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Carboxypeptidase A3, mast cell

mast cell carboxypeptidase A, MC-CPA, mMC-CPA, carboxypeptidase A3
Three different forms of human pancreatic procarboxypeptidase A have been isolated. This gene encodes a form which is obtained as a binary complex of a procarboxypeptidase A with proproteinase E and functions as a secretory granule metalloexopeptidase. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: carboxypeptidase, MAST, tryptase, chymase, CAN
Papers on mast cell carboxypeptidase A
Sputum mast cell subtypes relate to eosinophilia and corticosteroid response in asthma.
New
Gibson et al., Newcastle, Australia. In Eur Respir J, Jan 2016
Sputum mast cell subtypes were determined by molecular phenotyping based on expression of mast cell biomarkers (tryptase (TPSAB1), chymase (CMA1) and carboxypeptidase A3 (CPA3)).
Thymic stromal lymphopoietin controls prostaglandin D2 generation in patients with aspirin-exacerbated respiratory disease.
New
Laidlaw et al., Boston, United States. In J Allergy Clin Immunol, Jan 2016
Whole nasal polyp TSLP mRNA expression correlated strongly with mRNA encoding hematopoietic PGD2 synthase (r = .75), the mast cell-specific marker carboxypeptidase A3 (r = .74), and uPGD-M (r = 0.74).
[Diagnostic Significance of BAT in Anaphylaxis to Non-ionic Contrast Media].
New
Gao et al., In Fa Yi Xue Za Zhi, Jun 2015
OBJECTIVE: To investigate the diagnostic significance of basophil activation test (BAT) in anaphylaxis to non-ionic contrast media through testing the content of CD63, mast cell-carboxypeptidase A3 (MC-CPA3), and terminal complement complex SC5b-9 of the individuals by testing their levels in the normal immune group and the anaphylaxis groups to β-lactam drugs and non -ionic contrast media.
Mast cell proteases as pharmacological targets.
New
Caughey, San Francisco, United States. In Eur J Pharmacol, Jun 2015
In terms of relative amounts, the major mast cell proteases include the tryptases, chymases, cathepsin G, carboxypeptidase A3, dipeptidylpeptidase I/cathepsin C, and cathepsins L and S. Some mast cells also produce granzyme B, plasminogen activators, and matrix metalloproteinases.
Multidimensional endotypes of asthma: topological data analysis of cross-sectional clinical, pathological, and immunological data.
New
Impact
Djukanović et al., Geretsried, Germany. In Lancet, Mar 2015
BNA and TDA identified six novel clinicopathobiological clusters of underlying disease mechanisms, with elevated mast cell mediators tryptase (p<0·0001), chymase (p=0·02), and carboxypeptidase A3 (p=0·02) in severe asthma.
The Role of Mast Cell Specific Chymases and Tryptases in Tumor Angiogenesis.
Review
Jamur et al., Ribeirão Preto, Brazil. In Biomed Res Int, 2014
The major constituents of mast cell secretory granules are the mast cell specific proteases chymase, tryptase, and carboxypeptidase A3.
Pivotal role of mast cell carboxypeptidase A in mediating protection against small intestinal ischemia-reperfusion injury in rats after ischemic preconditioning.
Gan et al., Guangzhou, China. In J Surg Res, 2014
Mast cell carboxypeptidase A (MC-CPA) is released solely from MCs and plays a critical role in degrading toxins and endothelin 1 (ET-1).
Tryptase-PAR2 axis in experimental autoimmune prostatitis, a model for chronic pelvic pain syndrome.
Thumbikat et al., Chicago, United States. In Pain, 2014
Tryptase-β and carboxypeptidase A3 were elevated in CP/CPPS compared to healthy volunteers.
Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes.
Gibson et al., Newcastle, Australia. In J Allergy Clin Immunol, 2014
A signature of 6 genes, including Charcot-Leydon crystal protein (CLC); carboxypeptidase A3 (CPA3); deoxyribonuclease I-like 3 (DNASE1L3); IL-1β (IL1B); alkaline phosphatase, tissue-nonspecific isozyme (ALPL); and chemokine (C-X-C motif) receptor 2 (CXCR2), was reproducible and could significantly (P < .0001)
Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice.
GeneRIF
Galli et al., Stanford, United States. In Blood, 2012
Data suggest that carboxypeptidase A3 (Cpa3)-Cre; myeloid cell leukemia sequence 1 (Mcl-1)(fl/fl) mice may be useful in analyzing the roles of mast cells and basophils in health and disease.
Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity.
Impact
Rodewald et al., Heidelberg, Germany. In Immunity, 2011
Here, we show that targeted insertion of Cre-recombinase into the mast cell carboxypeptidase A3 locus deleted mast cells in connective and mucosal tissues by a genotoxic Trp53-dependent mechanism.
Mast cell proteases as protective and inflammatory mediators.
Review
Caughey, San Francisco, United States. In Adv Exp Med Biol, 2010
In other life-or-death examples, carboxypeptidase A3 and other mast cell peptidases limit systemic toxicity of endogenous peptideslike endothelin and neurotensin during septic peritonitis and inactivate venom-associated peptides.
Mast cell peptidases: chameleons of innate immunity and host defense.
Review
Caughey et al., San Francisco, United States. In Am J Respir Cell Mol Biol, 2010
The principal peptidases are tryptases, chymases, carboxypeptidase A3, and dipeptidylpeptidase I (cathepsin C).
In vitro diagnosis of anaphylaxis.
Review
Ferrer et al., Pamplona, Spain. In Chem Immunol Allergy, 2009
The in vitro diagnosis of anaphylaxis includes, among other aspects, the serial measurement of mediators which are released in the course of an anaphylactic reaction such as tryptase, histamine, chymase, carboxypeptidase A3, platelet-activating factor and other products from mastocytes.
Novel insights into the biological function of mast cell carboxypeptidase A.
Review
GeneRIF
Wernersson et al., Uppsala, Sweden. In Trends Immunol, 2009
Role in regulating innate immunity responses and regulating secretory granule homeostasis
Loss of histochemical identity in mast cells lacking carboxypeptidase A.
GeneRIF
Rodewald et al., Ulm, Germany. In Mol Cell Biol, 2005
Mc-cpa plays a crucial role for the generation of phenotypically mature mast cells.
A role for cathepsin E in the processing of mast-cell carboxypeptidase A.
GeneRIF
Pejler et al., Uppsala, Sweden. In J Cell Sci, 2005
cathepsin E is located in mast-cell secretory granules in complex with heparin proteoglycans, and has a role in the processing of procarboxypeptidase A into active protease
Cooperation between mast cell carboxypeptidase A and the chymase mouse mast cell protease 4 in the formation and degradation of angiotensin II.
GeneRIF
Pejler et al., Uppsala, Sweden. In J Biol Chem, 2004
mast cell chymase and CPA have key roles in both the generation and degradation of Ang II
Heparin is essential for the storage of specific granule proteases in mast cells.
Impact
Stevens et al., Boston, United States. In Nature, 1999
The mast cells in the skeletal muscle that normally contain heparin lacked metachromatic granules and failed to store appreciable amounts of mouse mast-cell protease (mMCP)-4, mMCP-5 and carboxypeptidase A (mMC-CPA), even though they contained substantial amounts of mMCP-7.
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