The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome.
New York City, United States. In Nat Genet, Dec 2015
Mutation analysis identified a broad spectrum of somatic mutations in key genes involved in epigenetic regulation (TET2, CREBBP, KMT2D (MLL2), KMT2C (MLL3), BRD9, SMARCA4 and CHD3) and signaling, including MAPK1, BRAF, CARD11 and PRKG1 mutations driving increased MAPK, NF-κB and NFAT activity upon T cell receptor stimulation.
MAPK-Activated Protein Kinases (MKs): Novel Insights and Challenges.
Hannover, Germany. In Front Cell Dev Biol, 2014
Downstream of MAPKs, such as classical/atypical ERKs and p38 MAPKs, but not of JNKs, signaling is often mediated by protein kinases which are phosphorylated and activated by MAPKs and, therefore, designated MAPK-activated protein kinases (MAPKAPKs).
Mechanisms of Photoaging and Cutaneous Photocarcinogenesis, and Photoprotective Strategies with Phytochemicals.
Málaga, Spain. In Antioxidants (basel), 2014
UV radiation reduces cellular antioxidant status by generating reactive oxygen species (ROS), and the resultant oxidative stress alters signal transduction pathways such as the mitogen-activated protein kinase (MAPK), the nuclear factor-kappa beta (NF-κB)/p65, the janus kinase (JAK), signal transduction and activation of transcription (STAT) and the nuclear factor erythroid 2-related factor 2 (Nrf2).
Overview of fundamental study of pazopanib in cancer.
More papers using
Tianjin, China. In Thorac Cancer, 2014
In an vitro study, pazopanib exerted anti-tumor effect through mechanisms including the Raf-MAPK/ERK (MEK)-extracellular signal-regulated kinase (ERK) pathway, and directly targeted on v-raf murine sarcoma viral oncogene homolog B (B-raf) as well.
An orally available small molecule inhibitor of c-Met, PF-2341066, reduces tumor burden in a pre-clinical model of ovarian cancer metastasis.
In Oncogene, 2009
... , phospho-ERK1/2, ERK1/2, phospho-JNK, JNK, phospho-p38 MAPK, p38 MAPK were from Cell Signaling (Danvers, MA) ... Review of the activation of TGF-beta in immunity
In Cell Communication and Signaling : CCS, 2008
... Inhibitors used were; PI3K inhibitor Wortmannin -100 nM, p38/MAPK inhibitor SB 202190 - 25 M, TGFβR1 kinase inhibitor SD 208 - 1 M (Sigma-Aldrich), MMP inhibitor BB94 - 60 nM (Tocris Biosciences) ... Toxicology of the Yessotoxins
In Toxins, 2007
... Anti-phospho-PKB (Ser-473), anti-phospho-MAPK, and horseradish-peroxidase (HRP) conjugated goat anti-rabbit IgG secondary antibodies were from Cell Signaling Technology (Danvers, MA, USA) ... Integrative genomic analyses identify MITF as a lineage serviva oncogene amplified in malignant melanoma.
In PLoS ONE, 2004
... SB202190, SB203580, α-MSH, DMSO and L-DOPA were purchased from Sigma (Sigma Aldrich, Milan, Italy), while MAPK inhibitor III, PD169316, SB202474, and SB220025 were purchased from Calbiochem (Merck, Milan, Italy) ... Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
In PLoS Biology, 2003
... Massachusetts, United States), K5, K1, loricrin (Fuchs Lab), involucrin, fillagrin (Covance, Berkeley, California, United States), MAPK, pSMAD2 (Cell Signaling, Beverly, Massachusetts, United States); ... Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses.
In PLoS ONE, 2002
... against ILK, FAK, GSK3β, 5-bromo-2-deoxyuridine (BrdU) (BD, Heidelberg, Germany), phospho-Akt Serine(S)473, Akt, phospho-p44/42 MAPK, p44/42 MAPK, GSK3β S9, GSK3α/β S21/9 (Cell Signaling, Frankfurt a.M., Germany), phospho-FAK ... A rapid method of total lipid extraction and purification
In Particle and Fibre Toxicology, 1958
... MAPK inhibitors, PD98059 (2'-amino-3'-methoxyflavone), SB203580 [4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole], and SP600125 (1,9-pyrazoloanthrone) were purchased from Merck (Darmstadt, Germany) ...