Epigenetic modifications of splicing factor genes in myelodysplastic syndromes and acute myeloid leukemia.
Australia. In Cancer Sci, 2014
Here, we examined promoter DNA hypermethylation of nine splicing factors, SF3B1, SRSF2, U2AF1, ZRSR2, SF3A1, HNRNPR, MATR3, ZFR, and YBX3 in 10 leukemic cell lines and 94 MDS or AML patient samples from the Australasian Leukemia and Lymphoma Group Tissue Bank.
Laminopathies and lamin-associated signaling pathways.
Bologna, Italy. In J Cell Biochem, 2011
Lamin-binding proteins implicated in laminopathies include lamin B2, nuclear envelope proteins such as emerin, MAN1, LBR, and nesprins, the nuclear matrix protein matrin 3, the lamina-associated polypeptide, LAP2alpha and the transcriptional regulator FHL1.
Matrin 3 binds and stabilizes mRNA.
Tel Aviv-Yafo, Israel. In Plos One, 2010
Data suggest that the cellular level of MATR3, known to be highly regulated, modulates the stability of a group of gene transcripts.
[Functional arrangement of genomic DNA and structure of nuclear matrix].
Toyama, Japan. In Yakugaku Zasshi, 2000
Since the nucleotide sequence of P130 cDNA cloned by us was closely similar to that of matrin 3 cDNA cloned, except for two incorrect nucleotides within the matrin 3 coding region, and since the functions of matrin 3 were unknown, P130, referred to as P130/Mat3, was functionally characterized.