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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Atonal homolog 1

Math1, ATH1, Atoh1
Encodes transcription factor involved in photomorphogenesis. Regulates gibberellin biosynthesis. Activated by AGAMOUS in a cal-1, ap1-1 background. Expressed at low levels in developing stamens. Increased levels of ATH1 severely delay flowering in the C24 accession. Most remarkably, ectopically expressed ATH1 hardly had an effect on flowering time in the Col-0 and Ler accessions. ATH1 physically interacts with STM, BP and KNAT6 and enhances the shoot apical meristem defect of some of these genes suggesting a role in SAM maintenance. Nuclear localization is dependent upon interaction with STM. (from NCBI)
Top mentioned proteins: CAN, ACID, HAIR, SET, CHIP
Papers on Math1
Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration.
New
Impact
Hanash et al., New York City, United States. In Nature, Jan 2016
ATOH1-deficient organoid culture demonstrated that IL-22 induced epithelial regeneration independently of the Paneth cell niche.
Bile acids induce Delta-like 1 expression via Cdx2-dependent pathway in the development of Barrett's esophagus.
New
Kinoshita et al., Izumo, Japan. In Lab Invest, Dec 2015
We determined the expression levels of Dll1 and intracellular signaling molecules related to Notch signaling ((Notch1, Hairy/enhancer of split 1 (Hes1), and Atonal homolog 1 (ATOH1)) in human esophageal squamous and Barrett's epithelium samples.
Origin of a Non-Clarke's Column Division of the Dorsal Spinocerebellar Tract and the Role of Caudal Proprioceptive Neurons in Motor Function.
New
Lai et al., Dallas, United States. In Cell Rep, Dec 2015
The progenitor domain defined by the basic-helix-loop-helix (bHLH) transcription factor, ATOH1, has been implicated in forming these cerebellar-projecting neurons; however, their precise contribution to proprioceptive tracts and motor behavior is unknown.
The regulation of gene expression in hair cells.
Review
New
Masuda et al., San Diego, United States. In Hear Res, Nov 2015
The transcription factor ATOH1 is well known for its ability to transform nonsensory cells of the developing inner ear into hair cells.
Repression of Lateral Organ Boundary Genes by PENNYWISE and POUND-FOOLISH Is Essential for Meristem Maintenance and Flowering in Arabidopsis.
New
Pautot et al., Saskatoon, Canada. In Plant Physiol, Nov 2015
We show here that pny pnf apices misexpress lateral organ boundary genes BLADE-ON-PETIOLE1/2 (BOP1/2) and KNOTTED-LIKE FROM ARABIDOPSIS THALIANA6 (KNAT6) together with ARABIDOPSIS THALIANA HOMEOBOX GENE1 (ATH1).
Role of the planar cell polarity pathway in regulating ectopic hair cell-like cells induced by Math1 and testosterone treatment.
New
Chi et al., Shanghai, China. In Brain Res, Aug 2015
Retroviral-mediated introduction of the Math1 transcription factor leads to the transdifferentiation of some mature supporting cells into hair cells.
Nonviral Reprogramming of Human Wharton's Jelly Cells Reveals Differences Between ATOH1 Homologues.
New
Detamore et al., Tokushima, Japan. In Tissue Eng Part A, Jun 2015
To evaluate potential functional differences between homologues, human and mouse ATOH1 (HATH1 and MATH-1, respectively) were nonvirally delivered to human Wharton's jelly cells (hWJCs) for the first time.
Mucus mediated protection against acute colitis in adiponectin deficient mice.
Fayad et al., Columbia, United States. In J Inflamm (lond), 2014
Protein expression levels were quantified by Western blot for MATH1, Hes1, MUC2 and MUC4.
Diversity in global gene expression and morphology across a watercress (Nasturtium officinale R. Br.) germplasm collection: first steps to breeding.
Taylor et al., Andover, United Kingdom. In Hortic Res, 2014
Variation in global gene expression was investigated using an Affymetrix Arabidopsis ATH1 microarray gene chip, using the commercial control (C), an accession selected for dwarf phenotype with a high AO potential (dwarfAO, called 'Boldrewood') and one with high AO potential alone.
ATOH1 Can Regulate the Tumorigenicity of Gastric Cancer Cells by Inducing the Differentiation of Cancer Stem Cells.
Oh et al., Pusan, South Korea. In Plos One, 2014
Here we show that ATOH1 can induce the differentiation of gastric cancer stem cells (GCSCs).
Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity.
Impact
Shivdasani et al., Boston, United States. In Nature, 2014
On this chromatin background, ATOH1, a secretory-specific transcription factor, controls lateral inhibition through delta-like notch ligand genes and also drives the expression of numerous secretory lineage genes.
Atoh1 expression and function during auditory hair cell regeneration in post-hatch chickens.
GeneRIF
Stone et al., Seattle, United States. In Hear Res, 2012
Atoh1 is broadly upregulated in supporting cells after damage, but a substantial proportion of supporting cells with Atoh1 activation fail to acquire hair cell features, in part due to gamma secretase-dependent activities.
Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1).
GeneRIF
Romagnolo et al., Paris, France. In Proc Natl Acad Sci U S A, 2012
Math1-deficient crypts counteract the absence of Paneth cell-derived Wnts and prevent base columnar cell-stem cell exhaustion.
Atoh1, an essential transcription factor in neurogenesis and intestinal and inner ear development: function, regulation, and context dependency.
GeneRIF
Dabdoub et al., San Diego, United States. In J Assoc Res Otolaryngol, 2012
involved in differentiation of neurons, secretory cells in the gut, and mechanoreceptors including auditory hair cells [review]
A novel Atoh1 "self-terminating" mouse model reveals the necessity of proper Atoh1 level and duration for hair cell differentiation and viability.
GeneRIF
Fritzsch et al., Iowa City, United States. In Plos One, 2011
Data show that Atoh1 is crucial for hair cell mechanotransduction development, viability, and maintenance.
Expression of Neurog1 instead of Atoh1 can partially rescue organ of Corti cell survival.
GeneRIF
Fritzsch et al., Iowa City, United States. In Plos One, 2011
Atoh1(KINeurog1) can provide some degree of functional support for survival of organ of Corti cells.
Regulation of gene expression in the intestinal epithelium.
Review
Breault et al., Boston, United States. In Prog Mol Biol Transl Sci, 2009
In this chapter, we review the major signaling pathways underlying regulation of gene expression within the intestinal epithelium, based primarily on data from mouse models, as well as specific morphogens and transcription factor families that have a major role in regulating intestinal gene expression, including the Hedgehog family, Forkhead Box (FOX) factors, Homeobox (HOX) genes, ParaHox genes, GATA transcription factors, canonical Wnt/β-catenin signaling, EPH/Ephrins, Sox9, BMP signaling, PTEN/PI3K, LKB1, K-RAS, Notch pathway, HNF, and MATH1.
Repair of the vestibular system via adenovector delivery of Atoh1: a potential treatment for balance disorders.
Review
Staecker et al., Baltimore, United States. In Adv Otorhinolaryngol, 2008
Delivery of the atonal homolog, atoh1, has been demonstrated to induce recovery of auditory and vestibular hair cells using a variety of delivery methods and model systems.
Just say no to ATOH: how HIC1 methylation might predispose medulloblastoma to lineage addiction.
Review
Watkins et al., Baltimore, United States. In Cancer Res, 2008
Recently, we showed that HIC1 is a direct transcriptional repressor of ATOH1, a proneural transcription factor required for normal cerebellar development, as well as for medulloblastoma cell viability.
Stem cells and molecular strategies to restore hearing.
Review
Fritzsch et al., Omaha, United States. In Panminerva Med, 2008
In either of these strategies, hair cell specific genes known to be essential for hair cell differentiation or maintenance such as ATOH1, POU4F3, GFI1, and miRNA-183 will be utilized with the hope of completely restoring hearing to all patients with hearing loss.
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