Germline gene polymorphisms predisposing domestic mammals to carcinogenesis.
Freising, Germany. In Vet Comp Oncol, Dec 2015
This review summarizes the present understanding of germline gene polymorphisms, including BRCA1, BRCA2, MC1R, KIT, NRAS and RAD51, associated with predisposition to melanoma, mammary cancer, osteosarcoma and histiocytic sarcoma in dogs, cats, pigs and horses.
The associations between Parkinson's disease and cancer: the plot thickens.
Boston, United States. In Transl Neurodegener, 2014
This positive association has been supported by several common genetic mutations in SNCA, PARK2, PARK8, ATM, p53, PTEN, and MC1R resulting in cellular changes such as mitochondrial dysfunction, aberrant protein aggregation, and cell cycle dysregulation.
Mrap2: an accessory protein linked to obesity.
Dallas, United States. In Cell Metab, 2013
Companion studies published in Science (Asai et al., 2013; Sebag et al., 2013) establish a role for melanocortin receptor accessory protein 2 (Mrap2) in regulating melanocortin receptor activity and in the development of obesity in zebrafish, rodents, and humans.