FXYD6 is a new biomarker of cholangiocarcinoma.
Suzhou, China. In Oncol Lett, 2014
Members of the FXYD domain-containing ion transport regulator protein family, including FXYD3 and FXYD5, play an important role in the pathogenesis of numerous tumors.
Gene expression profiling of intrahepatic cholangiocarcinoma.
Bangkok, Thailand. In Asian Pac J Cancer Prev, 2012
For validation of the microarray results, 7 up-regulated genes (FXYD3, GPRC5A, CEACAM5, MUC13, EPCAM, TMC5, and EHF) and 3 down- regulated genes (CPS1, TAT, and ITIH1) were selected for confirmation using quantitative RT-PCR, resulting in 100% agreement.
[FXYD proteins: novel regulators of Na,K-ATPase].
Lausanne, Switzerland. In Med Sci (paris), 2006
Recent evidence suggests that 6 out of 7 FXYD proteins, FXYD1 (phospholemman), FXYD2 (gamma subunit of Na,K-ATPase), FXYD3 (Mat-8), FXYD4 (CHIF), FXYD5 (Ric) and FXYD7 associate with Na,K-ATPase and modulate its transport properties e.g. its Na+ and/or its K+ affinity in a distinct way.
FXYD proteins: new regulators of Na-K-ATPase.
Lausanne, Switzerland. In Am J Physiol Renal Physiol, 2006
Recent experimental evidence suggests that at least five of the seven members of this family, FXYD1 (phospholemman), FXYD2 (gamma-subunit of Na-K-ATPase), FXYD3 (Mat-8), FXYD4 (CHIF), and FXYD7, are auxiliary subunits of Na-K-ATPase and regulate Na-K-ATPase activity in a tissue- and isoform-specific way.
Function of FXYD proteins, regulators of Na, K-ATPase.
Lausanne, Switzerland. In J Bioenerg Biomembr, 2005
FXYD3 expressed in stomach, colon, and numerous tumors also modulates the transport properties of Na, K-ATPase but it has a lower specificity of association than other FXYD proteins and an unusual membrane topology.