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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Microtubule associated serine/threonine kinase 2

MAST205, MAST2, hMAST205
Top mentioned proteins: sAST, CD45, MAST, CAN, PTEN
Papers on MAST205
A Screen for Genomic Disorders of Infertility Identifies MAST2 Duplications Associated with Nonobstructive Azoospermia in Humans.
New
Hu et al., Nanjing, China. In Biol Reprod, Sep 2015
In our discovery sample we observed 3 case-specific duplications of the autosomal gene MAST2, and in a replication phase we found another 11 duplications in 1457 patients and 1 duplication in 1590 controls (P < 5 × 10(-5), combined data).
Deciphering the unconventional peptide binding to the PDZ domain of MAST2.
New
Wolff et al., Paris, France. In Biochem J, Aug 2015
Phosphatase and tensin homologue (PTEN) and microtubule-associated serine threonine kinase 2 (MAST2) are key negative regulators of survival pathways in neuronal cells.
MAST2 and NOTCH1 translocations in breast carcinoma and associated pre-invasive lesions.
West et al., Stanford, United States. In Hum Pathol, 2013
FISH break-apart assays were designed for NOTCH1 and MAST2 gene rearrangements.
MAST205 competes with cystic fibrosis transmembrane conductance regulator (CFTR)-associated ligand for binding to CFTR to regulate CFTR-mediated fluid transport.
Naren et al., Memphis, United States. In J Biol Chem, 2013
To better understand the regulation of CFTR processing, we conducted a genetic screen and identified MAST205 (a microtubule-associated serine/threonine kinase with a molecular mass of 205 kDa) as a new CFTR regulator.
Genome-wide landscapes of human local adaptation in Asia.
Xu et al., Shanghai, China. In Plos One, 2012
Notable examples, such as FOXQ1, MAST2, and CDH4, were found to play a role in hair follicle development and human cancer, signal transduction, and tumor repression, respectively.
A functional yeast survival screen of tumor-derived cDNA libraries designed to identify anti-apoptotic mammalian oncogenes.
Zörnig et al., Frankfurt am Main, Germany. In Plos One, 2012
PAICS, an enzyme required for de novo purine biosynthesis, the long non-coding RNA MALAT1 and the MAST2 kinase are overexpressed in certain tumor entities and capable of suppressing apoptosis in human cells.
Transcriptional regulation of human-specific SVAF₁ retrotransposons by cis-regulatory MAST2 sequences.
GeneRIF
Buzdin et al., Moscow, Russia. In Gene, 2012
The MAST2 sequence at the 5' end of SVA(F1) acts as a positive transcriptional regulator in human germ cells.
Interference with the PTEN-MAST2 interaction by a viral protein leads to cellular relocalization of PTEN.
Wolff et al., Paris, France. In Sci Signal, 2012
PTEN (phosphatase and tensin homolog deleted on chromosome 10) and MAST2 (microtubule-associated serine and threonine kinase 2) interact with each other through the PDZ domain of MAST2 (MAST2-PDZ) and the carboxyl-terminal (C-terminal) PDZ domain-binding site (PDZ-BS) of PTEN.
Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer.
Impact
GeneRIF
Chinnaiyan et al., Ann Arbor, United States. In Nat Med, 2011
Overexpression of MAST1 or MAST2 gene fusions has a proliferative effect both in vitro and in vivo in breast cancer cell lines.
High-throughput single-nucleotide polymorphism discovery and the search for candidate genes for long-term SIVmac nonprogression in Chinese rhesus macaques (Macaca mulatta).
Smith et al., Davis, United States. In J Med Primatol, 2011
The region of greatest LD difference was located on the proximal end of chromosome one, which also contained the genes ELAVL4, MAST2 and HIVEP3.
[MAST2-like protein kinase from grape vine Vitis vinifera: cloning of catalytic domain cDNA].
Nadezhdina et al., In Tsitol Genet, 2010
Using bioinformatic approach, we found genes of putative homologues of microtubule-associated mammalian protein kinase MAST2 in higher plant genomes.
Bioinformatic search of plant microtubule-and cell cycle related serine-threonine protein kinases.
Blume et al., Ukraine. In Bmc Genomics, 2009
A bioinformatic search was carried for plant homologues of human serine-threonine protein kinases involved in regulation of cell division and microtubule protein phosphorylation (SLK, PAK6, PAK7, MARK1, MAST2, TTBK1, TTBK2, AURKA, PLK1, PLK4 and PASK).
Attenuation of rabies virulence: takeover by the cytoplasmic domain of its envelope protein.
Lafon et al., Paris, France. In Sci Signal, 2009
Neuronal survival requires the selective association of the PDZ-BS of G with the PDZ domains of two closely related serine-threonine kinases, MAST1 and MAST2.
Novel family of human transposable elements formed due to fusion of the first exon of gene MAST2 with retrotransposon SVA.
GeneRIF
Buzdin et al., Moscow, Russia. In Biochemistry (mosc), 2009
Recruitment of a MAST2 CpG island was most likely beneficial to the hybrid retrotransposons because it could significantly increase retrotransposition frequency.
Exon-trapping mediated by the human retrotransposon SVA.
GeneRIF
Kazazian et al., Philadelphia, United States. In Genome Res, 2009
Studies report the identification of a new subfamily of SVA, which apparently formed after an alternative splicing event where the first exon of the MAST2 gene spliced into an intronic SVA and subsequently retrotransposed.
[Bioinformatic search of plant protein kinases, participating in microtubule protein phosphorylation and cell division regulation].
Blium et al., In Tsitol Genet, 2009
Bioinformatic search of plant homologues of human protein kinases SLK, PAK6, PAK7, MARK1, MAST2, TTBK1, TTBK2, AURKA, PLK1, PLK2 and PASK participating in microtubular protein phosphorylation and cell division regulation is carried out.
Coexpression of MAST205 inhibits the activity of Na+/H+ exchanger NHE3.
GeneRIF
Yun et al., Atlanta, United States. In Am J Physiol Renal Physiol, 2006
MAST205 regulates NHE3 activity and, although the precise mechanism is yet to be determined, MAST205 appears to inhibit NHE3 activity through a phosphorylation-dependent mechanism.
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