Key mediators of intracellular amino acids signaling to mTORC1 activation.
Changsha, China. In Amino Acids, May 2015
Apart from the presence of intracellular amino acids, Rag GTPases and Rheb, other mediators involved in intracellular amino acid signaling to mTORC1 activation include human vacuolar sorting protein-34 (hVps34) and mitogen-activating protein kinase kinase kinase kinase-3 (MAP4K3).
Leucine and mTORC1: a complex relationship.
Cardiff, United Kingdom. In Am J Physiol Endocrinol Metab, 2012
This discovery has sparked a wealth of research in this field, revealing several different signaling molecules involved in transducing the amino acid signal to mTORC1, including the Rag GTPases, MAP4K3, and Vps34/ULK1.
Signalling by amino acid nutrients.
Edmonton, Canada. In Biochem Soc Trans, 2011
Our recent work has revealed that PR61ϵ, a B56 family regulatory subunit of PP2A (protein phosphatase 2A), associates with and regulates the activity of MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3), a protein kinase regulated by amino acid sufficiency that acts upstream of mTORC1.
Regulation of protein synthesis by amino acids in muscle of neonates.
Houston, United States. In Front Biosci, 2010
The role of the amino acid transporters, SNAT2, LAT1, and PAT, in the modulation of mTORC1 activation and the role of amino acids in the activation of putative regulators of mTORC1, i.e., raptor, Rheb, MAP4K3, Vps34, and Rag GTPases, are discussed.