The SLC16 gene family - structure, role and regulation in health and disease.
Bristol, United Kingdom. In Mol Aspects Med, 2013
Four (SLC16A1, SLC16A3, SLC16A7, and SLC16A8) encode monocarboxylate transporters (MCT1, MCT4, MCT2, and MCT3, respectively) catalysing the proton-linked transport of monocarboxylates such as l-lactate, pyruvate and ketone bodies across the plasma membrane.
Basigin interacts with both MCT1 and MCT2 in murine spermatozoa.
Homburg, Germany. In J Cell Physiol, 2012
Data suggest that basigin interacts with MCT1 and MCT2 to locate them properly in the membrane of spermatogenic cells and that this may enable sperm to utilize lactate as an energy substrate contributing to cell survival.