Saturated fatty acids trigger TLR4-mediated inflammatory response.
Viçosa, Brazil. In Atherosclerosis, Jan 2016
Thus, our present review provides a new perspective on the potential mechanism by which SFAs could modulate TLR4-induced inflammatory responses: (1) SFAs can be recognized by CD14-TLR4-MD2 complex and trigger inflammatory pathways, similar to lipopolysaccharide (LPS).
Drug Targeting Based on a New Concept-Targeting Against TLR4 as an Example.
Tokyo, Japan. In Endocr Metab Immune Disord Drug Targets, 2014
In this manuscript, in order to make a novel molecular design to disrupt an interaction between TLR4/MD-2 and endogenous ligands, we provide a potential binding style of the TLR4/MD-2 complex with HMGB1 by using their 3D structural data and docking simulations, and also discuss S100A8 binding to TLR4/MD-2.