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Lymphocyte antigen 96

MD-2, Lymphocyte Antigen 96
This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010] (from NCBI)
Papers using MD-2 antibodies
Tobacco smoke suppresses T cells but not antigen-presenting cells in the lung-associated lymph nodes.
Neyrolles Olivier, In PLoS ONE, 1989
... Functional Grade Purified anti-mouse Toll-like receptor 4 (TLR4)/MD-2 (Clone: MTS510 0) and isotype control (Rat IgG2a, κ) were purchased from ebioscience (San Diego, CA, USA) ...
Papers on MD-2
Glycyrrhizin and isoliquiritigenin suppress the LPS sensor toll-like receptor 4/MD-2 complex signaling in a different manner.
Takatsu et al., Toyama, Japan. In J Leukoc Biol, 2012
GL and ILG modulate the TLR4/MD-2 complex at the receptor level, leading to suppress LPS-induced activation of signaling cascades and cytokine production
NMR studies of hexaacylated endotoxin bound to wild-type and F126A mutant MD-2 and MD-2·TLR4 ectodomain complexes.
Gioannini et al., Iowa City, United States. In J Biol Chem, 2012
In LOS.MD-2 complexes, one of the six fatty acyl chains of LOS is more susceptible to paramagnetic attenuation, suggesting protrusion of that fatty acyl chain from the hydrophobic pocket of MD-2, independent of association with TLR4.
Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2.
Shimizu et al., Tokyo, Japan. In Proc Natl Acad Sci U S A, 2012
Data provide structural evidence of the agonistic property of lipid IVa on TLR4/MD-2 and deepen understanding of the ligand binding and dimerization mechanism by the structurally diverse Lipopolysaccharide (LPS) variants.
Morphine activates neuroinflammation in a manner parallel to endotoxin.
Yin et al., Boulder, United States. In Proc Natl Acad Sci U S A, 2012
Data show that morphine binds to an accessory protein of Toll-like receptor 4 (TLR4), myeloid differentiation protein 2 (MD-2), thereby inducing TLR4 oligomerization and triggering proinflammation.
Respiratory syncytial virus fusion protein-induced toll-like receptor 4 (TLR4) signaling is inhibited by the TLR4 antagonists Rhodobacter sphaeroides lipopolysaccharide and eritoran (E5564) and requires direct interaction with MD-2.
Blanco et al., Baltimore, United States. In Mbio, 2011
Respiratory syncytial virus F protein requires MD-2 for the induction of the TLR4-mediated inflammatory response.
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