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Kinesin family member 2C

The protein encoded by this gene is a member of kinesin-like protein family. Proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Aurora, CAN, Bub1, OUT, ATPase
Papers using MCAK antibodies
K-loop insertion restores microtubule depolymerizing activity of a “neckless” MCAK mutant
Wordeman Linda et al., In The Journal of Cell Biology, 1995
... MCAK cDNA fragment (from pOPRSVICAT-GFP-MCAK; Maney et al., 1998) into the pTRE2 vector (CLONTECH Laboratories, Inc.) digested with ...
Papers on MCAK
NuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity.
Liou et al., Singapore, Singapore. In Sci Rep, Dec 2015
In this study, we identify the microtubule depolymeriser, mitotic centromere-associated kinesin (MCAK), as a novel binding partner of NuSAP.
Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach.
Salomon et al., Indianapolis, United States. In Mol Psychiatry, Nov 2015
Finally, we tested the top increased and decreased biomarkers from the discovery for suicidal ideation (CADM1, CLIP4, DTNA, KIF2C), prioritization with CFG for prior evidence (SAT1, SKA2, SLC4A4), and validation for behavior in suicide completers (IL6, MBP, JUN, KLHDC3) steps in a completely independent test cohort of psychiatric participants for prediction of suicidal ideation (n=108), and in a future follow-up cohort of psychiatric participants (n=157) for prediction of psychiatric hospitalizations due to suicidality.
KLP-7 acts through the Ndc80 complex to limit pole number in C. elegans oocyte meiotic spindle assembly.
Bowerman et al., Eugene, United States. In J Cell Biol, Oct 2015
We show that KLP-7, the single mitotic centromere-associated kinesin (MCAK)/kinesin-13 in Caenorhabditis elegans, is required for bipolar oocyte meiotic spindle assembly.
Microtubule-associated proteins control the kinetics of microtubule nucleation.
Brouhard et al., Montréal, Canada. In Nat Cell Biol, Jul 2015
Catastrophe factors (MCAK and EB1) inhibited nucleation, whereas a polymerase (XMAP215) and an anti-catastrophe factor (TPX2) promoted nucleation.
Spatiotemporal dynamics of Aurora B-PLK1-MCAK signaling axis orchestrates kinetochore bi-orientation and faithful chromosome segregation.
Yao et al., Hefei, China. In Sci Rep, 2014
The microtubule depolymerase mitotic centromere-associated kinesin (MCAK) is a key regulator for an accurate kinetochore-microtubule attachment.
The KLP-7 Residue S546 Is a Putative Aurora Kinase Site Required for Microtubule Regulation at the Centrosome in C. elegans.
Srayko et al., Edmonton, Canada. In Plos One, 2014
Vertebrate MCAK locates to chromatin, kinetochores, spindle poles, microtubule tips, and the cytoplasm, implying that the regulation of kinesin-13 activity and subcellular targeting is complex.
Exploitation of the Androgen Receptor to Overcome Taxane Resistance in Advanced Prostate Cancer.
Kyprianou et al., Lexington, United States. In Adv Cancer Res, 2014
Cabazitaxel treatment also leads to downregulation of the microtubule-depolymerizing mitotic kinesins, MCAK, and HSET, preventing their ability to depolymerize microtubules and thus enhancing sensitivity to taxane treatment.
Kif2C minimal functional domain has unusual nucleotide binding properties that are adapted to microtubule depolymerization.
Wang et al., Shanghai, China. In J Biol Chem, 2012
a mechanism in which, in the first step, the specificity of ATP-bound Kif2C for soluble tubulin causes it to stabilize a curved conformation of tubulin heterodimers at the ends of microtubules.
MCAK activity at microtubule tips regulates spindle microtubule length to promote robust kinetochore attachment.
Wordeman et al., Seattle, United States. In J Cell Biol, 2012
study identifed and defined a mitotic function specific to the microtubule tip-associated population of MCAK: negative regulation of microtubule length within the assembling bipolar spindle.
Mitosis phase enrichment with identification of mitotic centromere-associated kinesin as a therapeutic target in castration-resistant prostate cancer.
Zhang et al., Houston, United States. In Plos One, 2011
The mitotic centromere-associated kinesin (MCAK) was identified as a novel mitosis-phase target in prostate cancer that was overexpressed in multiple castration-resistant prostate cancer gene-expression datasets.
Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target.
Yuan et al., Frankfurt am Main, Germany. In Oncotarget, 2011
The kinesin-13 family is critical in the regulation of microtubule dynamics and the best characterized member of the family, the mitotic centromere-associated kinesin (MCAK), has recently been attracting enormous attention.
A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases.
Medema et al., Utrecht, Netherlands. In Curr Biol, 2011
Results uncover a novel role for Aurora A/B kinases in regulating spindle MT dynamics through Kif18b-MCAK and suggest that the Kif18b-MCAK complex constitutes the major MT plus-end depolymerizing activity in mitotic cells.
The bidirectional depolymerizer MCAK generates force by disassembling both microtubule ends.
Ishiwata et al., Tokyo, Japan. In Nat Cell Biol, 2011
Results provide a simple model for the generation of driving force and the regulation of chromosome segregation by the activity of MCAK at both kinetochores and spindle poles through a 'side-sliding, end-catching' mechanism.
Multi-talented MCAK: Microtubule depolymerizer with a strong grip.
Diez, In Nat Cell Biol, 2011
MCAK, a member of the kinesin-13 motor protein family, is now shown to grip microtubules on its own and harness the forces of microtubule disassembly.
Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis.
Higgins et al., Boston, United States. In Science, 2010
A nonbinding Survivin-D70A/D71A mutant does not support centromeric CPC concentration, and both Haspin depletion and Survivin-D70A/D71A mutation diminish centromere localization of the kinesin MCAK and the mitotic checkpoint response to taxol.
Determination of microtubule dynamic instability in living cells.
Jordan et al., Santa Barbara, United States. In Methods Cell Biol, 2009
Microtubule-associated proteins (MAPs) such as MAP2 and tau (Bunker et al., 2004; Dhamodharan and Wadsworth, 1995) and microtubule-interacting proteins such as stathmin, the kinesin MCAK, and EB1 (Cassimeris, 1999; Moore and Wordeman, 2004; Ringhoff and Cassimeris, 2009; Rusan et al., 2001) as well as numerous clinically approved or experimental anti-mitotic drugs including the taxanes, vinca alkaloids, and colchicine-like compounds modulate microtubule dynamic in cells (Jordan, 2002; Jordan and Kamath, 2007).
Predominant regulators of tubulin monomer-polymer partitioning and their implication for cell polarization.
Gullberg et al., Umeå, Sweden. In Cell Mol Life Sci, 2009
Four unrelated conserved proteins, XMAP215/Dis1/TOGp, MCAK, MAP4 and Op18/stathmin, have all been implicated as predominant regulators of tubulin monomer-polymer partitioning in animal cells.
An EB1-binding motif acts as a microtubule tip localization signal.
Steinmetz et al., Switzerland. In Cell, 2009
By using live cell experiments and in vitro reconstitution assays, we demonstrate that a short polypeptide motif, Ser-x-Ile-Pro (SxIP), is used by numerous +TIPs, including the tumor suppressor APC, the transmembrane protein STIM1, and the kinesin MCAK, for localization to microtubule tips in an EB1-dependent manner.
The mechanism, function and regulation of depolymerizing kinesins during mitosis.
Wordeman et al., Seattle, United States. In Trends Cell Biol, 2004
Recently, much work has been done to elucidate the structure and mechanism of depolymerizing kinesins, particularly those of the mammalian kinesin mitotic centromere-associated kinesin (MCAK).
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