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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Melanocortin 1 receptor

MC1R, melanocortin receptor, melanocortin-1 receptor
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAIR, CAN, HAD, MC4R, ACID
Papers on MC1R
A Review of the Association Between Parkinson Disease and Malignant Melanoma.
Schram et al., Minneapolis, United States. In Dermatol Surg, Feb 2016
Other possible connections that have been explored include pigmentation genes in neural-derived cells, pesticides, MC1R polymorphisms, and abnormal cellular autophagy.
Agouti signalling protein (ASIP) gene: molecular cloning, sequence characterisation and tissue distribution in domestic goose.
He et al., Shanghai, China. In Br Poult Sci, Feb 2016
UNASSIGNED: 1. Agouti signalling protein (ASIP) is an endogenous antagonist of melanocortin-1 receptor (MC1R) and is involved in the regulation of pigmentation in mammals.
Evolution around the Red Sea: Systematics and biogeography of the agamid genus Pseudotrapelus (Squamata: Agamidae) from North Africa and Arabia.
Carranza et al., Tel Aviv-Yafo, Israel. In Mol Phylogenet Evol, Feb 2016
We included all known species and subspecies, and sequenced them for mitochondrial (16S, ND4 and tRNAs) and nuclear (MC1R, c-mos) markers.
Role of Hypothalamic VGF in Energy Balance and Metabolic Adaption to Environmental Enrichment in Mice.
Cao et al., Columbus, United States. In Endocrinology, Feb 2016
Moreover, hypothalamic VGF expression was regulated by leptin, melanocortin receptor agonist, and food deprivation mostly paralleled to BDNF expression.
The genetic basis of color-related local adaptation in a ring-like colonization around the Mediterranean.
Roulin et al., Uppsala, Sweden. In Evolution, Jan 2016
Rufous coloration appears to be linked to a recently evolved nonsynonymous-derived variant of the melanocortin 1 receptor (MC1R) gene, which according to quantitative genetic analyses evolved under local adaptation during or following the colonization of Central Europe.
Effect of interactions of polymorphisms in the Melanocortin-4 receptor gene with dietary factors on the risk of obesity and Type 2 diabetes: a systematic review.
Mirmiran et al., Tehrān, Iran. In Diabet Med, Jan 2016
METHODS: A systematic literature search was conducted in the PubMed, Scopus and Google Scholar databases, with a combination of the following keywords: Diet*, nutr*, melanocortin receptor, melanocortin 4 receptor and MC4R.
Germline gene polymorphisms predisposing domestic mammals to carcinogenesis.
Switonski et al., Freising, Germany. In Vet Comp Oncol, Dec 2015
This review summarizes the present understanding of germline gene polymorphisms, including BRCA1, BRCA2, MC1R, KIT, NRAS and RAD51, associated with predisposition to melanoma, mammary cancer, osteosarcoma and histiocytic sarcoma in dogs, cats, pigs and horses.
Inhibitory Effect of the Melanocortin Receptor Agonist Melanotan-II (MTII) on Feeding Depends on Dietary Fat Content and not Obesity in Rats on Free-Choice Diets.
la Fleur et al., Amsterdam, Netherlands. In Front Behav Neurosci, 2014
The aim of this study was to determine the influence of diet composition on feeding responses to a melanocortin receptor agonist, using free-choice diets that differ in food components.
Sex Differences in Kappa Opioid Receptor Function and Their Potential Impact on Addiction.
Mavrikaki et al., Belmont, United States. In Front Neurosci, 2014
We will highlight evidence that the function of DYN-KOR systems is influenced in a sex-dependent manner by: polymorphisms in the prodynorphin (pDYN) gene, genetic linkage with the melanocortin-1 receptor (MC1R), heterodimerization of KORs and mu opioid receptors (MORs), and gonadal hormones.
The associations between Parkinson's disease and cancer: the plot thickens.
Chen et al., Boston, United States. In Transl Neurodegener, 2014
This positive association has been supported by several common genetic mutations in SNCA, PARK2, PARK8, ATM, p53, PTEN, and MC1R resulting in cellular changes such as mitochondrial dysfunction, aberrant protein aggregation, and cell cycle dysregulation.
Glutamate mediates the function of melanocortin receptor 4 on Sim1 neurons in body weight regulation.
Tong et al., Houston, United States. In Cell Metab, 2014
The melanocortin receptor 4 (MC4R) is a well-established mediator of body weight homeostasis.
Mrap2: an accessory protein linked to obesity.
Williams et al., Dallas, United States. In Cell Metab, 2013
Companion studies published in Science (Asai et al., 2013; Sebag et al., 2013) establish a role for melanocortin receptor accessory protein 2 (Mrap2) in regulating melanocortin receptor activity and in the development of obesity in zebrafish, rodents, and humans.
Developmental control of the melanocortin-4 receptor by MRAP2 proteins in zebrafish.
Cone et al., Nashville, United States. In Science, 2013
MC4R interacts with melanocortin receptor accessory protein 2 (MRAP2) in vitro, but its functions in vivo are unknown.
Direct migration of follicular melanocyte stem cells to the epidermis after wounding or UVB irradiation is dependent on Mc1r signaling.
Ito et al., New York City, United States. In Nat Med, 2013
We also found that McSCs migrate to the epidermis in a melanocortin 1 receptor (Mc1r)-dependent manner and differentiate into functional epidermal melanocytes, providing a pigmented protective barrier against ultraviolet irradiation over the damaged skin.
An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background.
Fisher et al., United States. In Nature, 2012
Genetically, this phenotype is frequently the product of inactivating polymorphisms in the melanocortin 1 receptor (MC1R) gene.
Defining MC1R regulation in human melanocytes by its agonist α-melanocortin and antagonists agouti signaling protein and β-defensin 3.
Abdel-Malek et al., Cincinnati, United States. In J Invest Dermatol, 2012
results identify HBD3 as an antagonist of the MC1R that is expressed in human melanocytes and shed new light on the regulation of MC1R expression and activity by its agonist and antagonists.
Germline melanocortin-1-receptor genotype is associated with severity of cutaneous phenotype in congenital melanocytic nevi: a role for MC1R in human fetal development.
Healy et al., London, United Kingdom. In J Invest Dermatol, 2012
Germline melanocortin-1-receptor genotype is associated with severity of cutaneous phenotype in congenital melanocytic nevi and MC1R has a role in human fetal development
Melanocortin 1 receptor regulates melanoma cell migration by controlling syndecan-2 expression.
Oh et al., Seoul, South Korea. In J Biol Chem, 2012
MC1R regulates melanoma cell migration via inhibition of syndecan-2 expression.
Alpha-melanocyte-stimulating hormone suppresses oxidative stress through a p53-mediated signaling pathway in human melanocytes.
Abdel-Malek et al., Cincinnati, United States. In Mol Cancer Res, 2012
Results show that p53 is an important target of the downstream melanocortin 1 receptor (MC1R) signaling that reduces oxidative stress and possibly malignant transformation of melanocytes.
Phenotypic and histologic characteristics of cutaneous melanoma in patients with melanocortin-1 receptor polymorphisms.
Ribas et al., Madrid, Spain. In Actas Dermosifiliogr, 2012
At least 1 of the following was present in 58% of cutaneous melanoma patients: V60L, V92M, I155T, R163Q and especially R160W & D294H. Carriers had a history of sunburn.Carriers of R160W also had melanomas associated with melanocytic nevi.
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