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Myeloid cell leukemia sequence 1

Mcl-1
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: bcl-2, Bcl-xL, Bax, CAN, PrP
Papers using Mcl-1 antibodies
Cancer targeting Gene-Viro-Therapy of liver carcinoma by dual-regulated oncolytic adenovirus armed with TRAIL gene.
Supplier
Kim Baek, In PLoS ONE, 2010
... anti-Bak monoclonal antibody was purchased from Calbiochem (EMD Biosciences, California, USA); anti-actin polyclonal, anti-Bax and anti-Mcl-1 monoclonal antibodies from Santa Cruz (Santa Cruz Biotechnology, California, USA); anti-tubulin monoclonal ...
SUMO modification regulates the transcriptional activity of FLASH.
Supplier
Tsilibary Effie C., In PLoS ONE, 2008
... rabbit anti-cleaved caspase-3 (9664), rabbit anti-poly (ADP-ribose) polymerase, PARP (9542), rabbit anti-cleaved PARP (5625), rabbit anti-MCL-1 (5453) (Cell Signaling, Beverly, MA); mouse monoclonal ...
G3139, an anti-Bcl-2 antisense oligomer that binds heparin-binding growth factors and collagen I, alters in vitro endothelial cell growth and tubular morphogenesis
Supplier
Koch Troels et al., In Nucleic Acids Research, 2008
... The anti-poly(ADP-ribosyl)polymerase (PARP) monoclonal, anti-pro-caspase-3 monoclonal, anti-Bcl-xL polyclonal, anti-Mcl-1 polyclonal antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
The BCL-2 protein family: opposing activities that mediate cell death
Supplier
Kaufmann Scott H. et al., In The Journal of Cell Biology, 2007
... Antibodies to the following antigens were purchased from the indicated suppliers: Hsp60, Bim, Bad, and Mcl-1 from Cell Signaling Technology; cytochrome ...
Bcl2 inhibits abasic site repair by down-regulating APE1 endonuclease activity
Supplier
Deng Xingming et al., In Molecular Cancer, 2007
... Mcl-1, pERK, ERK1/2, Bim and tubulin antibodies as well as Mcl1 siRNA were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
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Papers on Mcl-1
Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein.
New
Gunning et al., Toronto, Canada. In Acs Med Chem Lett, 13 Dec 2014
Lead compound 13a, possessing a phosphotyrosyl-mimicking salicylic acid group, potently and selectively binds to STAT5 over STAT3, inhibits STAT5-SH2 domain complexation events in vitro, silences activated STAT5 in leukemic cells, as well as STAT5's downstream transcriptional targets, including MYC and MCL1, and, as a result, leads to apoptosis.
BCL2 protein signalling determines acute responses to neoadjuvant chemoradiotherapy in rectal cancer.
New
Prehn et al., Dublin, Ireland. In J Mol Med (berl), 13 Dec 2014
Systems modelling also demonstrated that rectal cancers depended on BCL2 rather than B cell lymphoma-extra large (BCL(X)L) or myeloid cell leukemia 1 (MCL1) for survival, suggesting that poor responders may benefit from therapy with selective BCL2 antagonists.
MCL-1 but not BCL-XL is critical for the development and sustained expansion of thymic lymphoma in p53-deficient mice.
New
Strasser et al., Melbourne, Australia. In Blood, 03 Dec 2014
Pro-survival MCL-1 is essential for survival of T cell progenitors, BCL-XL for immature thymocytes and BCL-2 for mature T cells.
DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis.
New
Impact
Hengartner et al., Zürich, Switzerland. In Nat Cell Biol, Aug 2014
Microtubule-targeting chemotherapeutics induce apoptosis in cancer cells by promoting the phosphorylation and degradation of the anti-apoptotic BCL-2 family member MCL1.
TCTP as therapeutic target in cancers.
Review
New
Rocchi et al., Marseille, France. In Cancer Treat Rev, Jul 2014
TCTP interacts with itself and other protein including MCL1 and p53.
Role of miR-15/16 in CLL.
Review
New
Croce et al., Columbus, United States. In Cell Death Differ, Jul 2014
miR-15/16 cluster targets multiple oncogenes, including BCL2, Cyclin D1, MCL1 and others.
miR-107 Activates ATR/Chk1 Pathway and Suppress Cervical Cancer Invasion by Targeting MCL1.
New
Yin et al., Shenyang, China. In Plos One, Dec 2013
Here we showed that miR-107 directly targeted MCL1 and activated ATR/Chk1 pathway to inhibit proliferation, migration and invasiveness of cervical cancer cells.
Anti-apoptotic BCL-2 family proteins in acute neural injury.
Review
New
Prehn et al., Dublin, Ireland. In Front Cell Neurosci, Dec 2013
We discuss overlapping and differential effects of the individual family members BCL-2, BCL-extra long (BCL-XL), myeloid cell leukemia 1 (MCL-1), and BCL2-like 2 (BCL-W) in the control of survival during development and pathophysiological processes such as trophic factor withdrawal, ischemic injury, excitotoxicity, oxidative stress and energy stress.
Silence of MCL-1 upstream signaling by shRNA abrogates multiple myeloma growth.
New
Deng et al., Xi'an, China. In Exp Hematol Oncol, Dec 2013
MCL-1 (myeloid cell leukemia sequence 1) protein is an anti-apoptotic molecule in MM cells and regulated by pro-inflammatory cytokine IL-6 and downstream signaling molecules STAT3, PI3K and MAPK.
Reprogramming cell death: BCL2 family inhibition in hematological malignancies.
Review
New
Ghia et al., Milano, Italy. In Immunol Lett, Sep 2013
The BCL2 family members play a central role in regulating programmed cell death (apoptosis) and arbitrating the cellular fate through an accurate balance between pro-apoptotic (BAX, BAK, and BH3-only proteins) and pro-survival (BCL2 and its closest homologues, BCLXL, BCLW and MCL-1) factors.
BH3 mimetics: status of the field and new developments.
Review
New
Billard, Paris, France. In Mol Cancer Ther, Sep 2013
The prototype BH3 mimetic ABT-737 selectively targets the three prosurvival proteins BCL-XL, BCL-2, and BCL-W (but not MCL-1 or A1) and its oral derivative ABT-263 has proved promising in clinical trials.
A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells.
New
Impact
Lieberman et al., Boston, United States. In Cancer Cell, Sep 2013
Proteasome addiction in basal-like TNBCs was mediated by NOXA and linked to MCL-1 dependence.
Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling.
GeneRIF
Yokoyama et al., Kōchi, Japan. In Arterioscler Thromb Vasc Biol, 2012
Thrombomodulin upregulates extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling to protect endothelial cells from calcineurin inhibitor-induced toxicity.
N-α-acetyltransferase 10 protein inhibits apoptosis through RelA/p65-regulated MCL1 expression.
GeneRIF
Shou et al., Beijing, China. In Carcinogenesis, 2012
study revealed a novel mechanism controlling MCL1 expression, in which Naa10p and RelA/p65 synergistically interact with MCL1 promoter region and promote MCL1 transcription
Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration.
Impact
GeneRIF
Opferman et al., Memphis, United States. In Nat Cell Biol, 2012
report that different forms of MCL-1 reside in distinct mitochondrial locations and exhibit separable functions
Critical role for antiapoptotic Bcl-xL and Mcl-1 in human macrophage survival and cellular IAP1/2 (cIAP1/2) in resistance to HIV-Vpr-induced apoptosis.
GeneRIF
Kumar et al., Ottawa, Canada. In J Biol Chem, 2012
resistance to Vpr-induced apoptosis is specifically mediated by cIAP1/2 genes independent of Bcl-xL and Mcl-1, which play a key role in maintaining cell viability.
Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency.
Impact
Golub et al., Cambridge, United States. In Cancer Cell, 2012
MCL1, which encodes the antiapoptotic protein MCL1, is among the most frequently amplified genes in human cancer.
MYC directs transcription of MCL1 and eIF4E genes to control sensitivity of gastric cancer cells toward HDAC inhibitors.
GeneRIF
Schneider et al., München, Germany. In Cell Cycle, 2012
MCL1 expression levels inversely correlate with the responsiveness of gastric cancer cells toward HDACi.
Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease.
Impact
Humerickhouse et al., Melbourne, Australia. In J Clin Oncol, 2012
Low MCL1 expression and high BIM:MCL1 or BIM:BCL2 ratios in leukemic cells correlated with response.
More papers using Mcl-1 antibodies
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
Supplier
Idziorek T et al., In Oncogene, 2006
... The mouse MCL-1 antibody was purchased from Rockland (Philadelphia, PA, USA), and ...
Mitochondrial membrane permeabilization in cell death.
Supplier
Blanke Steven R., In PLoS Pathogens, 2006
... Santa Cruz Biotechnology (Santa Cruz, CA); g) mouse monoclonal anti-Bcl2 and rabbit polyclonal anti-Bcl-xL and anti-Mcl1, all from Santa Cruz Biotechnology; h) rabbit polyclonal against ...
Interleukin-22: A novel T- and NK-cell derived cytokine that regulates the biology of tissue cells
Supplier
Gao Bin et al., In International Journal of Biological Sciences, 2005
... Anti-Mcl-1 antibody (Abcam, Cambridge, MA), anti-VMP1 antibody ...
A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies.
Supplier
Jin Dong-Yan, In PLoS ONE, 2005
... Rabbit polyclonal anti-XIAP, anti-caspase-8, anti-Mcl-1, and anti-PARP antibodies and mouse monoclonal anti-survivin antibody were purchased from Cell Signaling Technology, Inc ...
Maintenance of the CD40-related immunodeficient response in hyper-IgM B cells immortalized with a LMP1-regulated mini-EBV.
Supplier
Khan Wasif N., In PLoS ONE, 2004
... Mouse anti-Bcl-2 mAb, anti-Bcl-xL rabbit polyclonal anti-Mcl-1 rabbit polyclonal antisera were obtained from Ancell, LabVision and Chemicon respectively ...
JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD
Supplier
Ellis L M et al., In British Journal of Cancer, 2003
... St Louis, MO, USA), polyclonal rabbit anti-DFF45 (BD Biosciences, San Diego, CA, USA), monoclonal mouse anti-MCL-1 (22; Santa Cruz Biotechnology), fluorescein isothiocyanate (FITC)-conjugated goat ...
Some precautions in using chelators to buffer metals in biological solutions
Supplier
Shirihai Orian S., In PLoS ONE, 2003
... MCL-1 rabbit polyclonal antibody was purchased from Abcam (Cambridge, MA) or from ...
Determining significant fold differences in gene expression analysis
Supplier
Koup Richard A, In PLoS Pathogens, 2000
... Antibodies to Bfl-1 and Mcl-1 were supplied by Cell Signaling Technologies ...
Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA
Supplier
Wang HongYang et al., In Molecular Cancer, 1995
... Purified anti-Mcl-1 antibody was from Biolegend.
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