GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Atonal homolog 7
Math5, Atoh7, ath5
This intronless gene encodes a member of the basic helix-loop-helix family of transcription factors, with similarity to Drosophila atonal gene that controls photoreceptor development. Studies in mice suggest that this gene plays a central role in retinal ganglion cell and optic nerve formation. Mutations in this gene are associated with nonsyndromic congenital retinal nonattachment. [provided by RefSeq, Dec 2011] (from
NCBI)
Sponsored links
Top mentioned proteins:
FATE, Six1, HAD, Six3, Ngn2
Papers using
Math5
antibodies
Influences on neural lineage and mode of division in the zebrafish retina in vivo
Supplier
In The Journal of Cell Biology, 1996
... Baier, University of California, San Francisco, San Francisco, CA), or were ath5:GFP transgenic ( ...
Papers on
Math5
Molecular Characterization of FZD4, LRP5, and TSPAN12 in Familial Exudative Vitreoretinopathy.
New
Seoul, South Korea. In Invest Ophthalmol Vis Sci, Aug 2015
In patients with no mutation detected, sequencing analyses for ZNF408, a novel gene potentially related to FEVR, and two other genes related to retinal development, LGR4 and ATOH7, were performed.
Genetic Variants Associated With Different Risks for High Tension Glaucoma and Normal Tension Glaucoma in a Chinese Population.
New
Shanghai, China. In Invest Ophthalmol Vis Sci, Apr 2015
A total of 13 previously reported single nucleotide polymorphisms (SNPs) located at four gene regions (TMCO1, CDKN2B-AS1, ATOH7, and SIX1/SIX6) was genotyped.
Involvement of genetic variants associated with primary open-angle glaucoma in pathogenic mechanisms and family history of glaucoma.
New
Japan. In Am J Ophthalmol, Mar 2015
METHODS: Japanese patients with NTG (n = 213) and HTG (n = 212) and 191 control subjects were genotyped for 5 non-IOP-related genetic variants predisposing to POAG near the SRBD1, ELOVL5, CDKN2B/CDKN2B-AS1, SIX1/SIX6, and ATOH7 genes.
Genetic association of SNPs near ATOH7, CARD10, CDKN2B, CDC7 and SIX1/SIX6 with the endophenotypes of primary open angle glaucoma in Indian population.
Chennai, India. In Plos One, 2014
The current study attempts to explore the association of variations near/in genes like ATOH7, SIX1/SIX6 complex, CDKN2B, CARD10, and CDC7 with POAG and its QTs including vertical cup to disc ratio (VCDR), central corneal thickness (CCT), intra ocular pressure (IOP), and axial length (AL).
Developmental remodeling of relay cells in the dorsal lateral geniculate nucleus in the absence of retinal input.
San Diego, United States. In Neural Dev, 2014
To accomplish this we utilized the math5 null (math5 (-/-) ) mouse, a mutant lacking retinal ganglion cells and central projections.
Advances in glaucoma genetics.
Review
Japan. In Prog Brain Res, 2014
Recent genome-wide association studies revealed a large number of susceptibility gene variants associated with both POAG (e.g., CDKN2BAS, CAV1/CAV2, and ATOH7) and PACG (e.g., PLEKHA7 and COL11A1 PCMTD1-ST18).
Transdifferentiation of periodontal ligament-derived stem cells into retinal ganglion-like cells and its microRNA signature.
Hong Kong, Hong Kong. In Sci Rep, 2014
The differentiated PDLSCs demonstrated the characteristics of functional neurons as they expressed neuronal and retinal ganglion cell markers (ATOH7, POU4F2, β-III tubulin, MAP2, TAU, NEUROD1 and SIX3), formed synapses and showed glutamate-induced calcium responses as well as spontaneous electrical activities.
An Updated Review on the Genetics of Primary Open Angle Glaucoma.
Review
Riyadh, Saudi Arabia. In Int J Mol Sci, 2014
Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) at different loci including CAV1/CAV2, TMCO1, CDKN2B-AS1, CDC7-TGFBR3, SIX1/SIX6, GAS7 and ATOH7 to be associated with POAG and its related quantitative traits (endophenotypes).
DNA copy number variants of known glaucoma genes in relation to primary open-angle glaucoma.
Durham, United States. In Invest Ophthalmol Vis Sci, 2014
We further limited our investigation to CNVs in known POAG-related genes, including CDKN2B-AS1, TMCO1, SIX1/SIX6, CAV1/CAV2, the LRP12-ZFPM2 region, GAS7, ATOH7, FNDC3B, CYP1B1, MYOC, OPTN, WDR36, SRBD1, TBK1, and GALC.
Transcriptome of Atoh7 retinal progenitor cells identifies new Atoh7-dependent regulatory genes for retinal ganglion cell formation.
Houston, United States. In Dev Neurobiol, 2014
The bHLH transcription factor ATOH7 (Math5) is essential for establishing retinal ganglion cell (RGC) fate.
The genetic architecture of microphthalmia, anophthalmia and coloboma.
Review
Edinburgh, United Kingdom. In Eur J Med Genet, 2014
This review will focus on MAC phenotypes that are associated with mutation of the genes SOX2, OTX2, PAX6, STRA6, ALDH1A3, RARB, VSX2, RAX, FOXE3, BMP4, BMP7, GDF3, GDF6, ABCB6, ATOH7, C12orf57, TENM3 (ODZ3), and VAX1.
Differential responsiveness of distinct retinal domains to Atoh7.
Heidelberg, Germany. In Mech Dev, 2014
For their development, Atoh7, a basic Helix Loop Helix (bHLH) transcription factor is crucial.
Duplication of TBK1 Stimulates Autophagy in iPSC-derived Retinal Cells from a Patient with Normal Tension Glaucoma.
Iowa City, United States. In J Stem Cell Res Ther, 2014
Differentiation to retinal ganglion-like cells was demonstrated via rt-PCR targeted against TUJ1, MAP2, THY1, NF200, ATOH7 and BRN3B and immunohistochemistry targeted against NF200 and ATOH7.
Association of known common genetic variants with primary open angle, primary angle closure, and pseudoexfoliation glaucoma in Pakistani cohorts.
Nijmegen, Netherlands. In Mol Vis, 2013
METHODS: Six variants in CDKN2B-AS1 (rs4977756), CDKN2B (rs1063192), ATOH7 (rs1900004), CAV1 (rs4236601), TMCO1 (rs4656461), and SIX1 (rs10483727) were genotyped using TaqMan assays.
Pushing the envelope of retinal ganglion cell genesis: context dependent function of Math5 (Atoh7).
GeneRIF
Ann Arbor, United States. In Dev Biol, 2012
Results suggest that Math5 is not sufficient to stimulate retinal ganglion cell (RGC)fate.
Math5 defines the ganglion cell competence state in a subpopulation of retinal progenitor cells exiting the cell cycle.
GeneRIF
Ann Arbor, United States. In Dev Biol, 2012
new insights into Math5 function, ganglion cell development, and the mechanism of retinal fate determination were provided.
The deletion of Math5 disrupts retinal blood vessel and glial development in mice.
GeneRIF
Baltimore, United States. In Exp Eye Res, 2012
The present data demonstrates that the loss of ganglion cells in the Math5(-/-) mice is associated with a lack of retinal vascular development.
Next generation sequencing identifies mutations in Atonal homolog 7 (ATOH7) in families with global eye developmental defects.
GeneRIF
Leeds, United Kingdom. In Hum Mol Genet, 2012
findings document Mendelian mutations within ATOH7 and imply a role for this molecule in the development of structures at the front as well as the back of the eye; study provides further insights into the function of ATOH7, especially its importance in retinal vascular development and hyaloid regression
Interactive effects of ATOH7 and RFTN1 in association with adult-onset primary open-angle glaucoma.
GeneRIF
Shantou, China. In Invest Ophthalmol Vis Sci, 2012
combination of ATOH7 and RFTN1 SNPs increased risk to POAG, indicating their diversified effects in the complex genetics of glaucoma.
bHLH genes and retinal cell fate specification.
Review
Birmingham, United States. In Mol Neurobiol, 2005
Photoreceptor genesis appears to employ two transcriptional pathways: ngn2-->neuroD-->raxL and ath5-->neuroD-->raxL. ngn2 and ath5 function in progenitors, which can potentially develop into different cell types.
