Anti-apoptotic BCL-2 family proteins in acute neural injury.
Dublin, Ireland. In Front Cell Neurosci, Dec 2013
We discuss overlapping and differential effects of the individual family members BCL-2, BCL-extra long (BCL-XL), myeloid cell leukemia 1 (MCL-1), and BCL2-like 2 (BCL-W) in the control of survival during development and pathophysiological processes such as trophic factor withdrawal, ischemic injury, excitotoxicity, oxidative stress and energy stress.
Reprogramming cell death: BCL2 family inhibition in hematological malignancies.
Milano, Italy. In Immunol Lett, Sep 2013
The BCL2 family members play a central role in regulating programmed cell death (apoptosis) and arbitrating the cellular fate through an accurate balance between pro-apoptotic (BAX, BAK, and BH3-only proteins) and pro-survival (BCL2 and its closest homologues, BCLXL, BCLW and MCL-1) factors.
BH3 mimetics: status of the field and new developments.
More papers using
Paris, France. In Mol Cancer Ther, Sep 2013
The prototype BH3 mimetic ABT-737 selectively targets the three prosurvival proteins BCL-XL, BCL-2, and BCL-W (but not MCL-1 or A1) and its oral derivative ABT-263 has proved promising in clinical trials.