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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Matrix metallopeptidase 1

matrix metalloproteinase, MMP-1, Matrix Metalloproteinase 1
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: MMP-9, MMP-2, V1a, CAN, HAD
Papers using matrix metalloproteinase antibodies
Association of hepatocyte growth factor promoter polymorphism with severity of interstitial lung disease in Japanese patients with systemic sclerosis
Silver Richard M. et al., In Pulmonary Medicine, 2010
... Rosiglitazone and GW 9662 were purchased from Cayman Chemical, Ann Arbor, Mich, USA; EnzoLytePlus 520 MMP-1 Assay Kit was obtained from AnaSpec (San Jose, Calif, USA); ...
Osteoarthritis or osteoarthrosis: the definition of inflammation becomes a semantic issue in the genomic era of molecular medicine
Loeser Richard F et al., In Arthritis Research & Therapy, 2001
... RayBio Human Inflammation Antibody Array III and Matrix Metalloproteinase Antibody Array were from Raybiotech (Norcross, GA, USA) ...
Papers on matrix metalloproteinase
High level of αB-crystallin contributes to the progression of osteosarcoma.
Cheng et al., Nanchang, China. In Oncotarget, Feb 2016
In this study, we showed that Cryab expression was elevated in OS tissues and cell lines, and down-regulation of Cryab in MG-63 and U-2OS cells led to a decline in the cells' aggressiveness, and reduced secretion of matrix metalloproteinase-9 (MMP-9) in vitro, and lower metastasis potential in vivo.
The glycocalyx and its significance in human medicine.
Cancel et al., New York City, United States. In J Intern Med, Feb 2016
By contrast, the glycocalyx on cancer cells is generally robust, promoting integrin clustering and growth factor signalling, and mechanotransduction of interstitial flow shear stress that is elevated in tumours to upregulate matrix metalloproteinase release which enhances cell motility and metastasis.
Matrix Metalloproteinase 2 as a Potential Mediator of Vascular Smooth Muscle Cell Migration and Chronic Vascular Remodeling in Hypertension.
Castro et al., Ribeirão Preto, Brazil. In J Vasc Res, Feb 2016
UNASSIGNED: For vascular remodeling in hypertension, it is essential that vascular smooth muscle cells (VSMCs) reshape in order to proliferate and migrate.
Halofuginone Treatment reduces interleukin-17A and ameliorates features of chronic lung allograft dysfunction in a mouse orthotopic lung transplant model.
Keshavjee et al., Toronto, Canada. In J Heart Lung Transplant, Jan 2016
Halofuginone treatment also decreased IL-17A and IL-22 transcripts at Day 14, transforming growth factor-β1 and matrix metalloproteinase-2 transcripts at Days 14 and 28.
Niclosamide suppresses migration of hepatocellular carcinoma cells and downregulates matrix metalloproteinase-9 expression.
Ishige et al., Yotsukaidō, Japan. In Oncol Lett, Dec 2015
Expression levels of cyclin D1 and matrix metalloproteinase 9 (MMP9) were analyzed by performing revers transcription-quantitative polymerase chain reaction.
Association of Matrix Metalloproteinase-9 Gene -1562C/T Polymorphism with Essential Hypertension: A Systematic Review and Meta-Analysis Article.
Zhang et al., Shanghai, China. In Iran J Public Health, Nov 2015
BACKGROUND: Matrix metalloproteinase-9 (MMP-9) gene -1562C/T polymorphism could regulate its expression level and thus affected people's predisposition to essential hypertension.
The Role of Matrix Metalloproteinase-9 (MMP-9) as a Prognostic Factor in Epithelial and Lymphatic Neoplasia.
- et al., In Chirurgia (bucur), Nov 2015
Matrix metalloproteinase 9 is a zinc-dependent extracellular matrix remodeling endopeptidase directly involved in the local invasion mechanisms and in metastasis.
Pathophysiology, presentation, prognosis, and management of intracranial arterial dolichoectasia.
Amarenco et al., Versailles, France. In Lancet Neurol, Aug 2015
The pathophysiology is largely unknown, but IADE can be viewed as a common final pathway of arterial wall response or damage in the tunica media due to various mechanisms, such as matrix metalloproteinase dysfunction or muscle cell or elastic fibre injury.
Theoretical insights into the functioning of metallopeptidases and their synthetic analogues.
Prabhakar et al., Coral Gables, United States. In Acc Chem Res, Mar 2015
The Zn(N3) [Zn(His, His, His)] core of matrix metalloproteinase was better than the Zn(N2O) [Zn(His, His, Glu)] core of IDE for peptide hydrolysis.
Inhibition by a retinoic acid receptor γ agonist of extracellular matrix remodeling mediated by human Tenon fibroblasts.
Sonoda et al., Ube, Japan. In Mol Vis, 2014
TGF-β1-induced MMP-1 and MMP-3 release, FAK phosphorylation, and fibronectin and type I collagen production in HTFs were also attenuated by R667.
Is there new hope for therapeutic matrix metalloproteinase inhibition?
Libert et al., Gent, Belgium. In Nat Rev Drug Discov, 2014
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that form a family of 24 members in mammals.
Meta-analysis of association of the matrix metalloproteinase 2 (-735 C/T) polymorphism with cancer risk.
Park et al., Seoul, South Korea. In Int J Clin Exp Med, 2014
The association between matrix metalloproteinase 2 (MMP2) gene polymorphisms and cancer risk has been investigated in many published studies; however, the currently available results are inconclusive.
Oestradiol Treatment Counteracts the Effect of Fructose-Rich Diet on Matrix Metalloproteinase 9 Expression and NFκB Activation.
Stankovic et al., Belgrade, Serbia. In Folia Biol (praha), 2014
UNASSIGNED: Fructose-rich diet induces metabolic changes similar to those observed in metabolic syndrome.
Pathogenic Neisseria meningitidis utilizes CD147 for vascular colonization.
Bourdoulous et al., Paris, France. In Nat Med, 2014
Here, we report that the immunoglobulin superfamily member CD147 (also called extracellular matrix metalloproteinase inducer (EMMPRIN) or Basigin) is a critical host receptor for the meningococcal pilus components PilE and PilV.
A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity.
Overall et al., Vancouver, Canada. In Nat Med, 2014
Interferon-α (IFN-α) is essential for antiviral immunity, but in the absence of matrix metalloproteinase-12 (MMP-12) or IκBα (encoded by NFKBIA) we show that IFN-α is retained in the cytosol of virus-infected cells and is not secreted.
Matrix metalloprotease-1a promotes tumorigenesis and metastasis.
Kuliopulos et al., Boston, United States. In J Biol Chem, 2012
data demonstrate that cancer cell-derived Mmp1a acts as a robust functional homologue of MMP1 by conferring protumorigenic and metastatic behavior to cells.
Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling.
Zhou et al., Guangzhou, China. In Free Radic Biol Med, 2012
High MMP1 is associated with migration and invasion of tongue squamous cell carcinoma.
Invasive markers identified by gene expression profiling in pancreatic cancer.
Conlon et al., Tallaght, Ireland. In Pancreatology, 2012
We have identified three potential invasive markers, uPA, MMP-1 and IL1-R1, whose gene expression may differentiate PDAC from other pancreatic neoplasms.
[Morphological features of placenta and expression of collagen-6, MMP-1 and TIMP-1 in placental membranes of women with premature rupture of membranes].
Kvetnoĭ et al., In Arkh Patol, 2012
Morphological features of placenta and expression of collagen-6, MMP-1 and TIMP-1 in placental membranes of women with premature rupture of membranes
The association between individual SNPs or haplotypes of matrix metalloproteinase 1 and gastric cancer susceptibility, progression and prognosis.
Xu et al., Shenyang, China. In Plos One, 2011
The study presents seven single nucleotide polymorphisms of MMP-1, which might not be useful as significant markers to predict gastric cancer susceptibility, progression or prognosis, at least in the Han population in northern China.
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