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Myeloid cell leukemia sequence 1

Mcl-1
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: bcl-2, Bcl-xL, Bax, CAN, PrP
Papers using Mcl-1 antibodies
Cancer targeting Gene-Viro-Therapy of liver carcinoma by dual-regulated oncolytic adenovirus armed with TRAIL gene.
Supplier
Kim Baek, In PLoS ONE, 2010
... anti-Bak monoclonal antibody was purchased from Calbiochem (EMD Biosciences, California, USA); anti-actin polyclonal, anti-Bax and anti-Mcl-1 monoclonal antibodies from Santa Cruz (Santa Cruz Biotechnology, California, USA); anti-tubulin monoclonal ...
SUMO modification regulates the transcriptional activity of FLASH.
Supplier
Tsilibary Effie C., In PLoS ONE, 2008
... rabbit anti-cleaved caspase-3 (9664), rabbit anti-poly (ADP-ribose) polymerase, PARP (9542), rabbit anti-cleaved PARP (5625), rabbit anti-MCL-1 (5453) (Cell Signaling, Beverly, MA); mouse monoclonal ...
G3139, an anti-Bcl-2 antisense oligomer that binds heparin-binding growth factors and collagen I, alters in vitro endothelial cell growth and tubular morphogenesis
Supplier
Koch Troels et al., In Nucleic Acids Research, 2008
... The anti-poly(ADP-ribosyl)polymerase (PARP) monoclonal, anti-pro-caspase-3 monoclonal, anti-Bcl-xL polyclonal, anti-Mcl-1 polyclonal antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
The BCL-2 protein family: opposing activities that mediate cell death
Supplier
Kaufmann Scott H. et al., In The Journal of Cell Biology, 2007
... Antibodies to the following antigens were purchased from the indicated suppliers: Hsp60, Bim, Bad, and Mcl-1 from Cell Signaling Technology; cytochrome ...
Bcl2 inhibits abasic site repair by down-regulating APE1 endonuclease activity
Supplier
Deng Xingming et al., In Molecular Cancer, 2007
... Mcl-1, pERK, ERK1/2, Bim and tubulin antibodies as well as Mcl1 siRNA were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
more suppliers
Papers on Mcl-1
Identifying molecular subtypes in human colon cancer using gene expression and DNA methylation microarray data.
New
Li et al., Guangzhou, China. In Int J Oncol, 29 Feb 2016
At DNA methylation level, we uncovered three major subtypes, MCL1 (methylation cluster 1), MCL2 (methylation cluster 2) and MCL3 (methylation cluster 3).
Induced Apoptosis Investigation in Wild-Type and FLT3-ITD Acute Myeloid Leukemia Cells by Nanochannel Electroporation and Single Cell qRT-PCR.
New
Lee et al., Columbus, United States. In Mol Ther, 19 Feb 2016
NEP, together with single cell qRT-PCR, led to an observation showing nearly 20 folds more Mcl-1 siRNA than MCL1 mRNA were required to induce cell death for both cell lines and patient blasts, i.e. ~8800 siRNAs for ~500±50 mRNAs in ITD cells and ~6000 siRNAs for ~300±50 mRNAs in WT cells.
A NOXA/MCL-1 Imbalance Underlies Chemoresistance of Malignant Rhabdoid Tumor Cells.
New
Hosoi et al., Kyoto, Japan. In J Cell Physiol, 17 Jan 2016
Previously, we showed that SNF5 contributes to transcriptional activation of NOXA, a pro-apoptotic protein that binds and inhibits the anti-apoptotic protein MCL-1.
Combination of galectin inhibitor GCS-100 and BH3 mimetics eliminates both p53 wild type and p53 null AML cells.
New
Andreeff et al., Houston, United States. In Biochim Biophys Acta, 17 Jan 2016
The agent reduced MCL-1 expression suggesting that GCS-100 could be more effective when combined with a BH3 mimetic.
Leishmania donovani exploits myeloid cell leukemia 1 (MCL-1) protein to prevent mitochondria dependent host cell apoptosis.
New
Ukil et al., Calcutta, India. In J Biol Chem, 15 Jan 2016
In the present study, with the help of in vitro and in vivo approaches, we documented that the macrophage anti-apoptotic protein myeloid cell leukemia 1 (MCL-1) is exploited by the intra-macrophage parasite Leishmania donovani to protect their "home" from actinomycin D-induced mitochondria-dependent apoptosis.
Targeting glutamine metabolism in multiple myeloma enhances BIM binding to BCL-2 eliciting synthetic lethality to venetoclax.
New
Shanmugam et al., Atlanta, United States. In Oncogene, 07 Jan 2016
We and others have demonstrated that glucose maintains levels of key resistance-promoting BCL-2 family member, myeloid cell leukemic factor 1 (MCL-1).
Upregulation of the MCL-1S protein variant following dihydroartemisinin treatment induces apoptosis in cholangiocarcinoma cells.
New
Li et al., Chongqing, China. In Oncol Lett, 31 Dec 2015
DHA treatment increased the ratio of MCL-1S/MCL-1L protein, thus inducing apoptosis in cholangiocarcinoma cells.
[Mechanisms of Apoptosis Induced by FTY720 in Multiple Myeloma Cell Line U266].
New
Liu et al., Shenyang, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 31 Dec 2015
U266 cells were treated with 0, 5, 10 and 20 µmol/L of FTY720 for 24 hours, the expressions of MCL-1, survivin, BCL-2, BID, BAX, BAK, P-ERK were tested by Western blot.
Effect of Co-transfection of Anti-myostatin shRNA Constructs in Caprine Fetal Fibroblast Cells.
New
Sarkhel et al., Jabalpur, India. In Anim Biotechnol, 31 Dec 2015
Simultaneously, we also monitored the induction of IFN responsive genes (IFN), pro-apoptotic gene (caspase3) and anti-apoptotic gene (MCL-1) due to cotransfection of different anti-MSTN shRNA constructs.
Activation-Induced Cytidine Deaminase Expression in Human B Cell Precursors Is Essential for Central B Cell Tolerance.
New
Impact
Meffre et al., New Haven, United States. In Immunity, 17 Dec 2015
However, most AID(+) immature B cells lacked anti-apoptotic MCL-1 and were deleted by apoptosis.
An interconnected hierarchical model of cell death regulation by the BCL-2 family.
New
Impact
Cheng et al., Kettering, United States. In Nat Cell Biol, Oct 2015
BCL-2, BCL-XL and MCL-1 inhibit both modes of BAX-BAK activation by sequestering activator BH3s and 'BH3-exposed' monomers of BAX-BAK, respectively.
Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways.
Impact
Murray et al., Memphis, United States. In Immunity, 2015
Development of the granulocyte subset requires MCL-1-mediated control of the intrinsic mitochondrial death pathway.
Differential Effects of β-Blockers, Angiotensin II Receptor Blockers, and a Novel AT2R Agonist NP-6A4 on Stress Response of Nutrient-Starved Cardiovascular Cells.
Pulakat et al., Columbia, United States. In Plos One, 2014
Myeloid Cell Leukemia 1 (MCL-1) is a protein critical for cardiovascular cell survival and implicated in cell adhesion.
DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis.
Impact
Hengartner et al., Zürich, Switzerland. In Nat Cell Biol, 2014
Microtubule-targeting chemotherapeutics induce apoptosis in cancer cells by promoting the phosphorylation and degradation of the anti-apoptotic BCL-2 family member MCL1.
A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells.
Impact
Lieberman et al., Boston, United States. In Cancer Cell, 2013
Proteasome addiction in basal-like TNBCs was mediated by NOXA and linked to MCL-1 dependence.
Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling.
GeneRIF
Yokoyama et al., Kōchi, Japan. In Arterioscler Thromb Vasc Biol, 2012
Thrombomodulin upregulates extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling to protect endothelial cells from calcineurin inhibitor-induced toxicity.
N-α-acetyltransferase 10 protein inhibits apoptosis through RelA/p65-regulated MCL1 expression.
GeneRIF
Shou et al., Beijing, China. In Carcinogenesis, 2012
study revealed a novel mechanism controlling MCL1 expression, in which Naa10p and RelA/p65 synergistically interact with MCL1 promoter region and promote MCL1 transcription
Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration.
Impact
GeneRIF
Opferman et al., Memphis, United States. In Nat Cell Biol, 2012
report that different forms of MCL-1 reside in distinct mitochondrial locations and exhibit separable functions
Critical role for antiapoptotic Bcl-xL and Mcl-1 in human macrophage survival and cellular IAP1/2 (cIAP1/2) in resistance to HIV-Vpr-induced apoptosis.
GeneRIF
Kumar et al., Ottawa, Canada. In J Biol Chem, 2012
resistance to Vpr-induced apoptosis is specifically mediated by cIAP1/2 genes independent of Bcl-xL and Mcl-1, which play a key role in maintaining cell viability.
MYC directs transcription of MCL1 and eIF4E genes to control sensitivity of gastric cancer cells toward HDAC inhibitors.
GeneRIF
Schneider et al., München, Germany. In Cell Cycle, 2012
MCL1 expression levels inversely correlate with the responsiveness of gastric cancer cells toward HDACi.
More papers using Mcl-1 antibodies
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
Supplier
Idziorek T et al., In Oncogene, 2006
... The mouse MCL-1 antibody was purchased from Rockland (Philadelphia, PA, USA), and ...
Mitochondrial membrane permeabilization in cell death.
Supplier
Blanke Steven R., In PLoS Pathogens, 2006
... Santa Cruz Biotechnology (Santa Cruz, CA); g) mouse monoclonal anti-Bcl2 and rabbit polyclonal anti-Bcl-xL and anti-Mcl1, all from Santa Cruz Biotechnology; h) rabbit polyclonal against ...
Interleukin-22: A novel T- and NK-cell derived cytokine that regulates the biology of tissue cells
Supplier
Gao Bin et al., In International Journal of Biological Sciences, 2005
... Anti-Mcl-1 antibody (Abcam, Cambridge, MA), anti-VMP1 antibody ...
A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies.
Supplier
Jin Dong-Yan, In PLoS ONE, 2005
... Rabbit polyclonal anti-XIAP, anti-caspase-8, anti-Mcl-1, and anti-PARP antibodies and mouse monoclonal anti-survivin antibody were purchased from Cell Signaling Technology, Inc ...
Maintenance of the CD40-related immunodeficient response in hyper-IgM B cells immortalized with a LMP1-regulated mini-EBV.
Supplier
Khan Wasif N., In PLoS ONE, 2004
... Mouse anti-Bcl-2 mAb, anti-Bcl-xL rabbit polyclonal anti-Mcl-1 rabbit polyclonal antisera were obtained from Ancell, LabVision and Chemicon respectively ...
JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD
Supplier
Ellis L M et al., In British Journal of Cancer, 2003
... St Louis, MO, USA), polyclonal rabbit anti-DFF45 (BD Biosciences, San Diego, CA, USA), monoclonal mouse anti-MCL-1 (22; Santa Cruz Biotechnology), fluorescein isothiocyanate (FITC)-conjugated goat ...
Some precautions in using chelators to buffer metals in biological solutions
Supplier
Shirihai Orian S., In PLoS ONE, 2003
... MCL-1 rabbit polyclonal antibody was purchased from Abcam (Cambridge, MA) or from ...
Determining significant fold differences in gene expression analysis
Supplier
Koup Richard A, In PLoS Pathogens, 2000
... Antibodies to Bfl-1 and Mcl-1 were supplied by Cell Signaling Technologies ...
Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA
Supplier
Wang HongYang et al., In Molecular Cancer, 1995
... Purified anti-Mcl-1 antibody was from Biolegend.
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