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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Methionyl-tRNA synthetase

MARS, SLA2, end4, Methionine-tRNA Ligase, Sla2p, MetRS
This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules. [provided by RefSeq, Jan 2011] (from NCBI)
Top mentioned proteins: CAN, ACID, Serum albumin, HAD, Actin
Papers using MARS antibodies
Assesment of relation between cognitive vulnerability and depression’s level by using classification and regression tree analysis
Supplier
Kayri M, In Iranian Journal of Public Health, 2007
... Data set to which MARS method is applied is taken from the Internet Dependency Scale (IDS), developed by Günüç (2009) ...
Papers on MARS
Temperature dependent mistranslation in a hyperthermophile adapts proteins to lower temperatures.
New
Pan et al., Chicago, United States. In Nucleic Acids Res, Feb 2016
Low-temperature mistranslation is facilitated by the misacylation of tRNA(Leu) with methionine by the methionyl-tRNA synthetase (MetRS).
Longitudinal Urinary Protein Variability in Participants of the Space Flight Simulation Program.
New
Domon et al., Luxembourg, Luxembourg. In J Proteome Res, Feb 2016
In this study, the analysis of urine samples collected from healthy individuals, rigorously selected to take part in the MARS-500 spaceflight simulation program, provided a unique opportunity to estimate normal concentration ranges for an extended set of urinary proteins.
A dual fluorescent reporter for the investigation of methionine mistranslation in live cells.
New
Pan et al., Chicago, United States. In Rna, Feb 2016
UNASSIGNED: In mammalian cells under oxidative stress, the methionyl-tRNA synthetase (MetRS) misacylates noncognate tRNAs at frequencies as high as 10% distributed among up to 28 tRNA species.
Molecular adsorbent recirculating system and single-pass albumin dialysis in liver failure - a prospective, randomised crossover study.
New
Kortgen et al., Jena, Germany. In Crit Care, Dec 2015
To date, ECAD is conducted mainly with the Molecular Adsorbents Recirculating System (MARS).
Whole genome sequence to decipher the resistome of Shewanella algae, a multidrug-resistant bacterium responsible for pneumonia, Marseille, France.
New
Rolain et al., Marseille, France. In Expert Rev Anti Infect Ther, Dec 2015
UNASSIGNED: We characterize and decipher the resistome and the virulence factors of Shewanella algae MARS 14, a multidrug-resistant clinical strain using the whole genome sequencing (WGS) strategy.
A novel therapeutic target for peripheral nerve injury-related diseases: aminoacyl-tRNA synthetases.
New
Jeong et al., Seoul, South Korea. In Neural Regen Res, Oct 2015
Of 20 AminoARSs, we found that phenylalanyl-tRNA synthetase beta chain (FARSB), isoleucyl-tRNA synthetase (IARS) and methionyl-tRNA synthetase (MARS) mRNA expression was increased in spinal dorsal horn neurons on the injured side, but not in glial cells.
Identification of novel biomarkers in plasma for prediction of treatment response in patients with heart failure.
New
Impact
Ng et al., Groningen, Netherlands. In Lancet, Mar 2015
Plasma samples were depleted of 14 high abundance proteins with a multiple affinity removal system column (MARS).
Stepping Out of the Cytosol: AIMp1/p43 Potentiates the Link Between Innate and Adaptive Immunity.
Review
Decker et al., Houston, United States. In Int Rev Immunol, 2014
As a structural component of the multi-aminoacyl tRNA synthetase (mARS) complex, AIMp1, also known as p43, hasn't until recently been recognized for its prominent immunological functions.
Expanding Omics Resources for Improvement of Soybean Seed Composition Traits.
Review
Nguyen et al., Columbia, United States. In Front Plant Sci, 2014
This article also highlights the use of modern breeding approaches, such as genome-wide association studies (GWAS), genomic selection (GS), and marker-assisted recurrent selection (MARS) for developing superior cultivars.
Recent advances in Charcot-Marie-Tooth disease.
Review
Timmerman et al., Antwerp, Belgium. In Curr Opin Neurol, 2014
RECENT FINDINGS: Several new Charcot-Marie-Tooth disease-causing genes have been recently identified, further enlarging the genetic diversity and phenotypic variability, including: SBF1, DHTKD1, TFG, MARS, HARS, HINT1, TRIM1, AIFM1, PDK3 and GNB4.
Architecture and metamorphosis.
Review
Yang et al., Jupiter, United States. In Top Curr Chem, 2013
The human MSC consists of nine aaRSs (LysRS, ArgRS, GlnRS, AspRS, MetRS, IleRS, LeuRS, GluProRS, and bifunctional aaRs) and three scaffold proteins (AIMP1/p43, AIMP2/p38, and AIMP3/p18), and has a molecular weight of 1.5 million Dalton.
Non-catalytic regulation of gene expression by aminoacyl-tRNA synthetases.
Review
Fox et al., Cleveland, United States. In Top Curr Chem, 2013
In the second section on translational control, we recapitulate the roles of GluProRS in translation repression at the initiation step, auto-inhibition of E. coli thrS mRNA translation by ThrRS, and global translational arrest by phosphorylated human MetRS.
Dual role of methionyl-tRNA synthetase in the regulation of translation and tumor suppressor activity of aminoacyl-tRNA synthetase-interacting multifunctional protein-3.
GeneRIF
Kim et al., Seoul, South Korea. In Proc Natl Acad Sci U S A, 2012
Data show that aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (AIMP3)/p18 is released from aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (AIMP3) by UV irradiation-induced stress.
Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans.
GeneRIF
Bellen et al., Houston, United States. In Plos Biol, 2011
MARS2 is mutated in Autosomal Recessive Spastic Ataxia with Leukoencephalopathy patients.
Clathrin light chain directs endocytosis by influencing the binding of the yeast Hip1R homologue, Sla2, to F-actin.
GeneRIF
Lemmon et al., Miami, United States. In Mol Biol Cell, 2011
CLC directs endocytic progression by pruning the Sla2-actin attachments in the clathrin lattice, providing direction for membrane internalization
The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation.
GeneRIF
McGlade et al., Toronto, Canada. In J Immunol, 2011
In bone marrow-derived dendritic cells lacking SLAP and closely related SLAP2, downregulation of the granulocyte-macrophage colony-stimulating factor (GM-CSF)beta receptor is impaired.
Roles of Src-like adaptor protein 2 (SLAP-2) in GPVI-mediated platelet activation SLAP-2 and GPVI signaling.
GeneRIF
Kimura et al., Hiroshima, Japan. In Thromb Res, 2010
In platelets, SLAP-2 may have function as a negative regulator of GPVI-mediated signaling by interacting with c-Cbl.
Structural basis for translational fidelity ensured by transfer RNA lysidine synthetase.
Impact
Nureki et al., Yokohama, Japan. In Nature, 2009
However, the aminoacylation of tRNA(Ile2) by methionyl-tRNA synthetase (MetRS), before the modification by TilS, might lead to the misincorporation of methionine in response to isoleucine codons.
Yeast tRNA(Asp) recognition by its cognate class II aminoacyl-tRNA synthetase.
Impact
Moras et al., Strasbourg, France. In Nature, 1993
The five aminoacyl-tRNA synthetases whose crystal structures are known (MetRS, TyrRS and GlnRS in class I, SerRS and AspRS in class II) belong to different subgroups.
Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs.
Impact
Moras et al., Strasbourg, France. In Nature, 1990
Out of the 18 known aaRS, only 9 referred to as class I synthetases (GlnRS, TyrRS, MetRS, GluRS, ArgRS, ValRS, IleRS, LeuRS, TrpRS), display two short common consensus sequences ('HIGH' and 'KMSKS') which indicate, as observed in three crystal structures, the presence of a structural domain (the Rossman fold) that binds ATP.
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