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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Microtubule-associated protein 2

MAP2, microtubule-associated protein 2, sec-1
regulates and organizes microtubules; may serve as a scaffolding protein for neuromodulatory activities [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, Glial Fibrillary Acidic Protein, nestin, ACID, Synaptophysin
Papers using MAP2 antibodies
Targeting neural precursors in the adult brain rescues injured dopamine neurons.
Supplier
Sham Mai Har, In PLoS ONE, 2008
... used were mouse anti-Nestin (1∶200, Chemicon, Temecula, CA), rabbit polyclonal anti-Tbr2 (1∶1000, Chemicon) and mouse anti-MAP2 (1∶500, Sigma Aldrich, St ...
Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin.
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Ehlers Michael D., In PLoS Biology, 2006
... (AB96361), mouse anti-β-actin, mouse anti-GluR2 (Chemicon), mouse anti-Rab4, mouse anti-EEA1 (BD Biosciences), mouse anti-FLAG, mouse anti-MAP2, mouse anti-αtubulin (Sigma), mouse anti-GFP (Roche), mouse anti-bassoon (Stressgen), rabbit anti-β-galactosidase (MP Biomedicals), mouse anti-β-galactosidase (Promega), rabbit ...
Generation of a conditional disruption of the Tsc2 gene
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Sahin Mustafa et al., In Nature neuroscience, 2006
... ephrin-A5, EphA5, Brn3b (H-18), (Santa Cruz), phospho-TSC2 (S664) (BioLegend), TSC1 (Zymed), TSC2 (Biosource), Tau1 (Chemicon), MAP2 (sigma), chimaerin1 (Abnova), Brn3a, SAD-A/B (Millipore) as ...
Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model
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Eckman Christopher B et al., In Molecular Neurodegeneration, 2004
... Protein expression was then analyzed by Western blot using anti-human tau (1:2000; DAKO), anti-MAP2 (1:1000; Cell Signaling) and anti-GAPDH (1:2000; BioDesign) ...
Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity.
Supplier
Landsberger Nicoletta, In PLoS ONE, 2003
... Anti- IKKγ and anti-MAP2 antibodies were obtained from Cell Signaling Technology (Danvers, MA) ...
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Papers on MAP2
Calpastatin inhibits motor neuron death and increases survival of hSOD1(G93A) mice.
New
Nixon et al., New York City, United States. In J Neurochem, Feb 2016
Our data indicate that overexpression of CAST in hSOD1(G93A) mice, which lowered calpain activation to levels comparable to WT mice, inhibited the abnormal breakdown of cytoskeletal proteins (spectrin, MAP2 and neurofilaments), and ameliorated motor axon loss.
MeHg Suppressed Neuronal Potency of Hippocampal NSCs Contributing to the Puberal Spatial Memory Deficits.
New
Bi et al., Wuhan, China. In Biol Trace Elem Res, Feb 2016
MeHg attenuated microtubule-associated protein-2 (MAP-2) expression in neurons and enhanced the glial fibrillary acidic protein (GFAP)-positive cell differentiation of hNSCs, thereby inducing degenerative changes in a dose-dependent manner.
Deletion of collapsin response mediator protein 4 results in abnormal layer thickness and elongation of mitral cell apical dendrites in the neonatal olfactory bulb.
New
Ohtani-Kaneko et al., Japan. In J Anat, Feb 2016
Our in vitro studies showed that deletion or knockdown of CRMP4 resulted in enhanced growth of MAP2-positive neurites, whereas overexpression of CRMP4 reduced their growth, suggesting a new role for CRMP4 as a suppressor of dendritic elongation.
PSA-NCAM positive neural progenitors stably expressing BDNF promote functional recovery in a mouse model of spinal cord injury.
New
Leschik et al., Mainz, Germany. In Stem Cell Res Ther, Dec 2015
Stem cell differentiation in vivo revealed an increase of neuronal and oligodendrocytic lineage differentiation by BDNF as evaluated by immunohistochemistry of the neuronal marker MAP2 (microtubule associated protein 2) and the oligodendrocytic markers ASPA (aspartoacylase) and Olig2 (oligodendrocyte transcription factor 2). Furthermore, axonal tracing showed a significant increase of biotin dextran amine positive corticospinal tract fibers in BDNF-GFP-cell transplanted animals caudally to the lesion site.
Acute diagnostic biomarkers for spinal cord injury: review of the literature and preliminary research report.
Review
New
Bullock et al., Miami, United States. In World Neurosurg, May 2015
RESULTS: Neurofilaments, cleaved-Tau, microtubule-associated protein 2, myelin basic protein, neuron-specific enolase, S100β, and glial fibrillary acidic protein were identified as structural protein biomarkers in SCI by this review process.
Human cerebral cortex Cajal-Retzius neuron: development, structure and function. A Golgi study.
Review
Marín-Padilla, United States. In Front Neuroanat, 2014
The essential emptiness observed in hematoxylin and eosin preparations (most commonly used) contrast sharply with the concentration of dendrites (the cortex' largest) obtained using special (MAP-2) stain for dendrites.
Sex Hormones Regulate Cytoskeletal Proteins Involved in Brain Plasticity.
Review
Camacho-Arroyo et al., Mexico. In Front Psychiatry, 2014
The expression pattern of proteins, such as actin, microtubule-associated protein 2, Tau, and glial fibrillary acidic protein, changes in a tissue-specific manner in the brain, particularly when variations in sex hormone levels occur during the estrous or menstrual cycles or pregnancy.
The MMP-1/PAR-1 Axis Enhances Proliferation and Neuronal Differentiation of Adult Hippocampal Neural Progenitor Cells.
Grilli et al., Novara, Italy. In Neural Plast, 2014
Under differentiating conditions, these cells give rise to a higher percentage of MAP-2(+) neurons and a reduced number of oligodendrocyte precursors, and no change in the number of astrocytes.
Aging in the nervous system of Caenorhabditis elegans.
Review
Nicholas et al., Sydney, Australia. In Commun Integr Biol, 2013
This review summarizes the recent literature on neuronal aging in C. elegans, including our own findings, which indicate a role for protein with tau-like repeats (PTL-1), the homolog of mammalian tau and MAP2/4, in maintaining neuronal integrity during aging.
SNAREpin assembly by Munc18-1 requires previous vesicle docking by synaptotagmin 1.
GeneRIF
Söllner et al., Heidelberg, Germany. In J Biol Chem, 2012
SNAREpin assembly by Munc18-1 requires previous vesicle docking by synaptotagmin 1.
The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of Toxoplasma gondii.
GeneRIF
Pfeffer et al., Düsseldorf, Germany. In J Biol Chem, 2012
the inducible multimerization of mGBP2 is dependent on a functional GTPase domain.
Munc18-1 regulates first-phase insulin release by promoting granule docking to multiple syntaxin isoforms.
GeneRIF
Thurmond et al., Indianapolis, United States. In J Biol Chem, 2012
a novel indirect role for Munc18-1 in facilitating syntaxin 4-mediated granule pre-docking to support first-phase insulin exocytosis.
The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies.
GeneRIF
Sontag et al., Newcastle, Australia. In J Biol Chem, 2012
The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn.
Differential impact of REM sleep deprivation on cytoskeletal proteins of brain regions involved in sleep regulation.
GeneRIF
Velázquez-Moctezuma et al., Mexico. In Neuropsychobiology, 2011
The MAP2 content only increased in the preoptic area at 24 h, and in the frontal cortex after 24 and 72 h of REM sleep deprivation.
[Intracellular brain regeneration: a new view].
Review
Pal'tsyn et al., In Vestn Ross Akad Med Nauk, 2011
Reprogrammed oligodendrocyte nuclei begin to express the neural specific markers NeuN and MAP2.
In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus.
Impact
Goldman et al., New York City, United States. In Nat Med, 2000
The resultant P/Talpha1:hGFP+ and E/nestin:enhanced (E)GFP+ cells expressed betaIII-tubulin or microtubule-associated protein-2; many incorporated bromodeoxyuridine, indicating their genesis in vitro.
MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption.
Impact
Mandelkow et al., Hamburg, Germany. In Cell, 1997
MARK phosphorylates the microtubule-associated proteins tau, MAP2, and MAP4 on their microtubule-binding domain, causing their dissociation from microtubules and increased microtubule dynamics.
Role of microtubule-associated proteins in the control of microtubule assembly.
Review
Impact
Cambiazo et al., Santiago, Chile. In Physiol Rev, 1995
The MAP family includes large proteins like MAP-1A, MAP-1B, MAP-1C, MAP-2, and MAP-4 and smaller components like tau and MAP-2C.
Binding of alpha-factor pheromone to yeast a cells: chemical and genetic evidence for an alpha-factor receptor.
Impact
Hartwell et al., In Cell, 1983
Unlabeled alpha-factor competed for binding of 35S-alpha-factor; the concentration dependence for competition indicated 9 X 10(5) binding sites per cell with a dissociation constant (KD) of 3 X 10(-7) M. The rates of association (kon = 3 X 10(3) M-1 sec-1) and dissociation (koff = 9 X 10(-4) sec-1) were consistent with the equilibrium constant.
Pygmy stars: first pair.
Impact
Zwicky, In Science, 1966
Also, two of the Balmer lines in absorption appear to be displaced toward the red by amounts which indicate the existence of an Einstein gravitational red shift corresponding to about 1000 km sec-1.
More papers using MAP2 antibodies
Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity
Supplier
Li Xiao-Jiang et al., In The Journal of Cell Biology, 2002
... Other antibodies used included mouse monoclonal antibodies against polyglutamine (1C2) and GFAP (Chemicon), MAP2 (AP20; BD Biosciences), monoclonal γ-tubulin (Sigma Aldrich), ...
Caldendrin, a novel neuronal calcium-binding protein confined to the somato-dendritic compartment.
Supplier
Finkelstein David, In PLoS ONE, 1997
... Primary antibodies were purchased from Chemicon (MAP2), Abcam (GFAP), Fisher Scientific (anti-CD44, ...
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