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MAP/microtubule affinity-regulating kinase 4

MARK4, MARKL1, MAP/microtubule affinity-regulating kinase-like 1, MAP/microtubule affinity-regulating kinase 4
This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: MARK, AMPK, LKB1, ARK5, MARK3
Papers on MARK4
Atypical PKC phosphorylates microtubule affinity-regulating kinase 4 in vitro.
Hassan et al., New Delhi, India. In Mol Cell Biochem, Dec 2015
MAP/Microtubule affinity-regulating kinase 4 (MARK4), a Ser/Thr protein kinases, is related to the Par-1 (partitioning-defective) gene products, and is the human ortholog of Par-1.
Designing New Kinase Inhibitor Derivatives as Therapeutics Against Common Complex Diseases: Structural Basis of Microtubule Affinity-Regulating Kinase 4 (MARK4) Inhibition.
Hassan et al., New Delhi, India. In Omics, Nov 2015
MAP/microtubule affinity-regulating kinase 4 (MARK4) is associated with numerous diseases such as neurodegenerative disorders, obesity, cancer, and type 2 diabetes.
PKR-inhibitor binds efficiently with human microtubule affinity-regulating kinase 4.
Hassan et al., New Delhi, India. In J Mol Graph Model, Nov 2015
MAP/microtubule affinity-regulating kinase 4 (MARK4) plays a central role in the cellular physiology, and it is inseparably linked with many human diseases including cancer, diet induced obesity, type2 diabetes and neurodegenerative disorders.
De novo deleterious genetic variations target a biological network centered on Aβ peptide in early-onset Alzheimer disease.
CNR-MAJ collaborators et al., Rouen, France. In Mol Psychiatry, Sep 2015
The two de novo CNVs (an amyloid precursor protein (APP) duplication and a BACE2 intronic deletion) and 3/12 non-synonymous DNVs (in PSEN1, VPS35 and MARK4) targeted genes from a biological network centered on the Amyloid beta (Aβ) peptide.
Human microtubule affinity-regulating kinase 4 is stable at extremes of pH.
Imtaiyaz Hassan et al., New Delhi, India. In J Biomol Struct Dyn, Sep 2015
UNASSIGNED: MAP/microtubule affinity-regulating kinase 4 (MARK4) is a member of adenosine monophosphate-activated protein kinases, directly associated with cancer and neurodegenerative diseases.
Suggestive evidence on the involvement of polypyrimidine-tract binding protein in regulating alternative splicing of MAP/microtubule affinity-regulating kinase 4 in glioma.
Larizza et al., Milano, Italy. In Cancer Lett, May 2015
MAP/microtubule affinity-regulating kinase 4 (MARK4) is a serine-threonine kinase that phosphorylates microtubule-associated proteins taking part in the regulation of microtubule dynamics.
Mark4 promotes adipogenesis and triggers apoptosis in 3T3-L1 adipocytes by activating JNK1 and inhibiting p38MAPK pathways.
Sun et al., China. In Biol Cell, 2014
BACKGROUND INFORMATION: Microtubule affinity-regulating kinase 4 (MARK4) deficiency has been reported to negatively regulate diet-induced obesity and to mitigate insulin resistance in knockout mice, and thus may play a role in metabolic syndrome.
An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential.
Shaw et al., Los Angeles, United States. In Mol Cell, 2014
The ability of LKB1 to suppress Snail1 levels was independent of AMPK but required the related kinases MARK1 and MARK4.
Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) plays a role in cell cycle progression and cytoskeletal dynamics.
Larizza et al., Milano, Italy. In Eur J Cell Biol, 2014
MARK4 is a serine-threonine kinase that phosphorylates MAP proteins, increasing microtubule dynamics.
The structural analysis of MARK4 and the exploration of specific inhibitors for the MARK family: a computational approach to obstruct the role of MARK4 in prostate cancer progression.
Mathur et al., Pondicherry, India. In Mol Biosyst, 2014
In the present work, we predicted the three dimensional structure for the kinase domain of MARK4 and analyzed its structural properties.
Microtubule affinity-regulating kinase 4: structure, function, and regulation.
Hassan et al., New Delhi, India. In Cell Biochem Biophys, 2013
MAP/Microtubule affinity-regulating kinase 4 (MARK4) belongs to the family of serine/threonine kinases that phosphorylate the microtubule-associated proteins (MAP) causing their detachment from the microtubules thereby increasing microtubule dynamics and facilitating cell division, cell cycle control, cell polarity determination, cell shape alterations, etc.
The regulation and function of the NUAK family.
Zhao et al., Taipei, Taiwan. In J Mol Endocrinol, 2013
Twelve AMPK-related kinases (ARKs; BRSK1, BRSK2, NUAK1, NUAK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4, and MELK) have been identified recently.
Investigation of two Wnt signalling pathway single nucleotide polymorphisms in a breast cancer-affected Australian population.
Griffiths et al., Griffith, Australia. In Twin Res Hum Genet, 2011
Even though an association of the polymorphisms rs2850328 and rs2395 and breast cancer was not detected in our case-control study population, other variants within the PPP3CA and MARK4 genes may still be associated with breast cancer.
Regulation of AMPK by the ubiquitin proteasome system.
Willis et al., Durban, South Africa. In Am J Pathol, 2011
Other investigators found that AMPK regulatory components, including the AMPK α subunit and AMPK kinases NUAK1 and MARK4, can be ubiquitinated with atypical ubiquitin chains.
Differential signature of the centrosomal MARK4 isoforms in glioma.
Larizza et al., Milano, Italy. In Anal Cell Pathol (amst), 2010
The balance between the MARK4 isoforms is carefully guarded during neural differentiation but may be subverted in gliomagenesis.
Genome-wide analysis of genetic loci associated with Alzheimer disease.
EADI1 Consortium et al., Boston, United States. In Jama, 2010
per copy of the minor allele; P = 1.59x10(-11)) and rs597668 near EXOC3L2/BLOC1S3/MARK4 (OR, 1.18; 95% CI, 1.07-1.29;
The regulation and function of mammalian AMPK-related kinases.
Carling et al., London, United Kingdom. In Acta Physiol (oxf), 2009
Recently, 12 AMPK-related kinases (BRSK1, BRSK2, NUAK1, NUAK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK) were identified that are closely related by sequence homology to the catalytic domain of AMPK.
Multiple localization of endogenous MARK4L protein in human glioma.
Larizza et al., Milano, Italy. In Cell Oncol, 2008
demonstrated that the endogenous MARK4L colocalizes with centrosomes at all mitotic stages and resides in centrosome-enriched fractions.
Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains.
Alessi et al., Dundee, United Kingdom. In Biochem J, 2008
NUAK1 and MARK4 are substrates of USP9X
Identification of regulated genes during permanent focal cerebral ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4.
Schwaninger et al., Heidelberg, Germany. In J Neurochem, 2004
MARK4 is a functional protein kinase which specifically phosphorylates a cognate peptide substrate for the AMP-kinase family. On overexpression in heterologous cells functional wild-type protein, but not its kinase-dead mutant, decreased cell viability
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