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Mitogen-activated protein kinase 10

MAP kinase, JNK3, Mitogen-Activated Protein Kinase 10
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p38, MAPK, V1a, ERK, CAN
Papers using MAP kinase antibodies
ERK5 is a target for gene amplification at 17p11 and promotes cell growth in hepatocellular carcinoma by regulating mitotic entry
Supplier
Leung H Y et al., In British Journal of Cancer, 2008
... at the following dilutions: anti-ERK5 1 : 500, anti-phospho ERK5 1 : 500, p44/42 MAP kinase 1 : 1000, anti-phospho p44/42 MAP kinase (Cell Signalling Technology, Hertfordshire, UK) and anti-alpha tubulin 1 : 8000 (Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
Probing tumor phenotypes using stable and regulated synthetic microRNA precursors
Supplier
Jacks Tyler et al., In Nature, 2004
... Amplification of Ki-ras and elevation of MAP kinase activity during mammary tumor progression in C3(1)/SV40 Tag transgenic mice ...
A bipartite mechanism for ERK2 recognition by its cognate regulators and substrates
Supplier
Shapiro Paul et al., In Journal of Cell Communication and Signaling, 2002
... Purified GST:LIN-1 was incubated in the absence or presence of 10 ng active p42 ERK2 MAP kinase (New England Biolabs, Beverly, MA) in MAP ...
An APAF-1 cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
Supplier
Pittman Randall N. et al., In The Journal of Cell Biology, 1998
... for Akt Serine-473 were from New England Biolabs, Inc., and a rabbit polyclonal phosphospecific antibody for MAP kinase threonine-202/tyrosine-204 was from Cell Signaling Technology ...
Src-mediated coupling of focal adhesion kinase to integrin αvβ5 in vascular endothelial growth factor signaling
Supplier
Cheresh David A. et al., In The Journal of Cell Biology, 1996
... The phospho-specific MAP kinase antibody was from New England Biolabs, and the phospho-FAK antibodies ...
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Papers on MAP kinase
Aryl hydrocarbon receptor-driven signals inhibit collagen synthesis in the gut.
New
Monteleone et al., Roma, Italy. In Eur J Immunol, Feb 2016
The inhibitory effect of Ficz on Map kinase activation and collagen induction was abolished by AhR silencing.
Leishmania mexicana promastigotes down regulate JNK and p-38 MAPK activation: role in the inhibition of camptothecin-induced apoptosis of monocyte-derived dendritic cells.
New
Gutiérrez-Kobeh et al., Mexico. In Exp Parasitol, Feb 2016
In the present study, we analyzed the effect of L. mexicana promastigotes in the activation of JNK and p38 MAP kinase and their participation in the inhibition of apoptosis.
CXCR4 and CXCR7 Mediate TFF3-Induced Cell Migration Independently From the ERK1/2 Signaling Pathway.
New
Paulsen et al., Erlangen, Germany. In Invest Ophthalmol Vis Sci, Feb 2016
Trefoil factor family 3 also activated the MAP kinase signaling cascade independently from receptor activity.
Phosphorylation of αB-crystallin: Role in stress, aging and patho-physiological conditions.
Review
New
Rao et al., Hyderābād, India. In Biochim Biophys Acta, Jan 2016
Phosphorylation of S45 is mediated by p44/42 MAP kinase, whereas S59 phosphorylation is mediated by MAPKAP kinase-2.
Direct interaction of Ste11 and Mkk1/2 through Nst1 integrates high-osmolarity glycerol and pheromone pathways to the cell wall integrity MAPK pathway.
New
Song et al., Seoul, South Korea. In Febs Lett, Jan 2016
Slt2, the MAP kinase of cell wall integrity pathway (CWI), is activated by heat stress even in the absence of upstream components of this pathway, suggesting a supplementary input for Slt2 activation.
New insights into the activation, interaction partners and possible functions of MK5/PRAK.
Review
New
Seternes et al., Tromsø, Norway. In Front Biosci, Dec 2015
MAP kinase-activated protein kinase 5 (MK5) was first described as a downstream target of the p38 MAP kinase pathway leading to its alternative acronym of p38-regulated/activated protein kinase (PRAK).
Regulation of N-Formyl Peptide Receptor Signaling and Trafficking by Arrestin-Src Kinase Interaction.
New
Prossnitz et al., Albuquerque, United States. In Plos One, Dec 2015
It was later revealed that arrestins also mediate GPCR internalization and recruit a number of signaling proteins including, but not limited to, Src family kinases, ERK1/2, and JNK3.
Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans.
New
Impact
Ruvkun et al., Boston, United States. In Nat Cell Biol, Oct 2015
An RNA interference screen revealed gene inactivations that act at multiple steps in lipid biosynthetic and kinase pathways upstream of MAP kinase to mediate the systemic communication of translation defects to induce detoxification genes.
JNK pathway signaling: a novel and smarter therapeutic targets for various biological diseases.
Review
New
Malik et al., Meerut, India. In Future Med Chem, Oct 2015
Three distinct genes JNK1, JNK2 and JNK3 have been identified as regulator of JNK pathway.
Human sex-determination and disorders of sex-development (DSD).
Review
New
McElreavey et al., Paris, France. In Semin Cell Dev Biol, Sep 2015
SOX family gene mutations, as well as mutations involving GATA4, FOG2 and genes involved in MAP kinase signaling have been associated with virilization in 46,XX individuals or with 46,XY gonadal dysgenesis.
Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo.
New
Impact
Zou et al., Oklahoma City, United States. In Nat Med, Apr 2015
Here we show that nicotine, a major constituent of cigarette smoke, selectively activates AMP-activated protein kinase α2 (AMPKα2) in adipocytes, which in turn phosphorylates MAP kinase phosphatase-1 (MKP1) at serine 334, initiating its proteasome-dependent degradation.
The interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway.
New
Impact
Nakayama et al., Chiba, Japan. In Immunity, Mar 2015
We found that interleukin-33 (IL-33)-ST2 signals selectively licensed memory Th2 cells to induce allergic airway inflammation via production of IL-5 and that the p38 MAP kinase pathway was a central downstream target of IL-33-ST2 in memory Th2 cells.
MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1.
New
Impact
Dai et al., Bar Harbor, United States. In Cell, Mar 2015
Signaling through RAS/MAP kinase pathway is central to biology.
An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ.
New
Impact
Spiegelman et al., Boston, United States. In Nature, Feb 2015
Here we show that ERK directly phosphorylates serine 273 of PPARγ in a robust manner and that Cdk5 suppresses ERKs through direct action on a novel site in MAP kinase/ERK kinase (MEK).
Targeting RTK Signaling Pathways in Cancer.
Review
Regad, Nottingham, United Kingdom. In Cancers (basel), 2014
The RAS/MAP kinase and the RAS/PI3K/AKT pathways play a key role in the regulation of proliferation, differentiation and survival.
Silent scaffolds: inhibition OF c-Jun N-terminal kinase 3 activity in cell by dominant-negative arrestin-3 mutant.
GeneRIF
Gurevich et al., Nashville, United States. In J Biol Chem, 2012
Silent scaffolds: inhibition OF c-Jun N-terminal kinase 3 activity in cell by dominant-negative arrestin-3 mutant.
JNK regulates the photic response of the mammalian circadian clock.
GeneRIF
Fukada et al., Tokyo, Japan. In Embo Rep, 2012
Mice deficient for neuron-specific isoform JNK3 have altered behavioural rhythms, with longer free-running period and compromised phase shifts to light.
Nonvisual arrestins function as simple scaffolds assembling the MKK4-JNK3α2 signaling complex.
GeneRIF
Gurevich et al., Nashville, United States. In Biochemistry, 2012
Arrestin-3 acts as a "true" scaffold, facilitating JNK3alpha2 phosphorylation by bringing it and MAP kinase kinase (MKK)4 together.
JNK3 maintains expression of the insulin receptor substrate 2 (IRS2) in insulin-secreting cells: functional consequences for insulin signaling.
GeneRIF
Bonny et al., Lausanne, Switzerland. In Plos One, 2011
Data show that JNK3 silencing strongly decreases Insulin Receptor Substrate 2 (IRS2) protein expression.
JNK isoforms differentially regulate neurite growth and regeneration in dopaminergic neurons in vitro.
GeneRIF
Lingor et al., Göttingen, Germany. In J Mol Neurosci, 2011
Data suggest that JNK isoforms are involved in differential regulation of neuronal death and regeneration, and that JNK3 appears to be required for regeneration and survival in the case of an environment permissive for regeneration.
More papers using MAP kinase antibodies
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
Supplier
Lingor Paul et al., In Journal of Molecular Neuroscience, 1996
... siRNA targeting rat JNK1, JNK2, JNK3 and EGFP (GFP-22 siRNA) were purchased from Qiagen (Hilden, Germany) ...
Mutational analysis of the mitogenic and transforming activities of the insulin-like growth factor I receptor
Supplier
Miller W. Todd et al., In Journal of Signal Transduction, 1995
... Membranes were stripped and reprobed with Akt and MAP kinase antibodies for normalization (Cell Signaling).
Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein
Supplier
Juliano R.L. et al., In The Journal of Cell Biology, 1995
... Antibodies to FAK (clone 77) and MEK were from Transduction Laboratories (Lexington, KY); antibodies to MAP kinase (Sc-93, 94) were from Santa Cruz Biotechnology ...
Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK
Supplier
Kunapuli Satya P. et al., In Purinergic Signalling, 1991
... Polyclonal anti-phospho-p44/42 MAP kinase (Thr202/Tyr204) and anti-p44/442 MAP kinase were from Cell Signaling Technology (Beverly, Mass.) ...
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