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Mitogen-activated protein kinase kinase kinase kinase 3

MAP4K3, germinal center kinase-like kinase, mitogen-activated protein kinase kinase kinase 3, MEK kinase 3, germinal center kinase-related protein kinase
This gene encodes a member of the Ste20 family of serine/threonine protein kinases. The protein belongs to the subfamily that consists of members, such as germinal center kinase (GCK), that are characterized by an N-terminal catalytic domain and C-terminal regulatory domain. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase kinase 1 (MEKK1). This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MEKK3, mTORC1, V1a, ACID, CAN
Papers on MAP4K3
Crosstalk between the TNF and IGF pathways enhances NF-κB activation and signaling in cancer cells.
Brodt et al., Canada. In Growth Horm Igf Res, Oct 2015
This effect was AKT-dependent and mediated via mitogen-activated protein kinase kinase kinase 3(MEKK3) activation.
Antitumor Effects and Mechanisms of AZD4547 on FGFR2-Deregulated Endometrial Cancer Cells.
Sim et al., Seoul, South Korea. In Mol Cancer Ther, Oct 2015
In addition, using kinome-wide inhibition profiling analysis, we first identified potential new target kinases of AZD4547, including MAP4K3, MAP4K5, IRR, RET, and FLT3.
Key mediators of intracellular amino acids signaling to mTORC1 activation.
Yin et al., Changsha, China. In Amino Acids, May 2015
Apart from the presence of intracellular amino acids, Rag GTPases and Rheb, other mediators involved in intracellular amino acid signaling to mTORC1 activation include human vacuolar sorting protein-34 (hVps34) and mitogen-activating protein kinase kinase kinase kinase-3 (MAP4K3).
Inhibition of EP2/EP4 signaling abrogates IGF-1R-mediated cancer cell growth: involvement of protein kinase C-θ activation.
Izumi et al., Tokushima, Japan. In Oncotarget, Apr 2015
PKC-θ kinase MAP4K3, which plays a pivotal role in PKC-θ activation, also affected growth signaling in the presence of EP2/EP4 antagonists.
A somatic MAP3K3 mutation is associated with verrucous venous malformation.
Greene et al., Boston, United States. In Am J Hum Genet, Apr 2015
c.1323C>G; NP_002392, p.Iso441Met) in mitogen-activated protein kinase kinase kinase 3 (MAP3K3) in three of six individuals.
Evaluation of drug-targetable genes by defining modes of abnormality in gene expression.
Choi et al., Taejŏn, South Korea. In Sci Rep, 2014
Computationally, PTPRF, PRKAR2B, MAP4K3, and RICTOR were calculated as highly drug-targetable genes for breast cancer.
A genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylation.
Avruch et al., Cambridge, United States. In Plos One, 2014
However, an indication that this group also bears attention is the presence of rpS6KB1 itself, Rac1 and MAP4K3, a protein kinase that supports amino acid signaling to rpS6KB1.
The prognostic role of intragenic copy number breakpoints and identification of novel fusion genes in paediatric high grade glioma.
Jones et al., United Kingdom. In Acta Neuropathol Commun, 2013
We further identified two novel fusion genes in pHGG - CSGALNACT2:RET and the complex fusion DHX57:TMEM178:MAP4K3.
Leucine and mTORC1: a complex relationship.
Tee et al., Cardiff, United Kingdom. In Am J Physiol Endocrinol Metab, 2012
This discovery has sparked a wealth of research in this field, revealing several different signaling molecules involved in transducing the amino acid signal to mTORC1, including the Rag GTPases, MAP4K3, and Vps34/ULK1.
Effects of mTOR Inhibitors on Components of the Salvador-Warts-Hippo Pathway.
Martinez-Agosto et al., Los Angeles, United States. In Cells, 2011
Expression analysis in the HepG2 and MCF7 cell lines demonstrated common expression of MST1/2/4, MAP4K3/4/5, STK 24 (MST3), STK25, STK39, Pak1, SLK, Stradα/β and TAO2.
The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells.
Tan et al., Taiwan. In Nat Immunol, 2011
enhanced expression in systemic lupus erythematosus
Signalling by amino acid nutrients.
Lamb et al., Edmonton, Canada. In Biochem Soc Trans, 2011
Our recent work has revealed that PR61ϵ, a B56 family regulatory subunit of PP2A (protein phosphatase 2A), associates with and regulates the activity of MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3), a protein kinase regulated by amino acid sufficiency that acts upstream of mTORC1.
Essential amino acid sensing, signaling, and transport in the regulation of human muscle protein metabolism.
Rasmussen et al., Galveston, United States. In Curr Opin Clin Nutr Metab Care, 2011
Recent studies have also identified other intracellular proteins, such as hVps34 and MAP4K3, and specific amino acid transporters as necessary links between amino acid availability and mTORC1.
Regulation of protein synthesis by amino acids in muscle of neonates.
Davis et al., Houston, United States. In Front Biosci, 2010
The role of the amino acid transporters, SNAT2, LAT1, and PAT, in the modulation of mTORC1 activation and the role of amino acids in the activation of putative regulators of mTORC1, i.e., raptor, Rheb, MAP4K3, Vps34, and Rag GTPases, are discussed.
PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR.
Lamb et al., Canada. In Mol Cell, 2010
Amino acid sufficiency phosphorylates MAP4K3/Ser170, activating mTORC1, but amino acid restriction causes MAP4K3 to interact with PP2A(T61 epsilon), promoting dephosphorylation of Ser170, MAP4K3 inhibition, and, inhibition of mTORC1 signaling.
MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins.
Martins et al., Leicester, United Kingdom. In Proc Natl Acad Sci U S A, 2009
MAP4K3 orchestrates activation of BAX via the concerted posttranscriptional modulation of PUMA, BAD, and BIM.
The essential role of MEKK3 in TNF-induced NF-kappaB activation.
Su et al., Houston, United States. In Nat Immunol, 2001
Using mitogen-activated protein kinase kinase kinase 3 (MEKK3)-deficient fibroblast cells, we found that MEKK3 plays a critical role in TNF-induced NF-kappaB activation.
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