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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Melanin-concentrating hormone receptor 2

MCHR2, MCH2R, melanin-concentrating hormone receptor 2, hMCH-2R
Top mentioned proteins: dynamin 2, Neuropeptide, ACID, HAD, CAN
Papers on MCHR2
Molecular cloning, expression, and signaling pathway of four melanin-concentrating hormone receptors from Xenopus tropicalis.
New
Saito et al., Hiroshima, Japan. In Gen Comp Endocrinol, Mar 2015
It acts via two G-protein-coupled receptors, MCH receptor 1 (MCHR1) and MCHR2.
Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass Index in Psychiatric Patients and In Population-Based Subjects with Present or Past Atypical Depression.
Eap et al., Lausanne, Switzerland. In Plos One, 2014
Melanin-concentrating hormone receptor 2 (MCHR2) is a central receptor involved in energy homeostasis.
Shared genetic aetiology of puberty timing between sexes and with health-related outcomes.
Perry et al., Cambridge, United States. In Nat Commun, 2014
However, some loci show sex-divergent effects, including directionally opposite effects between sexes at the SIM1/MCHR2 locus (Pheterogeneity=1.6 × 10(-12)).
Expression of melanin-concentrating hormone receptor 2 protects against diet-induced obesity in male mice.
Maratos-Flier et al., Boston, United States. In Endocrinology, 2014
Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide that is a ligand for two subtypes of MCH receptors, MCHR1 and MCHR2.
Melanin-concentrating hormone control of sleep-wake behavior.
Review
Lagos et al., Montevideo, Uruguay. In Sleep Med Rev, 2013
The biological function of MCH is mediated by two G-protein-coupled receptors known as MCHR1 and MCHR2, although the latter is expressed only in carnivores, primates and man.
Characterization of ciliary targeting sequence of rat melanin-concentrating hormone receptor 1.
Saito et al., Hiroshima, Japan. In Gen Comp Endocrinol, 2013
Melanin-concentrating hormone (MCH) is the natural peptide ligand for MCHR1 and MCHR2, which belong to the G protein-coupled receptor (GPCR) superfamily.
Regulated Control of Melanin-Concentrating Hormone Receptor 1 through Posttranslational Modifications.
Review
Kobayashi et al., Hiroshima, Japan. In Front Endocrinol (lausanne), 2012
It activates two G-protein-coupled receptors, MCHR1 and MCHR2, of which MCHR1 is the primary regulator of food intake and energy homeostasis in rodents.
Identification of mRNAs coding for mammalian-type melanin-concentrating hormone and its receptors in the scalloped hammerhead shark Sphyrna lewini.
Takahashi et al., Sagamihara, Japan. In Gen Comp Endocrinol, 2012
MCH receptor genes mch-r1 and mch-r2 were expressed in the S. lewini hypothalamus, but were not found in the skin.
A preliminary investigation of the role of melanin-concentrating hormone (MCH) and its receptors in appetite regulation of winter flounder (Pseudopleuronectes americanus).
Volkoff et al., St. John's, Canada. In Mol Cell Endocrinol, 2012
In order to better understand the role of melanin-concentrating hormone (MCH) in the regulation of appetite in fish, the mRNAs of two forms of MCH, prepro-MCH and MCH2, and two forms of MCH receptors, MCH-R1 and MCH-R2, were isolated from winter flounder (Pseudopleuronectes americanus).
Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2.
GeneRIF
Li et al., San Francisco, United States. In Bioorg Med Chem Lett, 2012
Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2
Signalling pathway of goldfish melanin-concentrating hormone receptors 1 and 2.
Saito et al., Hiroshima, Japan. In Regul Pept, 2011
Melanin-concentrating hormone (MCH) is the natural ligand for the MCH-1 receptor (MCHR1) and MCH-2 receptor (MCHR2).
Recent updates on the melanin-concentrating hormone (MCH) and its receptor system: lessons from MCH1R antagonists.
Review
Civelli et al., Irvine, United States. In J Mol Neurosci, 2011
MCH interacts with two G-protein-coupled receptors, MCH1R and MCH2R, but only MCH1R is expressed in rodents.
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
Impact
Murray et al., Cambridge, United Kingdom. In Nat Genet, 2010
The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG).
Melanin-concentrating hormone receptor 2 affects 3T3-L1 preadipocyte differentiation.
GeneRIF
Song et al., Chongqing, China. In Mol Cell Endocrinol, 2009
MCHR2 positively mediates the regulation of melanin-concentrating hormone during preadipocyte differentiation and is involved in energy balance regulation without affecting preadipocyte proliferation.
Establishment of CHO cell line expressing human MCHR2 gene and research of its molecular characteristics.
GeneRIF
Song et al., Chongqing, China. In Indian J Exp Biol, 2009
construction of the CHO cell line and the research of MCHR2 molecular characteristics have established a good experimental basis for the further research about the function of MCHR2 gene
The role of melanin-concentrating hormone in energy homeostasis and mood disorders.
Review
Khawaja et al., Princeton, United States. In J Mol Neurosci, 2009
The melanin-concentrating hormone (MCH) is a cyclic peptide exerting its actions through two G-protein-coupled receptors, MCHR1 and MCHR2.
The melanin-concentrating hormone system and its physiological functions.
Review
Nagasaki et al., Hiroshima, Japan. In Results Probl Cell Differ, 2007
MCH binds to and activates two G protein-coupled receptors, MCH1R and MCH2R.
Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity.
GeneRIF
Meyre et al., Lille, France. In J Clin Endocrinol Metab, 2007
MCHR2 is not a major contributor to polygenic obesity
Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations.
GeneRIF
Fanelli et al., Reggio nell'Emilia, Italy. In Proteins, 2004
results of molecular simulations of MCHR2 in the free and hormone-bound forms provide suggestions on the amino acids responsible for the transfer of the structural changes from the agonist binding site to the G-protein coupling domains
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