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Methyl-CpG binding domain protein 3

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on MBD3
Pulmonary surfactant protein A protects lung epithelium from cytotoxicity of human β-defensin 3.
Kuroki et al., Sapporo, Japan. In J Biol Chem, 2012
SP-A protects lung epithelium from tissue injury caused by BD3
Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells.
Fazzio et al., Worcester, United States. In Cell, 2012
Study finds that Mbd3 and Brg1 antagonistically regulate a common set of genes by regulating promoter nucleosome occupancy; furthermore, both Mbd3 and Brg1 play key roles in the biology of 5-hydroxymethylcytosine.
c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex.
Behrens et al., London, United Kingdom. In Nature, 2011
the transactivation domain of c-Jun recruits Mbd3/NuRD to AP-1 target genes to mediate gene repression, and this repression is relieved by JNK-mediated c-Jun N-terminal phosphorylation
Chronic colitis induces expression of β-defensins in murine intestinal epithelial cells.
Hammarström et al., Umeå, Sweden. In Clin Exp Immunol, 2011
Mouse beta-defensin 3 was strongly up-regulated in colonic epithelium of 15 (but not 5) week-old IL-2(-/-) mice and in dextran-sulfate-induced chronic (but not acute) colitis, but not in IL-2(+/-) 15-week-old mice.
Antifungal activity of recombinant mouse beta-defensin 3.
Li et al., Chengdu, China. In Lett Appl Microbiol, 2010
Epithelial and mucosal tissues expressed bd3 and recombinant bd3 exhibits antifungal activity.
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