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CDC23 Cdc23p

Mcm10, CDC23, Dna43, Cdc23p
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MCM2, Ubiquitin, PCNA, APC, CAN
Papers on Mcm10
Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells.
New
Hickson et al., Copenhagen, Denmark. In Oncotarget, Jan 2016
In budding yeast, two essential replication factors, Sld2 and Mcm10, are then important for the activation of replication origins.
Effects of flavonoids on expression of genes involved in cell cycle regulation and DNA replication in human fibroblasts.
New
Gabig-Cimińska et al., Gdańsk, Poland. In Mol Cell Biochem, Sep 2015
It considerably reduced the efficiency of expression of genes coding for MCM2-7 and MCM10 helicases, as well as some other proteins involved in the S phase control.
iAID: an improved auxin-inducible degron system for the construction of a 'tight' conditional mutant in the budding yeast Saccharomyces cerevisiae.
New
Araki et al., Mishima, Japan. In Yeast, Aug 2015
To provide examples, we describe the construction of tight mutants of the replication factors Dpb11 and Mcm10, dpb11-iAID, and mcm10-iAID.
HIV-1 Vpr Protein Enhances Proteasomal Degradation of MCM10 DNA Replication Factor through the Cul4-DDB1[VprBP] E3 Ubiquitin Ligase to Induce G2/M Cell Cycle Arrest.
New
Allahbakhshi et al., Tehrān, Iran. In J Biol Chem, Aug 2015
In this study, we show that HIV-1 Vpr indirectly binds MCM10, a eukaryotic DNA replication factor, in a Vpr-binding protein (VprBP) (VprBP)-dependent manner.
The N-terminus of Mcm10 is important for interaction with the 9-1-1 clamp and in resistance to DNA damage.
Bielinsky et al., Minneapolis, United States. In Nucleic Acids Res, 2014
Accurate replication of the genome requires the evolutionarily conserved minichromosome maintenance protein, Mcm10.
MCM10: one tool for all-Integrity, maintenance and damage control.
Review
Bielinsky et al., Minneapolis, United States. In Semin Cell Dev Biol, 2014
Minichromsome maintenance protein 10 (Mcm10) is an essential replication factor that is required for the activation of the Cdc45:Mcm2-7:GINS helicase.
Minichromosome Maintenance (MCM) Family as potential diagnostic and prognostic tumor markers for human gliomas.
Bie et al., Changchun, China. In Bmc Cancer, 2013
MCM2-7 and MCM10 expressions were associated with WHO tumor grade.
Expression of miR-34c induces G2/M cell cycle arrest in breast cancer cells.
Larsson et al., Lund, Sweden. In Bmc Cancer, 2013
In addition, the levels of CDC23, an important mediator in mitotic progression, were suppressed following miR-34c expression, and siRNAs targeting CDC23 mimicked the effect of miR-34c on G2/M arrest.
Mcm10 plays a role in functioning of the eukaryotic replicative DNA helicase, Cdc45-Mcm-GINS.
GeneRIF
Kanemaki et al., Mishima, Japan. In Curr Biol, 2012
In the absence of Mcm10, a stable Cdc45-Mcm-GINS (CMG) complex was assembled at origins. However subsequent translocation of CMG, replication protein A loading to origins, and the intra-S checkpoint activation were severely diminished.
Targeted disruption of Mcm10 causes defective embryonic cell proliferation and early embryo lethality.
GeneRIF
Lee et al., South Korea. In Biochim Biophys Acta, 2011
Genetic evidence for an essential and non-redundant physiological role of MCM10 during murine peri-implantation development.
How APC/C-Cdc20 changes its substrate specificity in mitosis.
Impact
GeneRIF
Pines et al., Cambridge, United Kingdom. In Nat Cell Biol, 2011
Cdc20 requires APC3 and APC8 to bind and activate the APC/C when the spindle assembly checkpoint is satisfied, but only APC8 when active, and APC10 is crucial for the destruction of cyclin B1 and securin, but not cyclin A
CDC23 regulates cancer cell phenotype and is overexpressed in papillary thyroid cancer.
GeneRIF
Kebebew et al., Bethesda, United States. In Endocr Relat Cancer, 2010
CDC23 is a critical regulator of cell cycle and cell growth, may be involved in thyroid cancer initiation and progression, and may explain the different tumor biology observed by gender.
Solution NMR structure of the C-terminal DNA binding domain of Mcm10 reveals a conserved MCM motif.
GeneRIF
Eichman et al., Nashville, United States. In J Biol Chem, 2010
insight in the action of Mcm10 in the replisome
[The role of MCM proteins in cell proliferation and tumorigenesis].
Review
Dzięgiel et al., Wrocław, Poland. In Postepy Hig Med Dosw (online), 2009
There are also MCM1 and MCM10, which are important in DNA replication, but they do not possess the specific MCM box.
MCM proteins and DNA replication.
Review
Méchali et al., Montpellier, France. In Curr Opin Cell Biol, 2006
MCM1 and MCM10 are not related to this family, nor to each other, but also function in DNA synthesis.
Identification of a cullin homology region in a subunit of the anaphase-promoting complex.
Impact
Kirschner et al., Boston, United States. In Science, 1998
The anaphase-promoting complex is composed of eight protein subunits, including BimE (APC1), CDC27 (APC3), CDC16 (APC6), and CDC23 (APC8).
Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins.
Impact
Nasmyth et al., Vienna, Austria. In Science, 1998
At least 12 different subunits were detected in the purified particle from budding yeast, including the previously identified proteins Apc1p, Cdc16p, Cdc23p, Cdc26p, and Cdc27p.
Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae.
Impact
Nasmyth et al., Vienna, Austria. In Science, 1996
Entry into anaphase and proteolysis of B-type cyclins depend on a complex containing the tetratricopeptide repeat proteins Cdc16p, Cdc23p, and Cdc27p.
Identification of BIME as a subunit of the anaphase-promoting complex.
Impact
Kirschner et al., Boston, United States. In Science, 1996
In addition to CDC27, CDC16, and CDC23, APC contained a homolog of Aspergillus nidulans BIME, a protein essential for anaphase.
Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast.
Impact
Nasmyth et al., Vienna, Austria. In Cell, 1995
Through the isolation of mutants, we have identified three essential yeast genes, CDC16, CDC23, and CSE1, which are required for proteolysis of the B-type cyclin CLB2 but not of other unstable proteins.
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