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Microtubule-associated protein 4

MAP4, microtubule-associated protein 4
The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] (from NCBI)
Top mentioned proteins: ACID, MAP2, HAD, CAN, AP4
Papers on MAP4
Arabidopsis FH1 Formin Affects Cotyledon Pavement Cell Shape by Modulating Cytoskeleton Dynamics.
Cvrčková et al., Praha, Czech Republic. In Plant Cell Physiol, Feb 2016
The pavement cell shape alterations were enhanced by expression of the fluorescent microtubule marker GFP-MAP4.
A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells.
Zheng et al., Frederick, United States. In Nucleic Acids Res, Jan 2016
By global profiling of the SRSF3-regulated splicing events in human osteosarcoma U2OS cells, we found that SRSF3 regulates the expression of 60 genes including ERRFI1, ANXA1 and TGFB2, and 182 splicing events in 164 genes, including EP300, PUS3, CLINT1, PKP4, KIF23, CHK1, SMC2, CKLF, MAP4, MBNL1, MELK, DDX5, PABPC1, MAP4K4, Sp1 and SRSF1, which are primarily associated with cell proliferation or cell cycle.
Effect of microtubule-associated protein-4 on epidermal cell migration under different oxygen concentrations.
Zhang et al., Chongqing, China. In J Dermatol, Dec 2015
The results showed that under hyperoxic (40% and 65%) and hypoxic (1%) conditions, HaCaT cells were able to regulate cell microtubule dynamics by MAP4, thus promoting cell migration.
Identification of Novel Epigenetic Markers of Prostate Cancer by NotI-Microarray Analysis.
Kashuba et al., Moscow, Russia. In Dis Markers, 2014
Based on these data, we proposed the set of potential biomarkers for detection of prostate cancer and discrimination between prostate tumors with different malignancy and aggressiveness: BHLHE40, FOXP1, LOC285205, ITGA9, CTDSPL, FGF12, LOC440944/SETD5, VHL, CLCN2, OSBPL10/ZNF860, LMCD1, FAM19A4, CAND2, MAP4, KY, and LRRC58.
Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization.
Saunier et al., Paris, France. In Nat Commun, 2014
The identified mutations result in mild ciliary defects in patients but also reveal an unexpected role of IFT54 as a negative regulator of microtubule stability via MAP4 (microtubule-associated protein 4).
Knockdown of MAP4 and DNAL1 produces a post-fusion and pre-nuclear translocation impairment in HIV-1 replication.
Hope et al., Chicago, United States. In Virology, 2012
DNAL1 and MAP4 may exert their functions in the HIV life cycle at reverse transcription, prior to nuclear translocation.
Microtubule-associated protein 4 binds to actin filaments and modulates their properties.
Kotani et al., Hiratsuka, Japan. In J Biochem, 2012
Data indicate that MAP4 binding alters the properties of the actin filaments.
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
van Duijn et al., Leicester, United Kingdom. In Nat Genet, 2011
near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3
MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis.
McAinsh et al., Coventry, United Kingdom. In Nat Cell Biol, 2011
Data show that the tau-related protein MAP4 and the microtubule rescue factor CLASP1 are essential for maintaining spindle position and the correct cell-division axis.
Basis for MAP4 dephosphorylation-related microtubule network densification in pressure overload cardiac hypertrophy.
Cooper et al., Charleston, United States. In J Biol Chem, 2011
Basis for MAP4 dephosphorylation-related microtubule network densification in pressure overload cardiac hypertrophy.
MAP4 mechanism that stabilizes mitochondrial permeability transition in hypoxia: microtubule enhancement and DYNLT1 interaction with VDAC1.
Huang et al., Chongqing, China. In Plos One, 2010
there are two possible mechanisms triggered by MAP4: stabilization of MT networks; DYNLT1 modulation, which is connected with VDAC1, and inhibition of hypoxia-induced mitochondrial permeabilization
The emerging pathogenic and therapeutic importance of the anaplastic lymphoma kinase gene.
McDermott et al., Dublin, Ireland. In Eur J Cancer, 2010
This has been described in ALK-positive anaplastic large cell lymphoma in which ALK is fused to NPM (nucleolar protein gene) and in non-small cell lung cancer where ALK is fused to EML4 (Echinoderm microtubule-associated protein 4).
Predominant regulators of tubulin monomer-polymer partitioning and their implication for cell polarization.
Gullberg et al., Umeå, Sweden. In Cell Mol Life Sci, 2009
Four unrelated conserved proteins, XMAP215/Dis1/TOGp, MCAK, MAP4 and Op18/stathmin, have all been implicated as predominant regulators of tubulin monomer-polymer partitioning in animal cells.
Ablation of key oncogenic pathways by RITA-reactivated p53 is required for efficient apoptosis.
Selivanova et al., Stockholm, Sweden. In Cancer Cell, 2009
RITA-activated p53 unleashes the transcriptional repression of antiapoptotic proteins Mcl-1, Bcl-2, MAP4, and survivin; blocks the Akt pathway on several levels; and downregulates c-Myc, cyclin E, and beta-catenin.
Taxanes, microtubules and chemoresistant breast cancer.
McCann et al., Dublin, Ireland. In Biochim Biophys Acta, 2008
Moreover, overexpression of the drug efflux pump MDR-1/P-gp, altered expression of microtubule-associated proteins (MAPs) including tau, stathmin and MAP4 may help to identify those patients who are most at risk of recurrence and those patients most likely to benefit from taxane treatment.
Controlled light-exposure microscopy reduces photobleaching and phototoxicity in fluorescence live-cell imaging.
Manders et al., Amsterdam, Netherlands. In Nat Biotechnol, 2007
We show that CLEM reduces photobleaching sevenfold in tobacco plant cells expressing microtubule-associated GFP-MAP4 and reduces production of reactive oxygen species eightfold and prolongs cell survival sixfold in HeLa cells expressing chromatin-associated H2B-GFP.
Transcriptional targets of p53 that regulate cellular proliferation.
Lee et al., United States. In Crit Rev Eukaryot Gene Expr, 2006
The role of p53 in G2/M cell-cycle arrest in response to DNA damage is more complex, involving multiple targets that can generally be considered to impinge upon either the cell cycle (e.g., Cyclin-B, cdc2, cdc25C) or the mitotic machinery (i.e., Topoisomerase II, B99/Gtse-1, and MAP4).
The individualization of cancer therapy: the unexpected role of p53.
Yang et al., New Brunswick, United States. In Trans Am Clin Climatol Assoc, 2005
We review the effects of p53 on antimicrotubule drugs through transcriptional regulation of MAP4 and stathmin (Oncoprotein 18).
MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption.
Mandelkow et al., Hamburg, Germany. In Cell, 1997
MARK phosphorylates the microtubule-associated proteins tau, MAP2, and MAP4 on their microtubule-binding domain, causing their dissociation from microtubules and increased microtubule dynamics.
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