The histone code reader SPIN1 controls RET signaling in liposarcoma.
Freiburg, Germany. In Oncotarget, Apr 2015
Combining signaling pathway, genome-wide chromatin binding, and transcriptome analyses, we found that SPIN1 directly enhances expression of GDNF, an activator of the RET signaling pathway, in cooperation with the transcription factor MAZ. Accordingly, knockdown of SPIN1 or MAZ results in reduced levels of GDNF and activated RET explaining diminished liposarcoma cell proliferation and survival.
Differential expression of CYB5A in Chinese and European pig breeds due to genetic variations in the promoter region.
Beijing, China. In Anim Genet, Feb 2015
Quantitative PCR data from liver tissues demonstrated that haplotype B individuals had higher CYB5A expression than did those with haplotype A. This was confirmed by in vitro cell transfection assays, in which haplotype B individuals had higher reporter activity than did those with haplotype A. In silico analysis predicted that Myc-associated zinc-finger protein (MAZ) is a potential transcription factor at position 165901767.
Why is the adrenal adrenergic?
Belmont, United States. In Endocr Pathol, 2002
Other factors may include several transcriptional activators of the PNMT gene: Egr-1, AP2, Sp1, and MAZ.