Targeting the intrinsic apoptosis pathway as a strategy for melanoma therapy.
Australia. In Pigment Cell Melanoma Res, 21 Apr 2014
Studies using BH3-mimetics indicate that the anti-apoptotic BCL-2 protein MCL-1 and its antagonist NOXA are particularly important regulators of BCL-2 family signaling, while SMAC-mimetic studies show that both XIAP and the cIAPs must be targeted to effectively induce apoptosis of cancer cells.
Genetic association of gastric cancer with miRNA clusters including the cancer related genes MIR29, MIR25, MIR93 and MIR106: Results from the EPIC-EURGAST study.
Barcelona, Spain. In Int J Cancer, 18 Apr 2014
Some functionally validated target genes of these miRNAs are implicated in cancer-related processes such as methylation (DNMT3A, DNMT3B), cell cycle (E2F1, CDKN1A, CDKKN1C) apoptosis (BCL2L11, MCL1), angiogenesis (VEGFA) and progression (PIK3R1, MYCN).
Concordance of Genomic Alterations Between Primary and Recurrent Breast Cancer.
Anderson, United States. In Mol Cancer Ther, 07 Apr 2014
Alterations were detected in 55 genes (mean 3.95 alterations/sample, range 1-12), including mutations in PIK3CA, TP53, ARID1A, PTEN, AKT1, NF1, FBXW7 and FGFR3 and amplifications in MCL1, CCND1, FGFR1, MYC, IGF1R, MDM2, MDM4, AKT3, CDK4, AKT2.
Novel insights in molecular mechanisms of CLL.
Columbus, United States. In Curr Pharm Des, 2011
In indolent CLL characterized by 13q14 deletions, MiR-15/16 targeting BCL2 and MCL1 and DLEU7 targeting TNF pathway were proposed as tumor suppressors.
Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death.
More papers using
San Francisco, United States. In Nat Rev Mol Cell Biol, 2011
For example, ubiquitin E3 ligases, such as MDM2 (which ubiquitylates p53) and inhibitor of apoptosis (IAP) proteins, and deubiquitinases, such as A20 and ubiquitin-specific protease 9X (USP9X) (which regulate the ubiquitylation and degradation of receptor-interacting protein 1 (RIP1) and myeloid leukaemia cell differentiation 1 (MCL1), respectively), have important roles in apoptosis.