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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Melanocortin 1 receptor

MC1R, melanocortin receptor, melanocortin-1 receptor
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on MC1R
Defining MC1R regulation in human melanocytes by its agonist α-melanocortin and antagonists agouti signaling protein and β-defensin 3.
Abdel-Malek et al., Cincinnati, United States. In J Invest Dermatol, 2012
results identify HBD3 as an antagonist of the MC1R that is expressed in human melanocytes and shed new light on the regulation of MC1R expression and activity by its agonist and antagonists.
Germline melanocortin-1-receptor genotype is associated with severity of cutaneous phenotype in congenital melanocytic nevi: a role for MC1R in human fetal development.
Healy et al., London, United Kingdom. In J Invest Dermatol, 2012
Germline melanocortin-1-receptor genotype is associated with severity of cutaneous phenotype in congenital melanocytic nevi and MC1R has a role in human fetal development
Melanocortin 1 receptor regulates melanoma cell migration by controlling syndecan-2 expression.
Oh et al., Seoul, South Korea. In J Biol Chem, 2012
MC1R regulates melanoma cell migration via inhibition of syndecan-2 expression.
Alpha-melanocyte-stimulating hormone suppresses oxidative stress through a p53-mediated signaling pathway in human melanocytes.
Abdel-Malek et al., Cincinnati, United States. In Mol Cancer Res, 2012
Results show that p53 is an important target of the downstream melanocortin 1 receptor (MC1R) signaling that reduces oxidative stress and possibly malignant transformation of melanocytes.
Phenotypic and histologic characteristics of cutaneous melanoma in patients with melanocortin-1 receptor polymorphisms.
Ribas et al., Madrid, Spain. In Actas Dermosifiliogr, 2012
At least 1 of the following was present in 58% of cutaneous melanoma patients: V60L, V92M, I155T, R163Q and especially R160W & D294H. Carriers had a history of sunburn.Carriers of R160W also had melanomas associated with melanocytic nevi.
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