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Myeloid cell leukemia sequence 1

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: bcl-2, Bcl-xL, Bax, CAN, PrP
Papers using Mcl-1 antibodies
Cancer targeting Gene-Viro-Therapy of liver carcinoma by dual-regulated oncolytic adenovirus armed with TRAIL gene.
Kim Baek, In PLoS ONE, 2010
... anti-Bak monoclonal antibody was purchased from Calbiochem (EMD Biosciences, California, USA); anti-actin polyclonal, anti-Bax and anti-Mcl-1 monoclonal antibodies from Santa Cruz (Santa Cruz Biotechnology, California, USA); anti-tubulin monoclonal ...
SUMO modification regulates the transcriptional activity of FLASH.
Tsilibary Effie C., In PLoS ONE, 2008
... rabbit anti-cleaved caspase-3 (9664), rabbit anti-poly (ADP-ribose) polymerase, PARP (9542), rabbit anti-cleaved PARP (5625), rabbit anti-MCL-1 (5453) (Cell Signaling, Beverly, MA); mouse monoclonal ...
G3139, an anti-Bcl-2 antisense oligomer that binds heparin-binding growth factors and collagen I, alters in vitro endothelial cell growth and tubular morphogenesis
Koch Troels et al., In Nucleic Acids Research, 2008
... The anti-poly(ADP-ribosyl)polymerase (PARP) monoclonal, anti-pro-caspase-3 monoclonal, anti-Bcl-xL polyclonal, anti-Mcl-1 polyclonal antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
The BCL-2 protein family: opposing activities that mediate cell death
Kaufmann Scott H. et al., In The Journal of Cell Biology, 2007
... Antibodies to the following antigens were purchased from the indicated suppliers: Hsp60, Bim, Bad, and Mcl-1 from Cell Signaling Technology; cytochrome ...
Bcl2 inhibits abasic site repair by down-regulating APE1 endonuclease activity
Deng Xingming et al., In Molecular Cancer, 2007
... Mcl-1, pERK, ERK1/2, Bim and tubulin antibodies as well as Mcl1 siRNA were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
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Papers on Mcl-1
Induced Apoptosis Investigation in Wild-Type and FLT3-ITD Acute Myeloid Leukemia Cells by Nanochannel Electroporation and Single Cell qRT-PCR.
Lee et al., Columbus, United States. In Mol Ther, Feb 2016
NEP, together with single cell qRT-PCR, led to an observation showing nearly 20 folds more Mcl-1 siRNA than MCL1 mRNA were required to induce cell death for both cell lines and patient blasts, i.e. ~8800 siRNAs for ~500±50 mRNAs in ITD cells and ~6000 siRNAs for ~300±50 mRNAs in WT cells.
Combination of galectin inhibitor GCS-100 and BH3 mimetics eliminates both p53 wild type and p53 null AML cells.
Andreeff et al., Houston, United States. In Biochim Biophys Acta, Jan 2016
The agent reduced MCL-1 expression suggesting that GCS-100 could be more effective when combined with a BH3 mimetic.
Upregulation of the MCL-1S protein variant following dihydroartemisinin treatment induces apoptosis in cholangiocarcinoma cells.
Li et al., Chongqing, China. In Oncol Lett, Dec 2015
DHA treatment increased the ratio of MCL-1S/MCL-1L protein, thus inducing apoptosis in cholangiocarcinoma cells.
[Mechanisms of Apoptosis Induced by FTY720 in Multiple Myeloma Cell Line U266].
Liu et al., Shenyang, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, Dec 2015
U266 cells were treated with 0, 5, 10 and 20 µmol/L of FTY720 for 24 hours, the expressions of MCL-1, survivin, BCL-2, BID, BAX, BAK, P-ERK were tested by Western blot.
Activation-Induced Cytidine Deaminase Expression in Human B Cell Precursors Is Essential for Central B Cell Tolerance.
Meffre et al., New Haven, United States. In Immunity, Dec 2015
However, most AID(+) immature B cells lacked anti-apoptotic MCL-1 and were deleted by apoptosis.
An interconnected hierarchical model of cell death regulation by the BCL-2 family.
Cheng et al., Kettering, United States. In Nat Cell Biol, Oct 2015
BCL-2, BCL-XL and MCL-1 inhibit both modes of BAX-BAK activation by sequestering activator BH3s and 'BH3-exposed' monomers of BAX-BAK, respectively.
Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members.
Opferman, Memphis, United States. In Febs J, Sep 2015
To escape such death inducing signals, cancer cells often select for upregulation of anti-apoptotic BCL-2 family members including BCL-2, BCL-XL , BFL-1, BCL-W and MCL-1.
The two faces of miR-29.
Pulakat et al., Columbia, United States. In J Cardiovasc Med (hagerstown), Jul 2015
Additionally, miR-29-mediated suppression of myeloid cell leukemia 1 (MCL-1), an important prosurvival protein, underlies Marfan's syndrome, abdominal aortic aneurysm, and diabetes mellitus-associated cardiomyocyte disorganization.
Thyroid hormone and anti-apoptosis in tumor cells.
Davis et al., Taipei, Taiwan. In Oncotarget, Jul 2015
In a nanoparticulate formulation limiting its action to αvβ3, tetrac modulates integrin-dependent effects on gene expression in human cancer cell lines that include increased expression of a panel of pro-apoptotic genes and decreased transcription of defensive anti-apoptotic XIAP and MCL1 genes.
Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways.
Murray et al., Memphis, United States. In Immunity, 2015
Development of the granulocyte subset requires MCL-1-mediated control of the intrinsic mitochondrial death pathway.
Differential Effects of β-Blockers, Angiotensin II Receptor Blockers, and a Novel AT2R Agonist NP-6A4 on Stress Response of Nutrient-Starved Cardiovascular Cells.
Pulakat et al., Columbia, United States. In Plos One, 2014
Myeloid Cell Leukemia 1 (MCL-1) is a protein critical for cardiovascular cell survival and implicated in cell adhesion.
MYC-mediated synthetic lethality for treatment of hematological malignancies.
Huang et al., Wuhan, China. In Curr Cancer Drug Targets, 2014
Many small molecule inhibitors (SMIs) have been proven to induce MYC-SL by targeting AUK-B, Brd4, CDK1, CHK1, MCL-1, the mTOR/4E-BP1/eIF4E pathway, and PIM1/2.
DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis.
Hengartner et al., Zürich, Switzerland. In Nat Cell Biol, 2014
Microtubule-targeting chemotherapeutics induce apoptosis in cancer cells by promoting the phosphorylation and degradation of the anti-apoptotic BCL-2 family member MCL1.
Targeting BCL2-Proteins for the Treatment of Solid Tumours.
Vogler, Leicester, United Kingdom. In Adv Med, 2013
To this end, several strategies have been developed to inhibit BCL2, BCL-XL, BCL-w, and MCL1.
A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells.
Lieberman et al., Boston, United States. In Cancer Cell, 2013
Proteasome addiction in basal-like TNBCs was mediated by NOXA and linked to MCL-1 dependence.
Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling.
Yokoyama et al., Kōchi, Japan. In Arterioscler Thromb Vasc Biol, 2012
Thrombomodulin upregulates extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling to protect endothelial cells from calcineurin inhibitor-induced toxicity.
N-α-acetyltransferase 10 protein inhibits apoptosis through RelA/p65-regulated MCL1 expression.
Shou et al., Beijing, China. In Carcinogenesis, 2012
study revealed a novel mechanism controlling MCL1 expression, in which Naa10p and RelA/p65 synergistically interact with MCL1 promoter region and promote MCL1 transcription
Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration.
Opferman et al., Memphis, United States. In Nat Cell Biol, 2012
report that different forms of MCL-1 reside in distinct mitochondrial locations and exhibit separable functions
Critical role for antiapoptotic Bcl-xL and Mcl-1 in human macrophage survival and cellular IAP1/2 (cIAP1/2) in resistance to HIV-Vpr-induced apoptosis.
Kumar et al., Ottawa, Canada. In J Biol Chem, 2012
resistance to Vpr-induced apoptosis is specifically mediated by cIAP1/2 genes independent of Bcl-xL and Mcl-1, which play a key role in maintaining cell viability.
MYC directs transcription of MCL1 and eIF4E genes to control sensitivity of gastric cancer cells toward HDAC inhibitors.
Schneider et al., München, Germany. In Cell Cycle, 2012
MCL1 expression levels inversely correlate with the responsiveness of gastric cancer cells toward HDACi.
More papers using Mcl-1 antibodies
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
Idziorek T et al., In Oncogene, 2006
... The mouse MCL-1 antibody was purchased from Rockland (Philadelphia, PA, USA), and ...
Mitochondrial membrane permeabilization in cell death.
Blanke Steven R., In PLoS Pathogens, 2006
... Santa Cruz Biotechnology (Santa Cruz, CA); g) mouse monoclonal anti-Bcl2 and rabbit polyclonal anti-Bcl-xL and anti-Mcl1, all from Santa Cruz Biotechnology; h) rabbit polyclonal against ...
Interleukin-22: A novel T- and NK-cell derived cytokine that regulates the biology of tissue cells
Gao Bin et al., In International Journal of Biological Sciences, 2005
... Anti-Mcl-1 antibody (Abcam, Cambridge, MA), anti-VMP1 antibody ...
A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies.
Jin Dong-Yan, In PLoS ONE, 2005
... Rabbit polyclonal anti-XIAP, anti-caspase-8, anti-Mcl-1, and anti-PARP antibodies and mouse monoclonal anti-survivin antibody were purchased from Cell Signaling Technology, Inc ...
Maintenance of the CD40-related immunodeficient response in hyper-IgM B cells immortalized with a LMP1-regulated mini-EBV.
Khan Wasif N., In PLoS ONE, 2004
... Mouse anti-Bcl-2 mAb, anti-Bcl-xL rabbit polyclonal anti-Mcl-1 rabbit polyclonal antisera were obtained from Ancell, LabVision and Chemicon respectively ...
JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD
Ellis L M et al., In British Journal of Cancer, 2003
... St Louis, MO, USA), polyclonal rabbit anti-DFF45 (BD Biosciences, San Diego, CA, USA), monoclonal mouse anti-MCL-1 (22; Santa Cruz Biotechnology), fluorescein isothiocyanate (FITC)-conjugated goat ...
Some precautions in using chelators to buffer metals in biological solutions
Shirihai Orian S., In PLoS ONE, 2003
... MCL-1 rabbit polyclonal antibody was purchased from Abcam (Cambridge, MA) or from ...
Determining significant fold differences in gene expression analysis
Koup Richard A, In PLoS Pathogens, 2000
... Antibodies to Bfl-1 and Mcl-1 were supplied by Cell Signaling Technologies ...
Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA
Wang HongYang et al., In Molecular Cancer, 1995
... Purified anti-Mcl-1 antibody was from Biolegend.
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