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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Solute carrier family 16, member 1

MCT1, monocarboxylate transporter 1
The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: ACID, MCT2, V1a, CAN, CD147
Papers using MCT1 antibodies
Papers on MCT1
Monocarboxylate Transporters MCT1 and MCT4 Regulate Migration and Invasion of Pancreatic Ductal Adenocarcinoma Cells.
New
Pedersen et al., Copenhagen, Denmark. In Pancreas, Feb 2016
Lactate influx capacity was highest in AsPC-1 cells and lowest in HPDE cells and was inhibited by the MCT inhibitor α-cyano-4-hydroxycinnamate (4-CIN), MCT1/MCT2 inhibitor AR-C155858, or knockdown of MCT1 or MCT4.
Histological and immunohistochemical evaluation of stroma variations and their correlation with the Ki-67 index and expressions of glucose transporter 1 and monocarboxylate transporter 1 in canine thyroid C-cell carcinomas.
New
Taniyama et al., In J Vet Med Sci, Feb 2016
Moreover, we examined whether the variations correlated with the Ki-67 index and expressions of glucose transporter 1 (GLUT-1) and monocarboxylate transporter 1 (MCT-1).
Cell-specific modulation of monocarboxylate transporter expression contributes to the metabolic reprogramming taking place following cerebral ischemia.
New
Pellerin et al., Lausanne, Switzerland. In Neuroscience, Feb 2016
After 1 hour of reperfusion, an upregulation of the three MCTs was observed in the striatum (MCT1 ipsilateral 2.73 ± 0.2 and contralateral 2.01 ± 0.4; MCT2 ipsilateral 2.1 ± 0.1; MCT4 ipsilateral 1.65 ± 0.1) and in the surrounding cortex of both the ipsilateral (MCT1 2.4 ± 0.4; MCT2 1.62 ± 0.2; MCT4 1.31 ± 0.1) and contralateral (MCT1 2.78 ± 0.4; MCT2 1.76 ± 0.2) hemispheres, compared to the corresponding sham hemispheres.
Expression of Monocarboxylate Transporter Isoforms in Rat Skeletal Muscle Under Hypoxic Preconditioning and Endurance Training.
New
Bansal et al., Delhi, India. In High Alt Med Biol, Jan 2016
Expression of monocarboxylate transporter isoforms in rat skeletal muscle under hypoxic preconditioning and endurance training.
Delivery of siRNA targeting tumor metabolism using non-covalent PEGylated chitosan nanoparticles: Identification of an optimal combination of ligand structure, linker and grafting method.
New
Feron et al., Brussels, Belgium. In J Control Release, Jan 2016
Here, we showed that non-covalent PEGylation of chitosan-based nanoparticles loaded with siRNA targeting two key transporters of energy fuels for cancer cells, namely the lactate transporter MCT1 and the glutamine transporter ASCT2, could lead to significant antitumor effects.
Monocarboxylate transporters: new players in body weight regulation.
Review
New
Pellerin et al., Lausanne, Switzerland. In Obes Rev, Feb 2015
Recently, a knockin mouse for a member of the monocarboxylate transporter (MCT) family, MCT1, was demonstrated to exhibit a typical phenotype of resistance to diet-induced obesity and a protection from its associated metabolic perturbations.
Lactate transport and signaling in the brain: potential therapeutic targets and roles in body-brain interaction.
Review
New
Bergersen, Oslo, Norway. In J Cereb Blood Flow Metab, Feb 2015
The localization and function of HCAR1 and the three MCTs (MCT1, MCT2, and MCT4) expressed in brain constitute the focus of this review.
Could the eIF2α-Independent Translation Be the Achilles Heel of Cancer?
Review
Holcik, Ottawa, Canada. In Front Oncol, 2014
This mechanism, which appears to be shared by some RNA viruses and Internal Ribosome Entry Site-containing cellular mRNAs and utilizes auxiliary proteins, such as eIF5B, eIF2D, and MCT-1, is responsible for the selective translation of cancer-associated genes and could represent a weak point amenable to specific targeting for the treatment of cancer.
Bioavailability of different dietary supplemental methionine sources in animals.
Review
Gilbert et al., Blacksburg, United States. In Front Biosci (elite Ed), 2014
It is absorbed mainly by monocarboxylate transporter 1 (MCT1), coupled with the activity of the Na(+)/H(+) exchanger (NHE3), while DL-Met uptake occurs via multiple carrier-mediated systems.
Prognostic Indications of Elevated MCT4 and CD147 across Cancer Types: A Meta-Analysis.
Review
Curry et al., Philadelphia, United States. In Biomed Res Int, 2014
The transporters MCT1 and MCT4 are regulated via expression of their chaperone, CD147.
Monocarboxylate transporter 1 deficiency and ketone utilization.
Impact
van Haaften et al., Nijmegen, Netherlands. In N Engl J Med, 2014
We performed exome sequencing in a patient with recurrent, severe ketoacidosis and identified a homozygous frameshift mutation in the gene encoding monocarboxylate transporter 1 (SLC16A1, also called MCT1).
DENR-MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth.
Impact
Teleman et al., Heidelberg, Germany. In Nature, 2014
Here we uncover the non-canonical initiation factors density regulated protein (DENR) and multiple copies in T-cell lymphoma-1 (MCT-1; also called MCTS1 in humans) as the first selective regulators of eukaryotic re-initiation.
Translation. DENR-MCT1 reinitiates translation.
Impact
Zlotorynski, In Nat Rev Mol Cell Biol, 2014
Translation reinitiation of open reading frames (ORFs) located after upstream ORFs is dependent on the DENR–MCT1 complex, which regulates a specific set of mRNAs.
MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors.
Impact
Sabatini et al., Cambridge, United States. In Nat Genet, 2013
We identified the SLC16A1 gene product, MCT1, as the main determinant of 3-BrPA sensitivity.
Oligodendroglia metabolically support axons and contribute to neurodegeneration.
Impact
GeneRIF
Rothstein et al., Baltimore, United States. In Nature, 2012
monocarboxylate transporter 1 (MCT1), is highly enriched within oligodendroglia and disruption of this transporter produces axon damage and neuron loss in animal and cell culture models; in addition, this same transporter is reduced in patients with, and in mouse models of, amyotrophic lateral sclerosis, suggesting a role for oligodendroglial MCT1 in pathogenesis
Overexpression of monocarboxylate transporter-1 (SLC16A1) in mouse pancreatic β-cells leads to relative hyperinsulinism during exercise.
GeneRIF
Rutter et al., London, United Kingdom. In Diabetes, 2012
It was shown that forced overexpression of MSlc16a1 in beta-cells replicates the key features of exercise-induced hyperinsulinism and highlights the importance of this transporter's absence from these cells for the normal control of insulin secretion.
Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors.
GeneRIF
Feron et al., Brussels, Belgium. In Cancer Res, 2012
our findings identify MCT1 as a target for p53 repression and they suggest that MCT1 elevation in p53-deficient tumors allows them to adapt to metabolic needs by facilitating lactate export or import depending on the glucose availability.
Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs).
GeneRIF
Baltazar et al., Barretos, Brazil. In J Bioenerg Biomembr, 2012
Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors.
Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.
GeneRIF
Feron et al., Brussels, Belgium. In Plos One, 2011
The lactate transporter monocarboxylate transporter 1 (MCT1) is the main regulator of HIF-1 activation by lactate in endothelial cells.
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