GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Microtubule-associated protein tau
MAPT, PHF-tau, FTDP-17
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008] (from
NCBI)
Papers using
MAPT
antibodies
PANTHER: a library of protein families and subfamilies indexed by function
Supplier
In Human Molecular Genetics, 2002
... FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities ...
Cortical amino acidergic pathways in Alzheimer's disease
Supplier
In Frontiers in Neuroanatomy, 1986
... (VGLUT-1, 1:5,000, AB5905: Chemicon); parvalbumin (PV, 1:1,000, AB11427: Abcam, Cambridge, United Kingdom); and an anti-human PHF-tau monoclonal antibody (clone AT8, 1:100, MN1020: Thermo Scientific; Waltham, MA, USA) ...
Papers on
MAPT
Predictive and prognostic values of Tau and BubR1 protein in prostate cancer and their relationship to the Gleason score.
New
İzmir, Turkey. In Med Oncol, 30 Jun 2013
The expression status of Tau protein was defined by IHC using the two types of Tau antibodies: anti-Tau-1 antibody (that recognizes Tau only in its dephosphorylated form) and anti-PHF-Tau antibody (that recognizes all isoforms of human Tau proteins independent of its phosphorylation status).
Trans-splicing correction of tau isoform imbalance in a mouse model of tau mis-splicing.
New
London, United Kingdom. In Hum Mol Genet, 03 Apr 2013
Abnormal metabolism of the tau protein is central to the pathogenesis of a number of dementias, including Alzheimer's disease.
Activated amelogenin Y-linked (AMELY) regulation and angiogenesis in human hepatocellular carcinoma by biocomputation.
New
Beijing, China. In Oncol Lett, 31 Mar 2013
The AMELY upstream regulation molecular network model was constructed with BUB1B, CST6, ESM1, HOXA5, LEF1, MAPT, MYBL2, NOTCH3, PLA2G1B, PROK1, ROBO1, SCML2 and UBE2C in HCC from a Gene Expression Omnibus (GEO) dataset by gene regulation network inference methods and our programming methods.
Resolving the polymorphism-in-probe problem is critical for correct interpretation of expression QTL studies.
New
Chapel Hill, United States. In Nucleic Acids Res, 21 Mar 2013
We find that the polymorphism-in-probe problem is insufficiently controlled by previous protocols, and illustrate this using some notable false-positive and false-negative examples in MAPT and PRICKLE1 that can be found in many eQTL databases.
Variation in tau isoform expression in different brain regions and disease states.
New
Cardiff, United Kingdom. In Neurobiol Aging, 19 Mar 2013
Abnormal tau inclusions, in selected regions of the brain, are a hallmark of the disease and the H1 haplotype of MAPT, the gene encoding tau, is the major risk factor in PSP.
Frontotemporal lobar degeneration: epidemiology, pathology, diagnosis and management.
Review
New
Indianapolis, United States. In Cns Drugs, Nov 2012
Recent advances in molecular biology and immunohistochemical staining techniques have further classified the FTLD spectrum disorders based upon the predominant neuropathological protein into three main categories: (i) microtubule-associated protein tau (FTLD-TAU); (ii) TAR DNA-binding protein-43 (FTLD-TDP); and (iii) fused in sarcoma protein (FTLD-FUS).
The genetics and neuropathology of frontotemporal lobar degeneration.
Review
New
Antwerp, Belgium. In Acta Neuropathol, Sep 2012
Molecular genetic studies identified five disease genes, of which the gene encoding the tau protein (MAPT), the growth factor precursor gene granulin (GRN), and C9orf72 with unknown function are most frequently mutated.
Relationship between genetic risk factors and markers for Alzheimer's disease pathology.
Review
New
Maastricht, Netherlands. In Biomark Med, Aug 2012
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by neuritic plaques (main constituent: β-amyloid [Aβ]) and neurofibrillary tangles (hyperphosphorylated tau protein) in the brain.
Tau alternative splicing in familial and sporadic tauopathies.
Review
New
London, United Kingdom. In Biochem Soc Trans, Aug 2012
Six tau isoforms differing in their affinity for microtubules are produced by alternative splicing from the MAPT (microtubule-associated protein tau) gene in adult human brain.
Copy number variations involving the microtubule-associated protein tau in human diseases.
Review
New
Rouen, France. In Biochem Soc Trans, Aug 2012
Mutations of the MAPT (microtubule-associated protein tau) gene are associated with FTLD (frontotemporal lobar degeneration) with tau pathology.
Secondary nucleating sequences affect kinetics and thermodynamics of tau aggregation.
GeneRIF
Richardson, United States. In Biochemistry, 2012
Data suggest that sequences throughout tau (in addition to PHF6/PHF6*) can seed amyloid formation or affect aggregation kinetics/thermodynamics.
Early improved and late defective cognition is reflected by dendritic spines in Tau.P301L mice.
GeneRIF
Leuven, Belgium. In J Neurosci, 2012
This study concluded that mutant protein Tau modulates cognition and morphology of spines similarly and in both directions, with pathology later in life coinciding with increased phosphorylation and relocalization of Tau from axons to soma and processes.
Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport.
GeneRIF
Chicago, United States. In Biochemistry, 2011
Addition of Hsp70 to a mixture of oligomeric and fibrillar tau aggregates prevents the toxic effect of these tau species on fast axonal transport.
Amyloid-β associated volume loss occurs only in the presence of phospho-tau.
GeneRIF
San Diego, United States. In Ann Neurol, 2011
Data indicate that Abeta-associated volume loss occurs only in the presence of phospho-tau in humans at risk for dementia.
Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study.
Impact
Jacksonville, United States. In Lancet Neurol, 2011
Microtubule-associated protein tau (MAPT) H1H1 genotype was more common in limbic-predominant AD (54 [70%]) than in hippocampal sparing AD (24 [46%]; p=0.011), but did not differ significantly between limbic-predominant and typical AD (204 [59%]; p=0.11).
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
Impact
GeneRIF
Marburg an der Lahn, Germany. In Nat Genet, 2011
Variation in MAPT gene is associated with tauopathy progressive supranuclear palsy.
Age-related impairment of ultrasonic vocalization in Tau.P301L mice: possible implication for progressive language disorders.
GeneRIF
Marseille, France. In Plos One, 2010
The vocalization disorder of old Tau.P301L mice could be, at least in part, reminiscent of language disorders of elderly suffering tauopathy.
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.
Impact
Albany, United States. In Nat Genet, 2010
We confirmed associations with SNCA and MAPT, replicated an association with GAK (using data from the NGRC and a previous study, P = 3.2 x 10(-9)) and detected a new association with the HLA region (using data from the NGRC only, P = 2.9 x 10(-8)), which replicated in two datasets (meta-analysis P = 1.9 x 10(-10)).
Genome-wide association study reveals genetic risk underlying Parkinson's disease.
Impact
Bethesda, United States. In Nat Genet, 2009
P = 2.24 x 10(-16)) and another at the MAPT locus (rs393152, OR = 0.77, P = 1.95 x 10(-16)).
Evolutionary toggling of the MAPT 17q21.31 inversion region.
Impact
GeneRIF
Cambridge, United States. In Nat Genet, 2008
We found that inversion of the MAPT region is similarly polymorphic in other great ape species, and we present evidence that the inversions occurred independently in chimpanzees and humans
