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Myeloid cell leukemia sequence 1

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: bcl-2, Bcl-xL, Bax, CAN, PrP
Papers using Mcl-1 antibodies
Cancer targeting Gene-Viro-Therapy of liver carcinoma by dual-regulated oncolytic adenovirus armed with TRAIL gene.
Kim Baek, In PLoS ONE, 2010
... anti-Bak monoclonal antibody was purchased from Calbiochem (EMD Biosciences, California, USA); anti-actin polyclonal, anti-Bax and anti-Mcl-1 monoclonal antibodies from Santa Cruz (Santa Cruz Biotechnology, California, USA); anti-tubulin monoclonal ...
SUMO modification regulates the transcriptional activity of FLASH.
Tsilibary Effie C., In PLoS ONE, 2008
... rabbit anti-cleaved caspase-3 (9664), rabbit anti-poly (ADP-ribose) polymerase, PARP (9542), rabbit anti-cleaved PARP (5625), rabbit anti-MCL-1 (5453) (Cell Signaling, Beverly, MA); mouse monoclonal ...
G3139, an anti-Bcl-2 antisense oligomer that binds heparin-binding growth factors and collagen I, alters in vitro endothelial cell growth and tubular morphogenesis
Koch Troels et al., In Nucleic Acids Research, 2008
... The anti-poly(ADP-ribosyl)polymerase (PARP) monoclonal, anti-pro-caspase-3 monoclonal, anti-Bcl-xL polyclonal, anti-Mcl-1 polyclonal antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
The BCL-2 protein family: opposing activities that mediate cell death
Kaufmann Scott H. et al., In The Journal of Cell Biology, 2007
... Antibodies to the following antigens were purchased from the indicated suppliers: Hsp60, Bim, Bad, and Mcl-1 from Cell Signaling Technology; cytochrome ...
Bcl2 inhibits abasic site repair by down-regulating APE1 endonuclease activity
Deng Xingming et al., In Molecular Cancer, 2007
... Mcl-1, pERK, ERK1/2, Bim and tubulin antibodies as well as Mcl1 siRNA were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
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Papers on Mcl-1
Activation-Induced Cytidine Deaminase Expression in Human B Cell Precursors Is Essential for Central B Cell Tolerance.
Meffre et al., New Haven, United States. In Immunity, 02 Dec 2015
However, most AID(+) immature B cells lacked anti-apoptotic MCL-1 and were deleted by apoptosis.
[The myeloid cell leukemia-1 mRNA splicing mediated by epithelial splicing regulatory protein 1 (ESRP1) in glioma U251 cell lines].
Zhang et al., Shanghai, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 30 Nov 2015
To investigate the regulatory mechanism of myeloid cell leukemia-1 (MCL1) mRNA splicing mediated by epithelial splicing regulatory protein 1 (ESRP1) in glioma U251 cell lines.
Epigenetic silencing of tumor suppressor miR-3151 contributes to Chinese chronic lymphocytic leukemia by constitutive activation of MADD/ERK and PIK3R2/AKT signaling pathways.
Chim et al., Hong Kong, Hong Kong. In Oncotarget, 27 Nov 2015
Moreover, restoration of miR-3151 resulted in inhibition of cellular proliferation and enhanced apoptosis, repression of MADD and PIK3R2, downregulation of MEK/ERK and PI3K/AKT signaling, and repression of MCL1.
An interconnected hierarchical model of cell death regulation by the BCL-2 family.
Cheng et al., Kettering, United States. In Nat Cell Biol, 31 Oct 2015
BCL-2, BCL-XL and MCL-1 inhibit both modes of BAX-BAK activation by sequestering activator BH3s and 'BH3-exposed' monomers of BAX-BAK, respectively.
Attacking Cancer's Achilles Heel: Antagonism of Anti-Apoptotic BCL-2 Family Members.
Opferman, Memphis, United States. In Febs J, Sep 2015
To escape such death inducing signals, cancer cells often select for up regulation of anti-apoptotic BCL-2 family members including BCL-2, BCL-XL , BFL-1, BCL-W, and MCL-1.
Thyroid hormone and anti-apoptosis in tumor cells.
Davis et al., Taipei, Taiwan. In Oncotarget, Jul 2015
In a nanoparticulate formulation limiting its action to αvβ3, tetrac modulates integrin-dependent effects on gene expression in human cancer cell lines that include increased expression of a panel of pro-apoptotic genes and decreased transcription of defensive anti-apoptotic XIAP and MCL1 genes.
MicroRNAs in B-cell lymphomas: how a complex biology gets more complex.
Mraz et al., Brno, Czech Republic. In Leukemia, May 2015
We focus on miR-contribution to the regulation of important signalling pathways (such as NF-κB, PI3K/AKT and TGF-β), BCR signalling and its modulators (such as PTEN, SHIP-1, ZAP-70, GAB1 and BTK), anti- and pro-apoptotic proteins (such as BCL2, MCL1, TCL1, BIM, p53 and SIRT1) and transcription factors (such as MYC, MYB, PU.1, FOXP1 and BCL6).
Role of miR-15/16 in CLL.
Croce et al., Columbus, United States. In Cell Death Differ, Jan 2015
miR-15/16 cluster targets multiple oncogenes, including BCL2, Cyclin D1, MCL1 and others.
Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways.
Murray et al., Memphis, United States. In Immunity, Jan 2015
Development of the granulocyte subset requires MCL-1-mediated control of the intrinsic mitochondrial death pathway.
miR-125b Suppresses Proliferation and Invasion by Targeting MCL1 in Gastric Cancer.
He et al., Hengyang, China. In Biomed Res Int, Dec 2014
miR-125b elicits these responses by directly targeting MCL1 (myeloid cell leukemia 1), which results in a marked reduction in MCL1 expression.
miR-193b Modulates Resistance to Doxorubicin in Human Breast Cancer Cells by Downregulating MCL-1.
Meng et al., Hangzhou, China. In Biomed Res Int, Dec 2014
The aim of this study was to investigate whether miR-193b mediated the resistance of breast cancer cells to doxorubicin by targeting myeloid cell leukemia-1 (MCL-1).
DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis.
Hengartner et al., Zürich, Switzerland. In Nat Cell Biol, Aug 2014
Microtubule-targeting chemotherapeutics induce apoptosis in cancer cells by promoting the phosphorylation and degradation of the anti-apoptotic BCL-2 family member MCL1.
Anti-apoptotic BCL-2 family proteins in acute neural injury.
Prehn et al., Dublin, Ireland. In Front Cell Neurosci, 2013
We discuss overlapping and differential effects of the individual family members BCL-2, BCL-extra long (BCL-XL), myeloid cell leukemia 1 (MCL-1), and BCL2-like 2 (BCL-W) in the control of survival during development and pathophysiological processes such as trophic factor withdrawal, ischemic injury, excitotoxicity, oxidative stress and energy stress.
Targeting BCL2-Proteins for the Treatment of Solid Tumours.
Vogler, Leicester, United Kingdom. In Adv Med, 2013
To this end, several strategies have been developed to inhibit BCL2, BCL-XL, BCL-w, and MCL1.
A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells.
Lieberman et al., Boston, United States. In Cancer Cell, 2013
Proteasome addiction in basal-like TNBCs was mediated by NOXA and linked to MCL-1 dependence.
Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling.
Yokoyama et al., Kōchi, Japan. In Arterioscler Thromb Vasc Biol, 2012
Thrombomodulin upregulates extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling to protect endothelial cells from calcineurin inhibitor-induced toxicity.
N-α-acetyltransferase 10 protein inhibits apoptosis through RelA/p65-regulated MCL1 expression.
Shou et al., Beijing, China. In Carcinogenesis, 2012
study revealed a novel mechanism controlling MCL1 expression, in which Naa10p and RelA/p65 synergistically interact with MCL1 promoter region and promote MCL1 transcription
Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration.
Opferman et al., Memphis, United States. In Nat Cell Biol, 2012
report that different forms of MCL-1 reside in distinct mitochondrial locations and exhibit separable functions
Critical role for antiapoptotic Bcl-xL and Mcl-1 in human macrophage survival and cellular IAP1/2 (cIAP1/2) in resistance to HIV-Vpr-induced apoptosis.
Kumar et al., Ottawa, Canada. In J Biol Chem, 2012
resistance to Vpr-induced apoptosis is specifically mediated by cIAP1/2 genes independent of Bcl-xL and Mcl-1, which play a key role in maintaining cell viability.
MYC directs transcription of MCL1 and eIF4E genes to control sensitivity of gastric cancer cells toward HDAC inhibitors.
Schneider et al., München, Germany. In Cell Cycle, 2012
MCL1 expression levels inversely correlate with the responsiveness of gastric cancer cells toward HDACi.
More papers using Mcl-1 antibodies
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
Idziorek T et al., In Oncogene, 2006
... The mouse MCL-1 antibody was purchased from Rockland (Philadelphia, PA, USA), and ...
Mitochondrial membrane permeabilization in cell death.
Blanke Steven R., In PLoS Pathogens, 2006
... Santa Cruz Biotechnology (Santa Cruz, CA); g) mouse monoclonal anti-Bcl2 and rabbit polyclonal anti-Bcl-xL and anti-Mcl1, all from Santa Cruz Biotechnology; h) rabbit polyclonal against ...
Interleukin-22: A novel T- and NK-cell derived cytokine that regulates the biology of tissue cells
Gao Bin et al., In International Journal of Biological Sciences, 2005
... Anti-Mcl-1 antibody (Abcam, Cambridge, MA), anti-VMP1 antibody ...
A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies.
Jin Dong-Yan, In PLoS ONE, 2005
... Rabbit polyclonal anti-XIAP, anti-caspase-8, anti-Mcl-1, and anti-PARP antibodies and mouse monoclonal anti-survivin antibody were purchased from Cell Signaling Technology, Inc ...
Maintenance of the CD40-related immunodeficient response in hyper-IgM B cells immortalized with a LMP1-regulated mini-EBV.
Khan Wasif N., In PLoS ONE, 2004
... Mouse anti-Bcl-2 mAb, anti-Bcl-xL rabbit polyclonal anti-Mcl-1 rabbit polyclonal antisera were obtained from Ancell, LabVision and Chemicon respectively ...
JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD
Ellis L M et al., In British Journal of Cancer, 2003
... St Louis, MO, USA), polyclonal rabbit anti-DFF45 (BD Biosciences, San Diego, CA, USA), monoclonal mouse anti-MCL-1 (22; Santa Cruz Biotechnology), fluorescein isothiocyanate (FITC)-conjugated goat ...
Some precautions in using chelators to buffer metals in biological solutions
Shirihai Orian S., In PLoS ONE, 2003
... MCL-1 rabbit polyclonal antibody was purchased from Abcam (Cambridge, MA) or from ...
Determining significant fold differences in gene expression analysis
Koup Richard A, In PLoS Pathogens, 2000
... Antibodies to Bfl-1 and Mcl-1 were supplied by Cell Signaling Technologies ...
Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA
Wang HongYang et al., In Molecular Cancer, 1995
... Purified anti-Mcl-1 antibody was from Biolegend.
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