Accurate Prediction and Validation of Response to Endocrine Therapy in Breast Cancer.
London, United Kingdom. In J Clin Oncol, Aug 2015
RESULTS: The molecular response to letrozole was characterized and a four-gene classifier of clinical response was established (accuracy of 96%) on the basis of the level of two genes before treatment (one gene [IL6ST] was associated with immune signaling, and the other [NGFRAP1] was associated with apoptosis) and the level of two proliferation genes (ASPM, MCM4) after 2 weeks of therapy.
Primary Immunodeficiencies Associated with EBV Disease.
Bethesda, United States. In Curr Top Microbiol Immunol, 2014
These include diseases due to mutations in PIK3CD, PIK3R1, CTPS1, STK4, GATA2, MCM4, FCGR3A, CARD11, ATM, and WAS.
ACTH resistance: genes and mechanisms.
London, United Kingdom. In Endocr Dev, 2012
Novel gene defects in FGD have recently been recognised in mini-chromosome maintenance-deficient 4 homologue (MCM4) and nicotinamide nucleotide transhydrogenase (NNT).