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Myeloid cell leukemia sequence 1

Mcl-1
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: bcl-2, Bcl-xL, Bax, CAN, PrP
Papers using Mcl-1 antibodies
Cancer targeting Gene-Viro-Therapy of liver carcinoma by dual-regulated oncolytic adenovirus armed with TRAIL gene.
Supplier
Kim Baek, In PLoS ONE, 2010
... anti-Bak monoclonal antibody was purchased from Calbiochem (EMD Biosciences, California, USA); anti-actin polyclonal, anti-Bax and anti-Mcl-1 monoclonal antibodies from Santa Cruz (Santa Cruz Biotechnology, California, USA); anti-tubulin monoclonal ...
SUMO modification regulates the transcriptional activity of FLASH.
Supplier
Tsilibary Effie C., In PLoS ONE, 2008
... rabbit anti-cleaved caspase-3 (9664), rabbit anti-poly (ADP-ribose) polymerase, PARP (9542), rabbit anti-cleaved PARP (5625), rabbit anti-MCL-1 (5453) (Cell Signaling, Beverly, MA); mouse monoclonal ...
G3139, an anti-Bcl-2 antisense oligomer that binds heparin-binding growth factors and collagen I, alters in vitro endothelial cell growth and tubular morphogenesis
Supplier
Koch Troels et al., In Nucleic Acids Research, 2008
... The anti-poly(ADP-ribosyl)polymerase (PARP) monoclonal, anti-pro-caspase-3 monoclonal, anti-Bcl-xL polyclonal, anti-Mcl-1 polyclonal antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
The BCL-2 protein family: opposing activities that mediate cell death
Supplier
Kaufmann Scott H. et al., In The Journal of Cell Biology, 2007
... Antibodies to the following antigens were purchased from the indicated suppliers: Hsp60, Bim, Bad, and Mcl-1 from Cell Signaling Technology; cytochrome ...
Bcl2 inhibits abasic site repair by down-regulating APE1 endonuclease activity
Supplier
Deng Xingming et al., In Molecular Cancer, 2007
... Mcl-1, pERK, ERK1/2, Bim and tubulin antibodies as well as Mcl1 siRNA were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
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Papers on Mcl-1
Targeting the intrinsic apoptosis pathway as a strategy for melanoma therapy.
New
Haass et al., Australia. In Pigment Cell Melanoma Res, 21 Apr 2014
Studies using BH3-mimetics indicate that the anti-apoptotic BCL-2 protein MCL-1 and its antagonist NOXA are particularly important regulators of BCL-2 family signaling, while SMAC-mimetic studies show that both XIAP and the cIAPs must be targeted to effectively induce apoptosis of cancer cells.
Coupled Folding and Binding of the Disordered Protein PUMA does not Require Particular Residual Structure.
New
Clarke et al., In J Am Chem Soc, 21 Apr 2014
PUMA, of the BCL-2 family, is an IDP in isolation, but will form a single, contiguous α-helix upon binding the folded protein MCL-1.
Genetic association of gastric cancer with miRNA clusters including the cancer related genes MIR29, MIR25, MIR93 and MIR106: Results from the EPIC-EURGAST study.
New
Sala et al., Barcelona, Spain. In Int J Cancer, 18 Apr 2014
Some functionally validated target genes of these miRNAs are implicated in cancer-related processes such as methylation (DNMT3A, DNMT3B), cell cycle (E2F1, CDKN1A, CDKKN1C) apoptosis (BCL2L11, MCL1), angiogenesis (VEGFA) and progression (PIK3R1, MYCN).
MicroRNA-363-mediated downregulation of S1PR1 suppresses the proliferation of hepatocellular carcinoma cells.
New
He et al., Chongqing, China. In Cell Signal, 12 Apr 2014
Moreover, we found that the expression of downstream genes of ERK and STAT3, including PDGF-A, PDGF-B, MCL-1 and Bcl-xL, was suppressed after miR-363 transfection.
Concordance of Genomic Alterations Between Primary and Recurrent Breast Cancer.
New
Gonzalez-Angulo et al., Anderson, United States. In Mol Cancer Ther, 07 Apr 2014
Alterations were detected in 55 genes (mean 3.95 alterations/sample, range 1-12), including mutations in PIK3CA, TP53, ARID1A, PTEN, AKT1, NF1, FBXW7 and FGFR3 and amplifications in MCL1, CCND1, FGFR1, MYC, IGF1R, MDM2, MDM4, AKT3, CDK4, AKT2.
TCTP as therapeutic target in cancers.
Review
New
Rocchi et al., Marseille, France. In Cancer Treat Rev, 02 Apr 2014
TCTP interacts with itself and other protein including MCL1 and p53.
A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells.
New
Impact
Lieberman et al., Boston, United States. In Cancer Cell, Sep 2013
Proteasome addiction in basal-like TNBCs was mediated by NOXA and linked to MCL-1 dependence.
BH3 profiling--measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions.
Review
New
Letai et al., United States. In Cancer Lett, Jun 2013
BH3 profiling has proven useful in identifying and understanding cellular dependence on individual anti-apoptotic proteins like BCL-2 or MCL-1.
Delving deeper: MCL-1's contributions to normal and cancer biology.
Review
Opferman et al., Memphis, United States. In Trends Cell Biol, 2013
One family member, MCL-1, is unique because its expression is tightly regulated and it is essential for promoting the survival of myriad cellular lineages.
Targeting BCL2 family in human myeloid dendritic cells: a challenge to cure diseases with chronic inflammations associated with bone loss.
Review
Delprat et al., Stockholm, Sweden. In Clin Dev Immunol, 2012
We have recently documented that the proinflammatory cytokine IL-17A regulates long-term survival of DC by inducing BCL2A1 expression, in addition to the constitutive MCL1 expression.
Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling.
GeneRIF
Yokoyama et al., Kōchi, Japan. In Arterioscler Thromb Vasc Biol, 2012
Thrombomodulin upregulates extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling to protect endothelial cells from calcineurin inhibitor-induced toxicity.
N-α-acetyltransferase 10 protein inhibits apoptosis through RelA/p65-regulated MCL1 expression.
GeneRIF
Shou et al., Beijing, China. In Carcinogenesis, 2012
study revealed a novel mechanism controlling MCL1 expression, in which Naa10p and RelA/p65 synergistically interact with MCL1 promoter region and promote MCL1 transcription
Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration.
Impact
GeneRIF
Opferman et al., Memphis, United States. In Nat Cell Biol, 2012
report that different forms of MCL-1 reside in distinct mitochondrial locations and exhibit separable functions
Critical role for antiapoptotic Bcl-xL and Mcl-1 in human macrophage survival and cellular IAP1/2 (cIAP1/2) in resistance to HIV-Vpr-induced apoptosis.
GeneRIF
Kumar et al., Ottawa, Canada. In J Biol Chem, 2012
resistance to Vpr-induced apoptosis is specifically mediated by cIAP1/2 genes independent of Bcl-xL and Mcl-1, which play a key role in maintaining cell viability.
Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency.
Impact
Golub et al., Cambridge, United States. In Cancer Cell, 2012
MCL1, which encodes the antiapoptotic protein MCL1, is among the most frequently amplified genes in human cancer.
MYC directs transcription of MCL1 and eIF4E genes to control sensitivity of gastric cancer cells toward HDAC inhibitors.
GeneRIF
Schneider et al., München, Germany. In Cell Cycle, 2012
MCL1 expression levels inversely correlate with the responsiveness of gastric cancer cells toward HDACi.
Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease.
Impact
Humerickhouse et al., Melbourne, Australia. In J Clin Oncol, 2012
Low MCL1 expression and high BIM:MCL1 or BIM:BCL2 ratios in leukemic cells correlated with response.
Novel insights in molecular mechanisms of CLL.
Review
Pekarsky et al., Columbus, United States. In Curr Pharm Des, 2011
In indolent CLL characterized by 13q14 deletions, MiR-15/16 targeting BCL2 and MCL1 and DLEU7 targeting TNF pathway were proposed as tumor suppressors.
Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death.
Review
Impact
Wertz et al., San Francisco, United States. In Nat Rev Mol Cell Biol, 2011
For example, ubiquitin E3 ligases, such as MDM2 (which ubiquitylates p53) and inhibitor of apoptosis (IAP) proteins, and deubiquitinases, such as A20 and ubiquitin-specific protease 9X (USP9X) (which regulate the ubiquitylation and degradation of receptor-interacting protein 1 (RIP1) and myeloid leukaemia cell differentiation 1 (MCL1), respectively), have important roles in apoptosis.
More papers using Mcl-1 antibodies
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
Supplier
Idziorek T et al., In Oncogene, 2006
... The mouse MCL-1 antibody was purchased from Rockland (Philadelphia, PA, USA), and ...
Mitochondrial membrane permeabilization in cell death.
Supplier
Blanke Steven R., In PLoS Pathogens, 2006
... Santa Cruz Biotechnology (Santa Cruz, CA); g) mouse monoclonal anti-Bcl2 and rabbit polyclonal anti-Bcl-xL and anti-Mcl1, all from Santa Cruz Biotechnology; h) rabbit polyclonal against ...
Interleukin-22: A novel T- and NK-cell derived cytokine that regulates the biology of tissue cells
Supplier
Gao Bin et al., In International Journal of Biological Sciences, 2005
... Anti-Mcl-1 antibody (Abcam, Cambridge, MA), anti-VMP1 antibody ...
A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies.
Supplier
Jin Dong-Yan, In PLoS ONE, 2005
... Rabbit polyclonal anti-XIAP, anti-caspase-8, anti-Mcl-1, and anti-PARP antibodies and mouse monoclonal anti-survivin antibody were purchased from Cell Signaling Technology, Inc ...
Maintenance of the CD40-related immunodeficient response in hyper-IgM B cells immortalized with a LMP1-regulated mini-EBV.
Supplier
Khan Wasif N., In PLoS ONE, 2004
... Mouse anti-Bcl-2 mAb, anti-Bcl-xL rabbit polyclonal anti-Mcl-1 rabbit polyclonal antisera were obtained from Ancell, LabVision and Chemicon respectively ...
JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD
Supplier
Ellis L M et al., In British Journal of Cancer, 2003
... St Louis, MO, USA), polyclonal rabbit anti-DFF45 (BD Biosciences, San Diego, CA, USA), monoclonal mouse anti-MCL-1 (22; Santa Cruz Biotechnology), fluorescein isothiocyanate (FITC)-conjugated goat ...
Some precautions in using chelators to buffer metals in biological solutions
Supplier
Shirihai Orian S., In PLoS ONE, 2003
... MCL-1 rabbit polyclonal antibody was purchased from Abcam (Cambridge, MA) or from ...
Determining significant fold differences in gene expression analysis
Supplier
Koup Richard A, In PLoS Pathogens, 2000
... Antibodies to Bfl-1 and Mcl-1 were supplied by Cell Signaling Technologies ...
Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA
Supplier
Wang HongYang et al., In Molecular Cancer, 1995
... Purified anti-Mcl-1 antibody was from Biolegend.
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