Thyroid hormone and anti-apoptosis in tumor cells.
Taipei, Taiwan. In Oncotarget, 20 Jul 2015
In a nanoparticulate formulation limiting its action to αvβ3, tetrac modulates integrin-dependent effects on gene expression in human cancer cell lines that include increased expression of a panel of pro-apoptotic genes and decreased transcription of defensive anti-apoptotic XIAP and MCL1 genes.
MicroRNAs in B-cell lymphomas: how a complex biology gets more complex.
Brno, Czech Republic. In Leukemia, May 2015
We focus on miR-contribution to the regulation of important signalling pathways (such as NF-κB, PI3K/AKT and TGF-β), BCR signalling and its modulators (such as PTEN, SHIP-1, ZAP-70, GAB1 and BTK), anti- and pro-apoptotic proteins (such as BCL2, MCL1, TCL1, BIM, p53 and SIRT1) and transcription factors (such as MYC, MYB, PU.1, FOXP1 and BCL6).
Role of miR-15/16 in CLL.
Columbus, United States. In Cell Death Differ, Jan 2015
miR-15/16 cluster targets multiple oncogenes, including BCL2, Cyclin D1, MCL1 and others.
Anti-apoptotic BCL-2 family proteins in acute neural injury.
More papers using
Dublin, Ireland. In Front Cell Neurosci, 2013
We discuss overlapping and differential effects of the individual family members BCL-2, BCL-extra long (BCL-XL), myeloid cell leukemia 1 (MCL-1), and BCL2-like 2 (BCL-W) in the control of survival during development and pathophysiological processes such as trophic factor withdrawal, ischemic injury, excitotoxicity, oxidative stress and energy stress.