In Plos Genet, Jan 2016
UNASSIGNED: [This corrects the article DOI: 10.1371/journal.pgen.1005673.].
The immune evasion function of J and Beilong virus V proteins is distinct from that of other paramyxoviruses, consistent with a separate "Jeilongvirus" genus.
New
Moseley et al., Australia. In J Gen Virol, Jan 2016
Nevertheless, the V proteins of both viruses interacted with melanoma differentiation associated protein 5 (MDA5) and robustly inhibited MDA5-dependent activation of the IFN-β promoter.
ADAR1, inosine and the immune sensing system: distinguishing self from non-self.
Review
New
Walkley et al., Australia. In Wiley Interdiscip Rev Rna, Jan 2016
Further analysis of this observation has lead to the conclusion that editing by ADAR1 is required to prevent activation of the cytosolic innate immune system, primarily focused on the dsRNA sensor MDA5 and leading to downstream signaling via MAVS.
RIG-I-like receptors and autoimmune diseases.
Review
New
Fujita et al., Kyoto, Japan. In Curr Opin Immunol, Dec 2015
We herein summarize recent reports on RLR mutations in patients and MDA5 mutant mice, and discuss possible mechanisms by which aberrant activation of RLRs can cause autoimmunity.
Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development.
New
Impact
Stetson et al., Seattle, United States. In Immunity, Dec 2015
Here, we demonstrate that ADAR1 is a specific and essential negative regulator of the MDA5-MAVS RNA sensing pathway.
Helicases in Antiviral Immunity: Dual Properties as Sensors and Effectors.
Review
New
Hur et al., Boston, United States. In Trends Biochem Sci, Oct 2015
In this review, we discuss a few examples, including retinoic acid-inducible gene-I (RIG-I), melanoma differentiation-associated gene 5 (MDA5), and Dicer, focusing on their dual functions as both sensors and effectors.
RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself.
New
Impact
Walkley et al., Australia. In Science, Oct 2015
Finally, embryonic death and phenotypes of Adar1(E861A/E861A) were rescued by concurrent deletion of the cytosolic sensor of dsRNA, MDA5.
DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts.
New
Impact
De Carvalho et al., Toronto, Canada. In Cell, Sep 2015
This is associated with induction of dsRNAs derived at least in part from endogenous retroviral elements, activation of the MDA5/MAVS RNA recognition pathway, and downstream activation of IRF7.
[Progress of Autoantibody Examinations for Connective Tissue Diseases].
Review
New
Morinobu et al., In Rinsho Byori, May 2015
Anti-MDA5 antibody is detected in patients with clinically amyopathic DM, often complicated by rapidly progressive interstitial lung disease.
MDA5-positive dermatomyositis: an uncommon entity in Europe with variable clinical presentations.
Review
Scaletti et al., Florence, Italy. In Clin Mol Allergy, 2014
Autoantibodies directed against the cytosolic pathogen sensor MDA5 (CADM 140) can mark this subtype of dermatomyositis which has been reported to associate, in particular ethnic groups, with severe progressive interstitial lung disease, poor prognosis and an hyperferritinemic status resembling hemophagocytic-like syndromes.
Meta-analysis of STAT4 and IFIH1 polymorphisms in type 1 diabetes mellitus patients with autoimmune polyglandular syndrome type III.
Brandão et al., Recife, Brazil. In Genet Mol Res, 2014
Signal transducer and activator of transcription 4 (STAT4) is a well-known regulator of proinflammatory cytokines, and interferon-induced with helicase C domain 1 (IFIH1) is activated in the interferon type I response.
Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates.
Impact
Reis e Sousa et al., London, United Kingdom. In Nature, 2014
In the cytosol, the RIG-I-like receptors (RLRs), RIG-I (retinoic acid-inducible gene I; encoded by DDX58) and MDA5 (melanoma differentiation-associated gene 5; encoded by IFIH1) sense atypical RNAs associated with virus infection.
Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling.
Impact
Crow et al., Manchester, United Kingdom. In Nat Genet, 2014
We found that heterozygous mutations in the cytosolic double-stranded RNA receptor gene IFIH1 (also called MDA5) cause a spectrum of neuroimmunological features consistently associated with an enhanced interferon state.
Human respiratory syncytial virus nucleoprotein and inclusion bodies antagonize the innate immune response mediated by MDA5 and MAVS.
GeneRIF
Santangelo et al., Atlanta, United States. In J Virol, 2012
Human respiratory syncytial virus nucleoprotein and inclusion bodies antagonize the innate immune response mediated by MDA5 and MAVS.
A novel dermato-pulmonary syndrome associated with MDA-5 antibodies: report of 2 cases and review of the literature.
Review
GeneRIF
Rosen et al., Baltimore, United States. In Medicine (baltimore), 2012
We present 2 cases of MDA-5-associated dermato-pulmonary syndrome and provide a comprehensive review of available literature. [review]
Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response.
Impact
GeneRIF
Chen et al., Dallas, United States. In Immunity, 2012
The CARD domains of MDA5 bind to K63 polyubiquitin & this binding is essential for MDA5 to activate the transcription factor IRF3.
MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA.
GeneRIF
Modis et al., New Haven, United States. In Embo J, 2012
It was shown that MDA5 cooperatively binds short RNA ligands as a dimer with a 16-18-basepair footprint. A crystal structure of the MDA5 helicase-insert domain demonstrates an evolutionary relationship with the archaeal Hef helicases.
Triggering of the dsRNA sensors TLR3, MDA5, and RIG-I induces CD55 expression in synovial fibroblasts.
GeneRIF
Hamann et al., Amsterdam, Netherlands. In Plos One, 2011
Triggering of the dsRNA sensors TLR3, MDA5, and RIG-I induces CD55 expression in synovial fibroblasts.
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