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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Spastic paraplegia 21

The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. At least three different transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, SRA, ACID, SET
Papers on MAST
Janicki et al., Columbia, United States. In Ijc Metab Endocr, Apr 2016
BACKGROUND: Cardiac mast cell (MC) proteases, chymase and tryptase, increase proliferation and collagen synthesis in cultured cardiac fibroblasts.
Host Foxp3+CD4+ Regulatory T Cells Act as a Negative Regulator of Dendritic Cells in the Peritransplantation Period.
Ogawa et al., Japan. In J Immunol, Feb 2016
To address this issue, we established a murine MHC-haploidentical BMT model (BDF1 (H-2b/d) → B6C3F1 (H-2b/k)), in which transplantation following conditioning with high-dose (13 Gy) or low-dose (5 Gy) total body irradiation corresponds to myeloablative stem cell transplantation (MAST) or reduced-intensity stem cell transplantation (RIST) BMT.
Mekori et al., In Harefuah, Aug 2015
A non-clonal mast cell activation syndrome is a newly emerged diagnosis.
Estimating the prevalence of mixed-type gonococcal infections in Queensland, Australia.
Whiley et al., In Sex Health, Aug 2015
Methods: Neisseria gonorrhoeae strains were categorised into three different porB groups, based on sequence data derived from N. gonorrhoeae multi-antigen sequence typing (NG-MAST) analyses of local isolates.
Emergence and evolution of internationally disseminated cephalosporin-resistant Neisseria gonorrhoeae clones from 1995 to 2005 in Japan.
Ohnishi et al., Tokyo, Japan. In Bmc Infect Dis, 2014
In recent years, multi-locus sequence typing (MLST) ST1901 and N. gonorrhoeae multiantigen sequence typing (NG-MAST) ST1407 isolates with the mosaic penicillin-binding protein (PBP) 2 XXXIV have accounted for most ESC resistance globally.
MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data.
Gottardo et al., Seattle, United States. In Genome Biol, 2014
MAST is available at .
Sequence information gain based motif analysis.
Perera et al., Barcelona, Spain. In Bmc Bioinformatics, 2014
SIGMA has been compared with different publicly available alternatives for motif detection, such as MEME/MAST, Biostrings (Bioconductor package), MotifRegressor, and previous work such Qresiduals projections or information theoretic based detectors.
Prevalence of bla TEM-220 gene in Penicillinase-producing Neisseria gonorrhoeae strains carrying Toronto/Rio plasmid in Argentina, 2002 - 2011.
Galarza et al., Buenos Aires, Argentina. In Bmc Infect Dis, 2014
In all TEM-220-producing isolates, the whole bla TEM gene was sequenced and the isolates were typed using N. gonorroheae multiantigen sequence typing (NG-MAST).
AGC protein kinases: from structural mechanism of regulation to allosteric drug development for the treatment of human diseases.
Biondi et al., Frankfurt am Main, Germany. In Biochim Biophys Acta, 2013
The group of AGC protein kinases includes more than 60 protein kinases in the human genome, classified into 14 families: PDK1, AKT/PKB, SGK, PKA, PKG, PKC, PKN/PRK, RSK, NDR, MAST, YANK, DMPK, GRK and SGK494.
Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer.
Chinnaiyan et al., Ann Arbor, United States. In Nat Med, 2011
We identified two classes of recurrent gene rearrangements involving genes encoding microtubule-associated serine-threonine kinase (MAST) and members of the Notch family.
Review and international recommendation of methods for typing neisseria gonorrhoeae isolates and their implications for improved knowledge of gonococcal epidemiology, treatment, and biology.
Dillon et al., Örebro, Sweden. In Clin Microbiol Rev, 2011
Currently, for microepidemiological questions, the best methods for fast, objective, portable, highly discriminatory, reproducible, typeable, and high-throughput characterization are N. gonorrhoeae multiantigen sequence typing (NG-MAST) or full- or extended-length porB gene sequencing.
[Effect of hepatitis B virus X gene on the expression of spastic paraplegia 21].
Hu et al., Ningbo, China. In Zhonghua Gan Zang Bing Za Zhi, 2010
HBV X gene enhanced SPG21 gene promoter activity, SPG21 mRNA expression and SPG21 protein production in HepG2 cells in a dose-dependent manner.
Targeted disruption of the Mast syndrome gene SPG21 in mice impairs hind limb function and alters axon branching in cultured cortical neurons.
Hanna et al., Stockholm, Sweden. In Neurogenetics, 2010
Mast syndrome gene SPG21 in mice has a role in hind limb function and axon branching in cultured cortical neurons
The nuts and bolts of AGC protein kinases.
Alessi et al., Dundee, United Kingdom. In Nat Rev Mol Cell Biol, 2010
The family comprises some intensely examined protein kinases (such as Akt, S6K, RSK, MSK, PDK1 and GRK) as well as many less well-studied enzymes (such as SGK, NDR, LATS, CRIK, SGK494, PRKX, PRKY and MAST).
Interaction of the SPG21 protein ACP33/maspardin with the aldehyde dehydrogenase ALDH16A1.
Blackstone et al., United States. In Neurogenetics, 2009
Data report that maspardin localizes prominently to cytoplasm as well as to membranes, possibly at trans-Golgi network/late endosomal compartments, and that maspardin interacts with the aldehyde dehydrogenase ALDH16A1.
Drosophila CLASP is required for the incorporation of microtubule subunits into fluxing kinetochore fibres.
Rieder et al., Albany, United States. In Nat Cell Biol, 2005
Here we use Drosophila melanogaster S2 cells expressing alpha-tubulin tagged with green fluorescent protein, RNA interference, laser microsurgery and photobleaching to show that the kinetochore protein MAST/Orbit - the single CLASP orthologue in Drosophila - is an essential component for microtubule subunit incorporation into fluxing K-fibres.
Maspardin is mutated in mast syndrome, a complicated form of hereditary spastic paraplegia associated with dementia.
Crosby et al., London, United Kingdom. In Am J Hum Genet, 2003
frameshift results in the premature termination of the encoded product, which is designated "maspardin" (Mast syndrome, spastic paraplegia, autosomal recessive with dementia)
Cell division: MAST sails through mitosis.
Sharp, United States. In Curr Biol, 2002
A recent study implicates the microtubule-associated protein MAST/Orbit in a surprisingly wide array of mitotic activities, ranging from maintaining mitotic spindle bipolarity to tethering chromosomes to the ends of microtubules.
Antiplatelet therapy in acute cerebral ischemia.
Gross et al., Burlington, United States. In Stroke, 1999
Only 1 study, the Multicentre Acute Stroke Trial-Italy (MAST-I), entered patients within 6 hours of the ictus.
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