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Minichromosome maintenance complex component 7

MCM2, MCM7
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, PCNA, MCM4, Cdc6, MCM5
Papers using MCM2 antibodies
Construction of a self-excisable bacterial artificial chromosome containing the human cytomegalovirus genome and mutagenesis of the diploid TRL/IRL13 gene.
Supplier
Nelson Jay A., In PLoS Pathogens, 2001
... (Virusys), α-IE1/IE2 (a gift from Jay Nelson at Oregon Health and Science University), α-actin, α-GFP, α-MCM2 (all three from Abcam), α-p16 ...
A pRb-independent mechanism preserves the postmitotic state in terminally differentiated skeletal muscle cells
Supplier
Crescenzi Marco et al., In The Journal of Cell Biology, 1996
... (BD Biosciences); p107, clone SD9; p130, C-20; cycD1, M-20; cycA, C-19; cycE, M-20; PCNA, PC10; MCM2, N-19 (Santa Cruz Biotechnology, Inc.); RPA70, 2H10 (NeoMarkers); ...
Papers on MCM2
Correlation between levels of expression of minichromosome maintenance proteins, Ki-67 proliferation antigen and metallothionein I/II in laryngeal squamous cell cancer.
New
Dziegiel et al., Wrocław, Poland. In Int J Oncol, Feb 2016
MCM2, MCM3 and MCM7 are minichromosome maintenance proteins found in dividing cells and they play a role in DNA synthesis.
Chronic DNA Replication Stress Reduces Replicative Lifespan of Cells by TRP53-Dependent, microRNA-Assisted MCM2-7 Downregulation.
New
Schimenti et al., Ithaca, United States. In Plos Genet, Jan 2016
Here, we report that a key driver of RS-induced senescence is active downregulation of the Minichromosome Maintenance 2-7 (MCM2-7) factors that are essential for replication origin licensing and which constitute the replicative helicase core.
Minichromosome maintenance-2 (MCM2) expression differentiates oral squamous cell carcinoma from pre-cancerous lesions.
New
Khalesi et al., Eşfahān, Iran. In Malays J Pathol, Dec 2015
BACKGROUND: Proteins necessary for DNA replication and normal regulation for the cell cycle include minichromosome maintenance-2 (Mcm-2).
Cantharidin modulates the E2F1/MCM7-miR-106b-93/p21-PTEN signaling axis in MCF-7 breast cancer cells.
New
Yan et al., Shanghai, China. In Oncol Lett, Nov 2015
Notably, CTD repressed the expression of miR-106b-93, its host gene MCM7 and its transcription factor E2F1.
The mechanism of DNA replication termination in vertebrates.
New
Impact
Walter et al., Boston, United States. In Nature, Oct 2015
Dissociation of the replicative CMG helicase (comprising CDC45, MCM2-7 and GINS) occurs only after the final ligation step, and is not required for completion of DNA synthesis, strongly suggesting that converging CMGs pass one another and dissociate from double-stranded DNA.
Structure of the eukaryotic MCM complex at 3.8 Å.
New
Impact
Gao et al., Beijing, China. In Nature, Sep 2015
A central step in this replication is the assembly of the heterohexameric minichromosome maintenance (MCM2-7) helicase complex at replication origins during G1 phase as an inactive double hexamer.
Single-Molecule Visualization of MCM2-7 DNA Loading: Seeing Is Believing.
New
Impact
Walter et al., Boston, United States. In Cell, May 2015
The first event in the initiation of eukaryotic DNA replication is the recruitment of the MCM2-7 ATPase, the core of the replicative DNA helicase, to origins.
Immunohistochemistry-based prognostic biomarkers in NSCLC: novel findings on the road to clinical use?
Review
New
Micke et al., Uppsala, Sweden. In Expert Rev Mol Diagn, Apr 2015
Only 26 proteins first described after 2008 (ALDH1A1, ANXA1, BCAR1, CLDN1, EIF4E, EZH2, FOLR1, FOXM1, IL7R, IL12RB2, KIAA1524, CRMP1, LOX, MCM7, MTA1, MTDH, NCOA3, NDRG2, NEDD9, NES, PBK, PPM1D, SIRT1, SLC7A5, SQSTM1 and WNT1) demonstrated a consistent prognostic association in two or more independent patient cohorts, thus qualifying as promising candidates for diagnostic use.
Crystal structure of the eukaryotic origin recognition complex.
New
Impact
Berger et al., Baltimore, United States. In Nature, Apr 2015
Comparative analyses indicate that ORC encircles DNA, using its winged-helix domain face to engage the mini-chromosome maintenance 2-7 (MCM2-7) complex during replicative helicase loading; however, an observed out-of-plane rotation of more than 90° for the Orc1 AAA+ domain disrupts interactions with catalytic amino acids in Orc4, narrowing and sealing off entry into the central channel.
Switch on the engine: how the eukaryotic replicative helicase MCM2-7 becomes activated.
Review
New
Speck et al., London, United Kingdom. In Chromosoma, Mar 2015
The essential mini-chromosome maintenance proteins 2-7 (MCM2-7) represent the core of the eukaryotic replicative helicase that is loaded at DNA replication origins during G1-phase of the cell cycle.
Critical genes in head and neck squamous cell carcinoma revealed by bioinformatic analysis of gene expression data.
Li et al., Hangzhou, China. In Genet Mol Res, 2014
Five PPI networks were constructed from which hub genes were acquired, such as minichromosome maintenance complex component 7 (MCM7), MCM2, decorin (DCN), retinoblastoma 1 (RB1), and tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma (YWHAG).
Helicase loading: how to build a MCM2-7 double-hexamer.
Review
Speck et al., London, United Kingdom. In Semin Cell Dev Biol, 2014
A central step in eukaryotic initiation of DNA replication is the loading of the helicase at replication origins, misregulation of this reaction leads to DNA damage and genome instability.
Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers.
Impact
Hung et al., Houston, United States. In Cancer Cell, 2013
Here, we show that activated EGFR phosphorylates the p56 isoform of Lyn, p56(Lyn), at Y32, which then phosphorylates MCM7, a licensing factor critical for DNA replication, at Y600 to increase its association with other minichromosome maintenance complex proteins, thereby promoting DNA synthesis complex assembly and cell proliferation.
Viral and cellular biomarkers in the diagnosis of cervical intraepithelial neoplasia and cancer.
Review
Buonaguro et al., Napoli, Italy. In Biomed Res Int, 2012
This review will focus on the analysis of clinical validated or candidate biomarkers, such as HPV DNA, HPV E6/E7 mRNA, HPV proteins, p16(INK4a) and Ki67, TOP2A and MCM2 cellular factors, and DNA methylation profiles, which will likely improve the identification of premalignant lesions that have a high risk to evolve into invasive cervical cancer.
Mcm2 deficiency results in short deletions allowing high resolution identification of genes contributing to lymphoblastic lymphoma.
GeneRIF
Pruitt et al., Buffalo, United States. In Oncogene, 2012
Mcm2 deficiency results in short deletions allowing high resolution identification of genes contributing to lymphoblastic lymphoma.
Prognostic significance of MCM7 expression in the bronchial brushings of patients with non-small cell lung cancer (NSCLC).
GeneRIF
Wang et al., Beijing, China. In Lung Cancer, 2012
MCM7 and Ki67 in tumor tissues may be potential markers of a poor prognosis for non-small cell lung cancer patients
Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis.
GeneRIF
Hurwitz et al., New York City, United States. In Proc Natl Acad Sci U S A, 2012
Data show that using a 200-nt primed circular DNA substrate, the combined action of DNA polymerase epsilon and the Cdc45/Mcm2-7/GINS (CMG complex) leads to the formation of products >10 kb in length.
Analysis of performance characteristics of five cell cycle-related immunohistochemical markers and human papillomavirus genotyping in the diagnosis of cervical squamous cell carcinoma precursor lesions.
GeneRIF
Pérez-Guillermo et al., Cartagena, Spain. In Anal Quant Cytol Histol, 2012
ProEx C showed the best specificity; p16 displayed the highest sensitivity and area under receiver operating characteristic curve for squamous intraepithelial lesions diagnosis.
Ki-67 and MCM-2 in dental follicle and odontogenic cysts: the effects of inflammation on proliferative markers.
GeneRIF
Cabbar et al., İstanbul, Turkey. In Scientificworldjournal, 2011
The results of this study indicated that the higher MCM-2 expressions in RC than the KCOT might be related to the inflammation and this protein might be more sensitive to inflammation.
DNA damage-induced apoptosis and genetic background of the host: host-specific signaling enhancers of apoptosis.
Review
Kitagawa et al., Tokyo, Japan. In J Med Dent Sci, 2010
Interestingly, two host proteins, acinus and MCM2, were also associated with DNA-PK and gp70 and were host-specifically overexpressed in C3H-derived cells.
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