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Achaete-scute complex homolog 2

Mash2, Ascl2, HASH2
This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Insulin-Like Growth Factor II, p57, CAN, HAD, EH and
Papers on Mash2
OVO-like 1 regulates progenitor cell fate in human trophoblast development.
New
Soares et al., Kansas City, United States. In Proc Natl Acad Sci U S A, Dec 2015
OVOL1 was required to suppress genes that maintain cytotrophoblast cells in a progenitor state, including MYC, ID1, TP63, and ASCL2, and bound specifically to regions upstream of each of these genes.
Elevated expression of ASCL2 is an independent prognostic indicator in lung squamous cell carcinoma.
New
Bian et al., Chongqing, China. In J Clin Pathol, Nov 2015
AIMS: ASCL2, a basic helix-loop-helix (bHLH) transcription factor, is putatively involved in tumour progression.
Regulation of miRNAs by agents targeting the tumor stem cell markers DCLK1, MSI1, LGR5, and BMI1.
New
Houchen et al., Oklahoma City, United States. In Curr Pharmacol Rep, Sep 2015
Some recent studies on tumor stem cells and regulation of these miRNAs via agents targeting the tumor stem cell markers doublecortin-like kinase 1 (DCLK1), Musashi-1 (MSI1), polycomb protein BMI1, and WNT genes (LGR5 and ASCL2) will also be discussed.
Distribution of intestinal stem cell markers in colorectal precancerous lesions.
New
Kang et al., Cheju, South Korea. In Histopathology, Aug 2015
AIMS: Intestinal stem cell (ISC) markers such as LGR5, ASCL2, EPHB2 and OLFM4, and their clinical implications have been studied extensively in colorectal cancers (CRCs).
mRNA Levels of Imprinted Genes in Bovine In Vivo Oocytes, Embryos and Cross Species Comparisons with Humans, Mice and Pigs.
Tian et al., United States. In Sci Rep, 2014
Eighteen were detectable and their transcriptional patterns were: largely decreased (MEST and PLAGL1); first decreased and then increased (CDKN1C and IGF2R); peaked at a specific stage (PHLDA2, SGCE, PEG10, PEG3, GNAS, MEG3, DGAT1, ASCL2, NNAT, and NAP1L5); or constantly low (DIRAS3, IGF2, H19 and RTL1).
Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice.
GeneRIF
Clarke et al., Cardiff, United Kingdom. In Gut, 2012
Elevated expression of Ascl2 in a Wnt signalling dependent manner specifically in the stem cell compartment of the intestine neither increases tumour formation nor diminishes survival in a well established intestinal tumour model, the Apc(min) mouse.
Magnesium for aneurysmal subarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial.
Impact
MASH-2 Study Group et al., Utrecht, Netherlands. In Lancet, 2012
BACKGROUND: Magnesium sulphate is a neuroprotective agent that might improve outcome after aneurysmal subarachnoid haemorrhage by reducing the occurrence or improving the outcome of delayed cerebral ischaemia.
Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells.
GeneRIF
Wang et al., Chongqing, China. In Plos One, 2011
Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells
Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients.
Impact
Medema et al., Amsterdam, Netherlands. In Cell Stem Cell, 2011
We discovered that several Wnt target genes, including ASCL2 and LGR5, become silenced by CpG island methylation during progression of tumorigenesis, and that their re-expression was associated with reduced tumor growth.
Partial loss of Ascl2 function affects all three layers of the mature placenta and causes intrauterine growth restriction.
GeneRIF
Lefebvre et al., Vancouver, Canada. In Dev Biol, 2011
Partial loss of Ascl2 function affects all three layers of the mature placenta and causes intrauterine growth restriction.
Intravenous magnesium sulfate after aneurysmal subarachnoid hemorrhage: current status.
Review
Poon et al., Hong Kong, Hong Kong. In Acta Neurochir Suppl (wien), 2010
There are two multi-center phase III studies (IMASH and MASH2) being carried out to assess the clinical effects, in which IMASH has finished data collection on 30th June 2009.
Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain.
GeneRIF
Radlwimmer et al., Heidelberg, Germany. In Gut, 2010
a stem cell specific transcription signature promoted by ASCL2 has been identified to be upregulated in a subset of liver metastases, those characterised by an 11p15.5 gain
The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith-Wiedemann region.
GeneRIF
Nagy et al., Vancouver, Canada. In Hum Mol Genet, 2009
The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the mouse model of Beckwith-Wiedemann Syndrome.
The notch signalling pathway in the development of the mouse placenta.
Review
Otto et al., Freiburg, Germany. In Placenta, 2008
The analysis of mouse strains with targeted mutations in the Notch2, Notch1/4, Hey1/2, Dll4, RBPJkappa, and Mash2 genes has demonstrated that these genes are indispensable for a proper placental development.
Placental insufficiencies in cloned animals - a workshop report.
Review
Smith et al., Montréal, Canada. In Placenta, 2008
Moreover, an upstream transcription factor (Mash2) controlling the differentiation of trophoblast into binucleate cells may be involved in the poor implantation rates of SCNT embryos.
The evolution, regulation, and function of placenta-specific genes.
Review
Cross et al., Calgary, Canada. In Annu Rev Cell Dev Biol, 2007
A number of placenta-specific genes (e.g., Tpbp, Plac1, Syncytin, and retrotransposon-associated genes such as Peg10, Rtl1, Endothelin B receptor, Insl4, Leptin, Midline1, and Pleiotrophin), enhancer elements (e.g., glycoprotein hormone alpha-subunit) and gene isoforms (e.g., 3betaHSD, Cyp19), as well as placenta-specific members of gene families (e.g., Gcm1, Mash2, Rhox, Esx1, Cathepsin, PAG, TKDP, Psg, Siglec) have been identified.
Wnt signalling in the mouse intestine.
Review
Clarke, Cardiff, United Kingdom. In Oncogene, 2007
Together these approaches are being used to identify and validate key critical targets of the Wnt pathway, such as Mash2, Tiam1 and the Eph/Ephrins.
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.
Impact
Zhang et al., Chapel Hill, United States. In Nature, 2006
siRNA-mediated knockdown of JHDM3A leads to increased levels of H3K9 methylation and upregulation of a JHDM3A target gene, ASCL2, indicating that JHDM3A may function in euchromatin to remove histone methylation marks that are associated with active transcription.
Genomic imprinting of Mash2, a mouse gene required for trophoblast development.
Impact
GeneRIF
Nagy et al., Toronto, Canada. In Nat Genet, 1995
Mash2 gene is preferentially expressed from the paternal allele.
Essential role of Mash-2 in extraembryonic development.
Impact
Joyner et al., Toronto, Canada. In Nature, 1994
Lineage-specific transcription factors may be important in lineage specification, and the product of the Mash-2 gene fulfils the criteria for such a factor.
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