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Mitogen-activated protein kinase 10

MAP kinase, JNK3, Mitogen-Activated Protein Kinase 10
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using MAP kinase antibodies
ERK5 is a target for gene amplification at 17p11 and promotes cell growth in hepatocellular carcinoma by regulating mitotic entry
Leung H Y et al., In British Journal of Cancer, 2008
... at the following dilutions: anti-ERK5 1 : 500, anti-phospho ERK5 1 : 500, p44/42 MAP kinase 1 : 1000, anti-phospho p44/42 MAP kinase (Cell Signalling Technology, Hertfordshire, UK) and anti-alpha tubulin 1 : 8000 (Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
Probing tumor phenotypes using stable and regulated synthetic microRNA precursors
Jacks Tyler et al., In Nature, 2004
... Amplification of Ki-ras and elevation of MAP kinase activity during mammary tumor progression in C3(1)/SV40 Tag transgenic mice ...
A bipartite mechanism for ERK2 recognition by its cognate regulators and substrates
Shapiro Paul et al., In Journal of Cell Communication and Signaling, 2002
... Purified GST:LIN-1 was incubated in the absence or presence of 10 ng active p42 ERK2 MAP kinase (New England Biolabs, Beverly, MA) in MAP ...
An APAF-1 cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
Pittman Randall N. et al., In The Journal of Cell Biology, 1998
... for Akt Serine-473 were from New England Biolabs, Inc., and a rabbit polyclonal phosphospecific antibody for MAP kinase threonine-202/tyrosine-204 was from Cell Signaling Technology ...
Src-mediated coupling of focal adhesion kinase to integrin αvβ5 in vascular endothelial growth factor signaling
Cheresh David A. et al., In The Journal of Cell Biology, 1996
... The phospho-specific MAP kinase antibody was from New England Biolabs, and the phospho-FAK antibodies ...
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Papers on MAP kinase
Silent scaffolds: inhibition OF c-Jun N-terminal kinase 3 activity in cell by dominant-negative arrestin-3 mutant.
Gurevich et al., Nashville, United States. In J Biol Chem, 2012
Silent scaffolds: inhibition OF c-Jun N-terminal kinase 3 activity in cell by dominant-negative arrestin-3 mutant.
JNK regulates the photic response of the mammalian circadian clock.
Fukada et al., Tokyo, Japan. In Embo Rep, 2012
Mice deficient for neuron-specific isoform JNK3 have altered behavioural rhythms, with longer free-running period and compromised phase shifts to light.
Nonvisual arrestins function as simple scaffolds assembling the MKK4-JNK3α2 signaling complex.
Gurevich et al., Nashville, United States. In Biochemistry, 2012
Arrestin-3 acts as a "true" scaffold, facilitating JNK3alpha2 phosphorylation by bringing it and MAP kinase kinase (MKK)4 together.
JNK3 maintains expression of the insulin receptor substrate 2 (IRS2) in insulin-secreting cells: functional consequences for insulin signaling.
Bonny et al., Lausanne, Switzerland. In Plos One, 2011
Data show that JNK3 silencing strongly decreases Insulin Receptor Substrate 2 (IRS2) protein expression.
JNK isoforms differentially regulate neurite growth and regeneration in dopaminergic neurons in vitro.
Lingor et al., Göttingen, Germany. In J Mol Neurosci, 2011
Data suggest that JNK isoforms are involved in differential regulation of neuronal death and regeneration, and that JNK3 appears to be required for regeneration and survival in the case of an environment permissive for regeneration.
More papers using MAP kinase antibodies
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
Lingor Paul et al., In Journal of Molecular Neuroscience, 1996
... siRNA targeting rat JNK1, JNK2, JNK3 and EGFP (GFP-22 siRNA) were purchased from Qiagen (Hilden, Germany) ...
Mutational analysis of the mitogenic and transforming activities of the insulin-like growth factor I receptor
Miller W. Todd et al., In Journal of Signal Transduction, 1995
... Membranes were stripped and reprobed with Akt and MAP kinase antibodies for normalization (Cell Signaling).
Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein
Juliano R.L. et al., In The Journal of Cell Biology, 1995
... Antibodies to FAK (clone 77) and MEK were from Transduction Laboratories (Lexington, KY); antibodies to MAP kinase (Sc-93, 94) were from Santa Cruz Biotechnology ...
Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK
Kunapuli Satya P. et al., In Purinergic Signalling, 1991
... Polyclonal anti-phospho-p44/42 MAP kinase (Thr202/Tyr204) and anti-p44/442 MAP kinase were from Cell Signaling Technology (Beverly, Mass.) ...
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