Matrix Metalloproteinase 20
Inactivation of C4orf26 in toothless placental mammals.
Riverside, United States. In Mol Phylogenet Evol, Dec 2015
UNASSIGNED: Previous studies have reported inactivated copies of six enamel-related genes (AMBN, AMEL, AMTN, ENAM, KLK4, MMP20) and one dentin-related gene (DSPP) in one or more toothless vertebrates and/or vertebrates with enamelless teeth, thereby providing evidence that these genes are enamel or tooth-specific with respect to their critical functions that are maintained by natural selection.
Analysis of the association between polymorphisms in MMP2, MMP3, MMP9, MMP20, TIMP1, and TIMP2 genes with white spot lesions and early childhood caries.
Nova Friburgo, Brazil. In Int J Paediatr Dent, Oct 2015
AIM: This study aimed to evaluate the association between polymorphisms in MMP2, MMP3, MMP9, MMP20, TIMP1, and TIMP2 with white spot lesions (WSL) and early childhood caries (ECC).
Cell cycle control, DNA damage repair, and apoptosis-related pathways control pre-ameloblasts differentiation during tooth development.
Chengdu, China. In Bmc Genomics, 2014
Moreover, coexpression network analysis uncovered two highly conserved sub-networks contributing to differentiation, containing transcription regulators (RUNX2, ETV1 and ETV5), solute carrier family members (SLC15A1 and SLC7A11), enamel matrix protein (MMP20), and a polymodal excitatory ion channel (TRPA1).
Dental enamel development: proteinases and their enamel matrix substrates.
Cambridge, United States. In Isrn Dent, 2012
This review focuses on recent discoveries and delves in detail about what is known about each of the proteins (amelogenin, ameloblastin, and enamelin) and proteinases (matrix metalloproteinase-20 and kallikrein-related peptidase-4) that are secreted into the enamel matrix.
Amelogenesis imperfecta: an introduction.
In Br Dent J, 2012
Amelogenesis imperfecta (AI) is an inherited disorder that is associated with mutations in five genes (AMEL; ENAM; MMP20; KLK4 and FAM83H) with a wide range of clinical presentations (phenotypes).
Defining a new candidate gene for amelogenesis imperfecta: from molecular genetics to biochemistry.
Santiago, Chile. In Biochem Genet, 2011
These disorders are considered clinically and genetically heterogeneous in etiology, involving a variety of genes, such as AMELX, ENAM, DLX3, FAM83H, MMP-20, KLK4, and WDR72.
Genetics and genomics of human ageing.
Stanford, United States. In Philos Trans R Soc Lond B Biol Sci, 2011
The genomic convergence approach has been used to implicate the gene MMP20 in human kidney ageing.