Monocarboxylate transporters: new players in body weight regulation.
Lausanne, Switzerland. In Obes Rev, Feb 2015
Recently, a knockin mouse for a member of the monocarboxylate transporter (MCT) family, MCT1, was demonstrated to exhibit a typical phenotype of resistance to diet-induced obesity and a protection from its associated metabolic perturbations.
Could the eIF2α-Independent Translation Be the Achilles Heel of Cancer?
Ottawa, Canada. In Front Oncol, 2014
This mechanism, which appears to be shared by some RNA viruses and Internal Ribosome Entry Site-containing cellular mRNAs and utilizes auxiliary proteins, such as eIF5B, eIF2D, and MCT-1, is responsible for the selective translation of cancer-associated genes and could represent a weak point amenable to specific targeting for the treatment of cancer.
Translation. DENR-MCT1 reinitiates translation.
In Nat Rev Mol Cell Biol, 2014
Translation reinitiation of open reading frames (ORFs) located after upstream ORFs is dependent on the DENR–MCT1 complex, which regulates a specific set of mRNAs.
Oligodendroglia metabolically support axons and contribute to neurodegeneration.
Baltimore, United States. In Nature, 2012
monocarboxylate transporter 1 (MCT1), is highly enriched within oligodendroglia and disruption of this transporter produces axon damage and neuron loss in animal and cell culture models; in addition, this same transporter is reduced in patients with, and in mouse models of, amyotrophic lateral sclerosis, suggesting a role for oligodendroglial MCT1 in pathogenesis