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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

MYC-associated zinc finger protein

MAZ, SAF-1, Myc-associated zinc finger protein
Top mentioned proteins: c-Myc, SP1, CAN, V1a, HAD
Papers on MAZ
Heavy metals produce toxicity, oxidative stress and apoptosis in the marine teleost fish SAF-1 cell line.
New
Cuesta et al., Murcia, Spain. In Chemosphere, Feb 2016
In this study, fibroblast SAF-1 cells from the marine gilthead seabream (Sparus aurata L.) were exposed for 24 h to the heavy metals Cd, Hg, MeHg (Methylmercury), As or Pb and the resulting cytotoxicity was assessed.
Anteriorly located zonular fibres as a tool for fine regulation in accommodation.
New
Lütjen-Drecoll et al., Erlangen, Germany. In Ophthalmic Physiol Opt, Jan 2016
These most anterior zonules (MAZ) showed attachments either to the anterior or posterior tines or they inserted directly onto the surface of the lens.
Nucleic Acid Targeted Therapy: G4 Oligonucleotides Downregulate HRAS in Bladder Cancer Cells through a Decoy Mechanism.
New
Xodo et al., Udine, Italy. In Acs Med Chem Lett, Jan 2016
In a previous study we have demonstrated that two neighboring G-quadruplexes, hras-1 and hras-2, located immediately upstream of the major transcription start site of HRAS, bind MAZ, a nuclear factor that activates transcription (Cogoi, S.; et al.
KRAS promoter oligonucleotide with decoy activity dimerizes into a unique topology consisting of two G-quadruplex units.
New
Plavec et al., Ljubljana, Slovenia. In Nucleic Acids Res, Jan 2016
Previous studies showed that a 32-nt oligonucleotide (32R-3n) mimicking the KRAS NHE can reduce gene transcription by sequestering MAZ, a crucial transcription factor.
Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes.
New
Wiemels et al., San Francisco, United States. In Epigenetics, Jan 2016
The top folate-sensitive genes defined by their associated CpG sites were enriched for numerous transcription factors by Gene Set Enrichment Analysis, including those implicated in cancer development (e.g., MYC-associated zinc finger protein).
Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region.
New
Moore et al., Cork, Ireland. In Hum Mol Genet, Oct 2015
In the human and mouse the SPRY3 promoter contains an AG-rich repeat and we found co-expression, and promoter binding and/or regulation of SPRY3 expression by transcription factors MAZ, EGR1, ZNF263 and PAX6.
The histone code reader SPIN1 controls RET signaling in liposarcoma.
New
Schüle et al., Freiburg, Germany. In Oncotarget, Apr 2015
Combining signaling pathway, genome-wide chromatin binding, and transcriptome analyses, we found that SPIN1 directly enhances expression of GDNF, an activator of the RET signaling pathway, in cooperation with the transcription factor MAZ. Accordingly, knockdown of SPIN1 or MAZ results in reduced levels of GDNF and activated RET explaining diminished liposarcoma cell proliferation and survival.
In vitro characterization of 6-Coumarin loaded solid lipid nanoparticles and their uptake by immunocompetent fish cells.
New
Esteban et al., Bari, Italy. In Colloids Surf B Biointerfaces, Apr 2015
The primary aim of the present work was to evaluate the in vitro uptake of 6-Coumarin (6COUM) loaded solid lipid nanoparticles (SLN) by two gilthead seabream (Sparus aurata L.) cell types: an established cell line (SAF-1 cells) and the primary cultures of head-kidney (HK)-the main haemopoietic organ in fish, equivalent to mammalian bone marrow-leucocytes.
MiR-449a exerts tumor-suppressive functions in human glioblastoma by targeting Myc-associated zinc-finger protein.
New
Liu et al., Shenyang, China. In Mol Oncol, Mar 2015
Myc-associated zinc-finger protein (MAZ) was identified as a direct target of miR-449a, mediating these tumor-suppressive effects, demonstrated by Western blot assay and luciferase assays.
Induction of Ras by SAF-1/MAZ through a feed-forward loop promotes angiogenesis in breast cancer.
New
Ray et al., United States. In Cancer Med, Feb 2015
We have previously shown that vascular endothelial growth factor (VEGF) expression in triple negative breast cancer cells is regulated, at least in part, by SAF-1 (serum amyloid A activating factor 1) transcription factor.
Differential expression of CYB5A in Chinese and European pig breeds due to genetic variations in the promoter region.
New
Fang et al., Beijing, China. In Anim Genet, Feb 2015
Quantitative PCR data from liver tissues demonstrated that haplotype B individuals had higher CYB5A expression than did those with haplotype A. This was confirmed by in vitro cell transfection assays, in which haplotype B individuals had higher reporter activity than did those with haplotype A. In silico analysis predicted that Myc-associated zinc-finger protein (MAZ) is a potential transcription factor at position 165901767.
A Transcriptomic Study of Maternal Thyroid Adaptation to Pregnancy in Rats.
Fu et al., Guangzhou, China. In Int J Mol Sci, 2014
In addition, by examining of the promoter regions of up-regulated genes, we identified MAZ (MYC-associated zinc finger protein) and TFCP2 (transcription factor CP2) as two causal transcription factors.
Control of VEGF expression in triple-negative breast carcinoma cells by suppression of SAF-1 transcription factor activity.
GeneRIF
Ray et al., Columbia, United States. In Mol Cancer Res, 2011
these findings reveal that SAF-1 is a hitherto unrecognized participant in inducing VEGF expression in triple-negative breast cancer cells, an aggressive form of breast cancer that currently lacks effective treatment options.
The KRAS promoter responds to Myc-associated zinc finger and poly(ADP-ribose) polymerase 1 proteins, which recognize a critical quadruplex-forming GA-element.
GeneRIF
Xodo et al., Udine, Italy. In J Biol Chem, 2010
These data support a transcription mechanism for murine KRAS that involves MAZ, PARP-1 and duplex-quadruplex conformational changes in the promoter G-rich nuclease hypersensitive element.
SAF-3, a novel splice variant of the SAF-1/MAZ/Pur-1 family, is expressed during inflammation.
GeneRIF
Ray et al., Columbia, United States. In Febs J, 2009
Existence of multiple promoters regulation MAZ, which is expressed during inflammation.
Gastrin activates paracrine networks leading to induction of PAI-2 via MAZ and ASC-1.
GeneRIF
Varro et al., Liverpool, United Kingdom. In Am J Physiol Gastrointest Liver Physiol, 2009
Gastrin activates paracrine networks leading to induction of PAI-2 via MAZ and ASC-1.
Transcriptional synergy mediated by SAF-1 and AP-1: critical role of N-terminal polyalanine and two zinc finger domains of SAF-1.
GeneRIF
Ray et al., Columbia, United States. In J Biol Chem, 2009
The SAF-1.c-Fos.c-Jun ternary complex efficiently promotes transcription from both SAF-1 and AP-1 sites of human MMP-1 promoter.
Transcriptional regulation by zinc-finger proteins Sp1 and MAZ involves interactions with the same cis-elements.
Review
Yokoyama et al., Tsukuba, Japan. In Int J Mol Med, 2003
Various transcription factors, such as Sp1 and MAZ, include C2H2-type zinc-finger motifs and are able to bind to GC-rich cis-elements that are distributed in the promoter regions of numerous mammalian genes.
Why is the adrenal adrenergic?
Review
Wong, Belmont, United States. In Endocr Pathol, 2002
Other factors may include several transcriptional activators of the PNMT gene: Egr-1, AP2, Sp1, and MAZ.
Cholinergic and peptidergic regulation of phenylethanolamine N-methyltransferase gene expression.
Review
Tai et al., Belmont, United States. In Ann N Y Acad Sci, 2002
A slight decrease in Sp1 expression may also occur, whereas MAZ and glucocorticoid receptor expression remains unaltered.
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