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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Methionine adenosyltransferase II, alpha

The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011] (from NCBI)
Top mentioned proteins: AdoMet, CAN, HAD, V1a, Histone
Papers on MAT2A
Methionine adenosyltransferase α2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells.
Lu et al., Los Angeles, United States. In Oncotarget, Dec 2015
Methionine adenosyltransferase 2A (MAT2A) encodes for MATα2, the catalytic subunit of the MATII isoenzyme that synthesizes S-adenosylmethionine (SAMe).
Induction of methionine adenosyltransferase 2A in tamoxifen-resistant breast cancer cells.
Kang et al., Seoul, South Korea. In Oncotarget, Oct 2015
Here, we found that the basal expression level of methionine adenosyltransferase 2A (MAT2A), a critical enzyme for the biosynthesis of S-adenosylmethionine, was up-regulated in TAMR-MCF-7 cells compared with control MCF-7 cells.
Prenatal alcohol exposure alters methyl metabolism and programs serotonin transporter and glucocorticoid receptor expression in brain.
Devlin et al., Vancouver, Canada. In Am J Physiol Regul Integr Comp Physiol, Sep 2015
We assessed whether PAE affects one-carbon metabolism (including Mtr, Mat2a, Mthfr, and Cbs mRNA) and programming of HPA function genes (Nr3c1, Nr3c2, and Slc6a4) in offspring from ethanol-fed (E), pair-fed (PF), and ad libitum-fed control (C) dams.
Role of methionine adenosyltransferase α2 and β phosphorylation and stabilization in human hepatic stellate cell trans-differentiation.
Park et al., Los Angeles, United States. In J Cell Physiol, May 2015
We have previously shown that two MAT genes, MAT2A and MAT2B (encoding MATα2 and MATβ proteins respectively), are required for HSC activation and loss of MAT2A transcriptional control favors its up-regulation during trans-differentiation.
PARTICLE, a Triplex-Forming Long ncRNA, Regulates Locus-Specific Methylation in Response to Low-Dose Irradiation.
Anastasov et al., In Cell Rep, May 2015
Exposure to low-dose irradiation causes transiently elevated expression of the long ncRNA PARTICLE (gene PARTICLE, promoter of MAT2A-antisense radiation-induced circulating lncRNA).
Characterizing and optimizing human anticancer drug targets based on topological properties in the context of biological pathways.
Li et al., Daqing, China. In J Biomed Inform, Apr 2015
Furthermore, the performance for mercaptopurine was significant: 6 known targets (ADSL, GMPR2, GMPR, HPRT1, AMPD3, AMPD2) were ranked in the top 15 and other four out of the top 15 (MAT2A, CDKN1A, AREG, JUN) have the potentialities to become new targets for cancer therapy.
MAT2A mutations predispose individuals to thoracic aortic aneurysms.
Milewicz et al., Houston, United States. In Am J Hum Genet, Feb 2015
A rare variant, c.1031A>C (p.Glu344Ala), was identified in MAT2A, which encodes methionine adenosyltransferase II alpha (MAT IIα).
2',6'-Dihalostyrylanilines, pyridines, and pyrimidines for the inhibition of the catalytic subunit of methionine S-adenosyltransferase-2.
Watt et al., Lexington, United States. In J Med Chem, 2014
Inhibition of the catalytic subunit of the heterodimeric methionine S-adenosyl transferase-2 (MAT2A) with fluorinated N,N-dialkylaminostilbenes (FIDAS agents) offers a potential avenue for the treatment of liver and colorectal cancers where upregulation of this enzyme occurs.
Structure and function study of the complex that synthesizes S-adenosylmethionine.
Rojas et al., Liverpool, United Kingdom. In Iucrj, 2014
In humans, there are three genes, mat1A, mat2A and mat2B, which encode MAT enzymes.
Markers of hepatic regeneration associated with surgical attenuation of congenital portosystemic shunts in dogs.
House et al., United Kingdom. In Vet J, 2014
There were significant increases in HGF (P = 0.050) and methionine adenosyltransferase 2 A (MAT2A; P = 0.002) mRNA expression following partial CPSS attenuation.
Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis.
Pascale et al., Sassari, Italy. In J Hepatol, 2013
Downregulation of liver-specific MAT1A gene, encoding S-adenosylmethionine (SAM) synthesizing isozymes MATI/III, and upregulation of widely expressed MAT2A, encoding MATII isozyme, known as MAT1A:MAT2A switch, occurs in hepatocellular carcinoma (HCC).
Metabolic aspects of epigenome: coupling of S-adenosylmethionine synthesis and gene regulation on chromatin by SAMIT module.
Katoh et al., Sendai, Japan. In Subcell Biochem, 2012
Three distinct forms of MAT (MATI, MATII and MATIII), encoded by two distinct genes (MAT1A and MAT2A), have been identified in mammals.
S-adenosylmethionine in liver health, injury, and cancer.
Mato et al., Los Angeles, United States. In Physiol Rev, 2012
In mammals, two genes, MAT1A that is largely expressed by normal liver and MAT2A that is expressed by all extrahepatic tissues, encode MAT.
Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression.
Pascale et al., Sassari, Italy. In Hepatology, 2012
we found for the first time a post-transcriptional regulation of MAT1A and MAT2A by AUF1 and HuR in hepatocellular carcinoma.
Transcriptional regulation of methionine adenosyltransferase 2A by peroxisome proliferator-activated receptors in rat hepatic stellate cells.
Tomasi et al., Los Angeles, United States. In Hepatology, 2012
PPARgamma as a negative regulator of MAT2A in quiescent hepatic stellate cells. A switch from quiescence to activation abolishes this control and allows PPARbeta to up-regulate MAT2A transcription.
Insulin-like growth factor 1 activates methionine adenosyltransferase 2A transcription by multiple pathways in human colon cancer cells.
Lu et al., Los Angeles, United States. In Biochem J, 2011
Insulin-like growth factor 1 (IGF1) activates methionine adenosyltransferase 2A MAT2A) transcription by both known and novel pathways in colon cancer cells.
Hypoxia induces genomic DNA demethylation through the activation of HIF-1α and transcriptional upregulation of MAT2A in hepatoma cells.
Liu et al., Wuhan, China. In Mol Cancer Ther, 2011
hypoxia-induced MAT2A expression is HIF-1alpha dependent
Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein.
Igarashi et al., Sendai, Japan. In Mol Cell, 2011
Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein
S-Adenosylmethionine in cell growth, apoptosis and liver cancer.
Mato et al., Los Angeles, United States. In J Gastroenterol Hepatol, 2008
In mammals, two genes (MAT1A and MAT2A), encode for two homologous MAT catalytic subunits, while a third gene MAT2beta, encodes for the beta-subunit that regulates MAT2A-encoded isoenzyme.
Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer.
Mato et al., Los Angeles, United States. In Alcohol, 2005
Two genes (MAT1A and MAT2A) encode for the essential enzyme methionine adenosyltransferase (MAT), which catalyzes the biosynthesis of S-adenosylmethionine (SAMe), the principal methyl donor and, in the liver, a precursor of glutathione.
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