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Solute carrier family 16, member 8

MCT3, REMP, Slc16A8, monocarboxylate transporter 3
SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010] (from NCBI)
Top mentioned proteins: MCT1, MCT2, ACID, CAN, CD147
Papers on MCT3
Berberine protects against light-induced photoreceptor degeneration in the mouse retina.
New
Dunaief et al., United States. In Exp Eye Res, Nov 2015
Consistent with OCT results, the mRNA levels of Rho in the NSR, and Rpe65 and Mct3 in the RPE, were significantly higher in mice treated with BBR.
Intestinal absorption mechanisms of MTBH, a novel hesperetin derivative, in Caco-2 cells, and potential involvement of monocarboxylate transporter 1 and multidrug resistance protein 2.
New
Li et al., Hefei, China. In Eur J Pharm Sci, Nov 2015
We verified MCT1, MCT3, MCT4, MCT5, and MCT6 were expressed in Caco-2 cells by western blot.
Influence of GTP on system specific chaperone - Twin arginine signal peptide interaction.
New
Turner et al., Calgary, Canada. In Biochem Biophys Res Commun, Nov 2015
Many Tat substrates have a system specific chaperone - redox enzyme maturation protein (REMP) - for final folding and assembly prior to Tat binding.
The monocarboxylate transporters exist in the cattle endocrine pancreas.
New
Kato et al., Az Zaqāzīq, Egypt. In Histochem Cell Biol, Feb 2015
RT-PCR verified the existence of mRNA transcripts for eight MCT isoforms, namely, MCT1, MCT2, MCT3, MCT4, MCT5, MCT8, MCT13, and MCT14 in cattle pancreas.
'Come into the fold': A comparative analysis of bacterial redox enzyme maturation protein members of the NarJ subfamily.
Review
Turner et al., Calgary, Canada. In Biochim Biophys Acta, 2014
Here we critically dissect current knowledge pertaining to REMPs of the nitrate reductase delta superfamily, specifically recognized in Escherichia coli to include NarJ, NarW, TorD, DmsD, and YcdY, also referred to as the NarJ REMP subfamily.
Monocarboxylate transporters 1-4 in NSCLC: MCT1 is an independent prognostic marker for survival.
Bremnes et al., Tromsø, Norway. In Plos One, 2013
RESULTS: In univariate analyses; ↓ MCT1 (P = 0.021) and ↑ MCT4 (P = 0.027) expression in cancer cells, and ↑ MCT1 (P = 0.003), ↓ MCT2 (P = 0.006), ↓ MCT3 (P = 0.020) expression in stromal cells correlated significantly with a poor DSS.
Entinostat is a histone deacetylase inhibitor selective for class 1 histone deacetylases and activates HIV production from latently infected primary T cells.
Lewin et al., Melbourne, Australia. In Aids, 2013
METHODS: Latently infected chemokine ligand 19 (CCL19)-treated CD4⁺ T cells and the latently infected cell lines ACH2 and J-Lat were treated with a panel of HDACi, including entinostat, vorinostat, panonbinostat and MCT3.
Expression and cellular localization of monocarboxylate transporters (MCT2, MCT7, and MCT8) along the cattle gastrointestinal tract.
Kato et al., Ebetsu, Japan. In Cell Tissue Res, 2013
Reverse transcription with the polymerase chain reaction was used to study the regional distribution of MCT2, MCT3, and MCT5-MCT14 in the cattle gastrointestinal tract and verified the existence of MCT mRNA transcripts for MCT2, MCT3, MCT4, MCT7, MCT8, MCT9, MCT10, MCT13, and MCT14 in the ruminal and abomasal epithelia, mRNA transcripts for MCT2, MCT3, MCT4, MCT7, MCT8, MCT10, MCT13, and MCT14 in the jejunum, and mRNA transcripts for MCT2, MCT3, MCT4, MCT7, MCT8, MCT13, and MCT14 in the caecum of cattle.
The SLC16 gene family - structure, role and regulation in health and disease.
Review
Halestrap, Bristol, United Kingdom. In Mol Aspects Med, 2013
Four (SLC16A1, SLC16A3, SLC16A7, and SLC16A8) encode monocarboxylate transporters (MCT1, MCT4, MCT2, and MCT3, respectively) catalysing the proton-linked transport of monocarboxylates such as l-lactate, pyruvate and ketone bodies across the plasma membrane.
Knockdown of autophagy-related protein 5, ATG5, decreases oxidative stress and has an opposing effect on camptothecin-induced cytotoxicity in osteosarcoma cells.
Kleinerman et al., Houston, United States. In Bmc Cancer, 2012
K7M3 cells exhibited higher basal autophagy levels than DLM8 cells and non-transformed murine MCT3 osteoblasts.
Intestinal transporters for endogenic and pharmaceutical organic anions: the challenges of deriving in-vitro kinetic parameters for the prediction of clinically relevant drug-drug interactions.
Review
Steffansen et al., Copenhagen, Denmark. In J Pharm Pharmacol, 2012
KEY FINDINGS: Current knowledge on the intestinal expression of the apical sodium-dependent bile acid transporter (ASBT), the breast cancer resistance protein (BCRP), the monocarboxylate transporters (MCT) 1, MCT3-5, the multidrug resistance associated proteins (MRP) 1-6, the organic anion transporting polypetides (OATP) 2B1, 1A2, 3A1 and 4A1, and the organic solute transporter α/β (OSTα/β) has been covered along with an overview of their substrates and inhibitors.
Effect of Medium-chain Triglyceride (MCT) on Growth Performance, Nutrient Digestibility, Blood Characteristics in Weanling Pigs.
Kim et al., Taejŏn, South Korea. In Asian-australas J Anim Sci, 2012
In both of Exp. 1 and Exp. 2, the same dietary treatments were utilized as follows : i) negative control (NC), ii) positive control (PC), NC+antibiotics (40 mg/kg Tiamulin, 110 mg/kg Tylosin, and 10 mg/kg Enramycin, iii) MCT3, NC+0.32% (phase 1, 2 and 3) MCT, and iv) MCT5, NC+0.55% (phase 1), 0.32% (phase 2 and 3) MCT.
The monocarboxylate transporter family--Structure and functional characterization.
Review
Halestrap, Bristol, United Kingdom. In Iubmb Life, 2012
MCT1, MCT3, and MCT4 bind preferentially to basigin and MCT2 to embigin.
The hydrophobic core of twin-arginine signal sequences orchestrates specific binding to Tat-pathway related chaperones.
Bollen et al., Amsterdam, Netherlands. In Plos One, 2011
REMP binding protects signal peptides against degradation by proteases.
Morphological and chemical mechanisms of elongated mineral particle toxicities.
Review
Dodson et al., United States. In J Toxicol Environ Health B Crit Rev, 2010
Much of our understanding regarding the mechanisms for induction of disease following inhalation of respirable elongated mineral particles (REMP) is based on studies involving the biological effects of asbestos fibers.
Altered visual function in monocarboxylate transporter 3 (Slc16a8) knockout mice.
GeneRIF
Philp et al., Philadelphia, United States. In Am J Physiol Cell Physiol, 2008
Disruption of Mct3 leads to a potentially reversible decrease in subretinal space pH, thereby reducing the magnitude of the light suppressible photoreceptor current.
Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8.
GeneRIF
Heuer et al., Jena, Germany. In J Clin Invest, 2007
MCT8-null mice developed without overt deficits but also exhibited distorted 3,5,3'-triiodothyronine (T3) and thyroxine (T4) serum levels, resulting in increased hepatic activity of type 1 deiodinase (D1).
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