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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

MAP/microtubule affinity-regulating kinase 1

MARK, MARK1
phosphorylates the microtubule binding domain of microtubule-associated proteins and facilitates microtubule disruption; plays a role in microtubule dynamics [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, MAPK, V1a, LKB1, p38
Papers using MARK antibodies
LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis.
Supplier
Gottardi Cara, In PLoS ONE, 2007
... Cruz Biotechnology, Santa Cruz, CA, USA), anti-phospho-AMPK (Clone 40H9, which recognizes phospho-threonine 172, Cell Signaling), anti-MARK (Abcam, Cambridge, MA, USA), anti-phospho-MARK ...
Papers on MARK
Microtubule affinity-regulating kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer.
New
Lam et al., Vancouver, Canada. In Int J Cancer, Dec 2015
Microtubule affinity-regulating kinases (MARKs) are involved in several cellular functions but few studies have correlated MARK kinase expression with cancer, and none have explored their role in lung cancer.
MARK-AGE standard operating procedures (SOPs): A successful effort.
New
Bürkle et al., Konstanz, Germany. In Mech Ageing Dev, Nov 2015
Within the MARK-AGE project, a population study (3337 subjects) was conducted to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any single marker.
A Aconitum coreanum polysaccharide fraction induces apoptosis of hepatocellular carcinoma (HCC) cells via pituitary tumor transforming gene 1 (PTTG1)-mediated suppression of the P13K/Akt and activation of p38 MAPK signaling pathway and displays antitumor activity in vivo.
New
Li et al., Harbin, China. In Tumour Biol, Aug 2015
Particularly, CACP (40 μg/ml) treatment or transfection with PTTG1 small interfering RNA (siRNA) could greatly reduce the phosphorylation of Akt (p-Akt) but increase phospho-p38 mitogen-activated protein kinase (p-p38 MARK) protein levels in H22 cells as compared with vehicle-treated cells.
Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate.
New
Baekelandt et al., Basel, Switzerland. In Faseb J, Jul 2015
Several of the identified peptides are involved in the regulation of microtubule (MT) dynamics, including microtubule-associating protein (MAP)/microtubule affinity-regulating kinase 1 (MARK1).
Properties, regulation, pharmacology, and functions of the K₂p channel, TRESK.
Review
New
Czirják et al., Budapest, Hungary. In Pflugers Arch, May 2015
Protein kinase A (PKA) and microtubule affinity-regulating (MARK) kinases can be applied in experiments to phosphorylate these sites of TRESK expressed in Xenopus oocytes, respectively.
Screening of Target Genes and Regulatory Function of miRNAs as Prognostic Indicators for Prostate Cancer.
Hui et al., Zhangjiakou, China. In Med Sci Monit, 2014
In GO and KEGG analysis, target genes of down-regulated miRNAs were significantly enriched in positive ion combination and JAK-STAT pathway annotation, respectively; the ones with up-regulated miRNAs were significantly enriched in the function of plasma membrane and MARK signaling pathway annotation, respectively.
MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.
Zhang et al., United States. In Plos One, 2014
Despite their important function in health and disease, it has been unclear how the activity of MARK/Par1 is regulated by signals from cell surface receptors.
Thioredoxin as a putative biomarker and candidate target in age-related immune decline.
Review
Dunston et al., Göteborg, Sweden. In Biochem Soc Trans, 2014
These hypotheses are being explored in the MARK-AGE study, and preliminary findings confirm an inverse correlation of surface Trx-1 with age.
Therapeutic integration of new molecule-targeted therapies with radiotherapy in lung cancer.
Review
Sánchez et al., Madrid, Spain. In Transl Lung Cancer Res, 2014
Other new pathways and agents are being studied, such as m-TOR pathway, bortezomib, heat shock protein 90 (Hsp90) inhibition, histone deacetylase inhibitors (HDACS), aurora kinases, mitogen activated protein kinases (MARK) and PARP inhibitors.
A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway.
Impact
Camargo et al., Boston, United States. In Nat Cell Biol, 2014
The Hippo-YAP pathway is an emerging signalling cascade involved in the regulation of stem cell activity and organ size.
Canonical and noncanonical roles of Par-1/MARK kinases in cell migration.
Review
McDonald, Cleveland, United States. In Int Rev Cell Mol Biol, 2013
The partitioning defective gene 1 (Par-1)/microtubule affinity-regulating kinase (MARK) family of serine-threonine kinases have diverse cellular roles.
Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.
Review
Li et al., Hong Kong, Hong Kong. In Int J Mol Sci, 2013
LKB1 dowcnstream pathways mainly include AMPK, microtubule affinity regulating kinase (MARK), salt-inducible kinase (SIK), sucrose non-fermenting protein-related kinase (SNRK) and brain selective kinase (BRSK) signalings, etc.
Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids.
Impact
Lemmon et al., Philadelphia, United States. In Cell, 2011
Here, we identify the KA1 domain (kinase associated-1 domain), found at the C terminus of yeast septin-associated kinases (Kcc4p, Gin4p, and Hsl1p) and human MARK/PAR1 kinases, as a membrane association domain that binds acidic phospholipids.
A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.
GeneRIF
Madden et al., Brisbane, Australia. In Twin Res Hum Genet, 2010
In the Australian GWAS, the SNP rs7530302 near MARK1 on chromosome 1 (p=1.90 x 10(-9) achieved genomewide significance for comorbid AD/ND.
Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism.
GeneRIF
Simonneau et al., Paris, France. In Hum Mol Genet, 2008
Overexpression and silencing of MARK1 resulted in significantly shorter dendrite length in mouse neocortical neurons and modified dendritic transport speed.
Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein.
Review
GeneRIF
Mandelkow et al., Hamburg, Germany. In Bmc Neurosci, 2007
Data show that protein kinases of the MARK family phosphorylate tau protein in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments.
Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity.
Impact
Hatakeyama et al., Sapporo, Japan. In Nature, 2007
We show here that H. pylori CagA specifically interacts with PAR1/MARK kinase, which has an essential role in epithelial cell polarity.
Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2.
GeneRIF
Mandelkow et al., Hamburg, Germany. In J Biol Chem, 2006
analysis of variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2
Microtubule affinity-regulating kinase 1 (MARK1) is activated by electroconvulsive shock in the rat hippocampus.
GeneRIF
Bae et al., Suwŏn, South Korea. In J Neurochem, 2005
MARK1 was maximally activated between 2 and 5 min after electroconvulsive shock
MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption.
Impact
Mandelkow et al., Hamburg, Germany. In Cell, 1997
MARK phosphorylates the microtubule-associated proteins tau, MAP2, and MAP4 on their microtubule-binding domain, causing their dissociation from microtubules and increased microtubule dynamics.
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