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F-box and WD-40 domain protein 2

MD6, FBXW2, FBW2, Fwd2, F-box and WD repeat domain containing 2
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MyoD, SCF, Ubiquitin, Cullin, lacZ
Papers on MD6
Reorganization of visual processing in age-related macular degeneration depends on foveal loss.
Kanwisher et al., Cambridge, United States. In Optom Vis Sci, 2014
Here, we conduct a stronger test of the dependence of reorganization of visual processing in MD on complete loss of foveal function, by bringing back one (called MD6) of the two participants who previously did not show reorganization and who showed foveal sparing.
A high-throughput open-array qPCR gene panel to identify housekeeping genes suitable for myometrium and leiomyoma expression analysis.
Hernández et al., Santa Cruz de Tenerife, Spain. In Gynecol Oncol, 2014
We identified 10 housekeeping genes, ARF1, MRPL19, FBXW2, PUM1, UBE2D2, EIF2B1, HPRT1, GUSB, ALAS1, and TRIM27, as the best set of normalization genes for comparing relative expression between leiomyoma and myometrium samples in proliferative and secretory phases.
Identification and validation of quantitative PCR reference genes suitable for normalizing expression in normal and dystrophic cell culture models of myogenesis.
Wells et al., London, United Kingdom. In Plos Curr, 2013
We measured expression of 11 candidate normalization genes (Cdc40, Htatsf1, Ap3d1, Csnk2a2, Fbxw2, Fbxo38, Pak1ip1, Zfp91, GAPDH, ActB, 18S) in three cell culture models of myogenesis (C2C12 , H2K2B4, and the dystrophic line H2KSF1).
RACK1 (receptor for activated C-kinase 1) interacts with FBW2 (F-box and WD-repeat domain-containing 2) to up-regulate GCM1 (glial cell missing 1) stability and placental cell migration and invasion.
Chen et al., Taipei, Taiwan. In Biochem J, 2013
The F-box protein, FBW2 (F-box and WD-repeat domain-containing 2), which contains five WD (tryptophan-aspartate) repeats, recognizes GCM1 and mediates its ubiquitination via the SCFFBW2 E3 ligase complex.
Antibacterial activity and QSAR of chalcones against biofilm-producing bacteria isolated from marine waters.
Doble et al., Chennai, India. In Sar Qsar Environ Res, 2010
In this study, three marine organisms, namely Bacillus flexus (LD1), Pseudomonas fluorescens (MD3) and Vibrio natriegens (MD6), were isolated from biofilms formed on polymer and metal surfaces immersed in ocean water.
An endogenous F-box protein regulates ARGONAUTE1 in Arabidopsis thaliana.
Poethig et al., Philadelphia, United States. In Silence, 2009
A screen for mutations that suppress the sqn phenotype produced loss-of-function mutations in the F-box gene FBW2.
Mechanism of hypoxia-induced GCM1 degradation: implications for the pathogenesis of preeclampsia.
Chen et al., Taipei, Taiwan. In J Biol Chem, 2009
Activated GSK-3beta phosphorylates GCM1 on Ser322, which in turn recruits the F-box protein FBW2, leading to GCM1 ubiquitination and degradation.
Identification of novel reference genes using multiplatform expression data and their validation for quantitative gene expression analysis.
Shin et al., Seoul, South Korea. In Plos One, 2008
Here, we first selected candidate housekeeping genes (HKGs) using human gene expression data from different platforms including EST, SAGE, and microarray, and 13 novel ERGs (nERGs) (ARL8B, CTBP1, CUL1, DIMT1L, FBXW2, GPBP1, LUC7L2, OAZ1, PAPOLA, SPG21, TRIM27, UBQLN1, ZNF207) were further identified from these HKGs.
Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation.
GeneRIF
Chen et al., Taipei, Taiwan. In Biol Reprod, 2008
UBE2D2 is required for GCMa ubiquitination and for association with the SCF(FBXW2) complex.
A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2.
Begovich et al., Alameda, United States. In Plos Genet, 2008
spanned a large 525 kb region from FBXW2 to GSN.
MyoD- and nerve-dependent maintenance of MyoD expression in mature muscle fibres acts through the DRR/PRR element.
Hughes et al., London, United Kingdom. In Bmc Dev Biol, 2007
Here we employ the MD6.0-lacZ transgenic mouse, in which the 6 kb proximal enhancer/promoter (DRR/PRR) of MyoD drives lacZ, to show that MyoD is present and transcriptionally active in many adult muscle fibres.
FBW2 targets GCMa to the ubiquitin-proteasome degradation system.
GeneRIF
Chen et al., Taipei, Taiwan. In J Biol Chem, 2005
the SCF(hFBW2) E3 complex has a key role in targeting hGCMa to the ubiquitin-proteasome degradation system
MyoD-lacZ transgenes are early markers in the neural retina, but MyoD function appears to be inhibited in the developing retinal cells.
Kablar, Halifax, Canada. In Int J Dev Neurosci, 2004
The analysis of MD6.0-lacZ and 258/-2.5lacZ
Two-dimensional rotating-frame Overhauser spectroscopy (ROESY) and (13)C NMR study of the interactions between maltodextrin and an anionic surfactant.
Charles Dickinson et al., Amherst Center, United States. In Carbohydr Res, 2004
The SDS-H3 CH(2) protons were resolved from the bulk of the SDS protons, with peaks and shoulders at 1.25 ppm, which indicated an especially strong interaction of the SDS hydrophobic tail with MD6 and some less intense interactions with MD2, 4, and 5.
Different regulatory elements within the MyoD promoter control its expression in the brain and inhibit its functional consequences in neurogenesis.
Kablar, Halifax, Canada. In Tissue Cell, 2002
The MD6.0-lacZ transgene was localized in the basal plate of pons, medulla oblongata (i.e. the medial longitudinal fasciculus) and spinal cord of wild-type and mutant mouse embryos at various stages of development, whereas the 258/-2.5lacZ
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