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Methionyl aminopeptidase 1

MAP 1, MetAP1, peptidase M
Top mentioned proteins: aminopeptidase, ACID, CAN, HAD, T-kininogen
Papers on MAP 1
Rescuers' physical fatigue with different chest compression to ventilation methods during simulated infant cardiopulmonary resuscitation.
New
Nakstad et al., Oslo, Norway. In J Matern Fetal Neonatal Med, Jan 2016
RESULTS: CCaV-120 compared with a 3:1 C:V ratio resulted in a change during 5-min of CPR in HR 49 versus 40 bpm (p = 0.01), and MAP 1.7 versus -2.8 mmHg (p = 0.03); fatigue rated on a Likert scale 12.9 versus 11.4 (p = 0.2); and a significant decay in CC depth after 90 s (p = 0.03).
Chemical shift assignments of zinc finger domain of methionine aminopeptidase 1 (MetAP1) from Homo sapiens.
New
Bharatam et al., Hyderābād, India. In Biomol Nmr Assign, Oct 2015
Methionine aminopeptidase Type I (MetAP1) cleaves the initiator methionine from about 70 % of all newly synthesized proteins in almost every living cell.
Quality changes of cuttlefish stored under various atmosphere modifications and vacuum packaging.
New
Gkagtzis et al., Néa Ionía, Greece. In J Sci Food Agric, Oct 2015
RESULTS: It was found that cuttlefish shelf life reached 2, 2, 4, 8 and 8 days for control, VP, MAP 1, MAP 2 and MAP 3 (20% CO2 -80% N2 , 50% CO2 -50% N2 and 70% CO2 -30% N2 for MAP 1, 2 and 3, respectively) samples, respectively, judging by their sensorial attributes.
Methionine AminoPeptidase Type-2 inhibitors targeting angiogenesis.
New
Bowen et al., Atlanta, United States. In Curr Top Med Chem, Oct 2015
Methionine aminiopeptidase is a metalloenzyme with two structurally distinct forms in humans, Type-1 (MetAP-1) and Type-2 (MetAP-2).
Relationships Among Peripheral and Central Electrophysiological Measures of Spatial and Spectral Selectivity and Speech Perception in Cochlear Implant Users.
New
Abbas et al., Iowa City, United States. In Ear Hear, Jul 2015
For each MAP, a subset of 7 of 22 intracochlear electrodes was activated: adjacent (MAP 1), every other (MAP 2), or every third (MAP 3).
Proinsulin and MAP3865c homologous epitopes are a target of antibody response in new-onset type 1 diabetes children from continental Italy.
New
Sechi et al., Sassari, Italy. In Pediatr Diabetes, May 2015
The homologous MAP2404c70-85 and proinsulin (PI)46-61 peptides were recognized by 42.4 and 39% of new-onset T1D children and only in 5% of HCs (AUC = 0.76, AUC = 0.7, p < 0.0001); whereas the prevalence of Abs against MAP 1,4-α-gbp157-173 and PI64-80 peptides was 45.7 and 49.1% in new-onset T1D children, respectively, compared with 3.3% of HCs (AUC = 0.74 and p < 0.0001 in both).
Evaluation of multiple antigenic peptides based on the Chikungunya E2 protein for improved serological diagnosis of infection.
New
Rao et al., New Delhi, India. In Viral Immunol, Mar 2015
Our results indicate that MAP 1 seems to be an alternate antigen to full-length protein E2 for immunodiagnosis of CHIKV infections with high sensitivity and specificity.
Beta-aminoketones as prodrugs for selective irreversible inhibitors of type-1 methionine aminopeptidases.
Klein et al., Heidelberg, Germany. In Bioorg Med Chem Lett, 2014
We identified and characterized β-aminoketones as prodrugs for irreversible MetAP inhibitors that are selective for the MetAP-1 subtype.
Redox regulation of methionine aminopeptidase 2 activity.
Hogg et al., Sydney, Australia. In J Biol Chem, 2014
Protein translation is initiated with methionine in eukaryotes, and the majority of proteins have their N-terminal methionine removed by methionine aminopeptidases (MetAP1 and MetAP2) prior to action.
Influence of modified atmosphere packaging on meat quality parameters of turkey breast muscles.
Klein et al., Hannover, Germany. In J Food Prot, 2014
MAP 1-packaged meat showed the highest sensory, redness, and thiobarbituric acid-reactive substance values.
Nondestructive and continuous monitoring of oxygen levels in modified atmosphere packaged ready-to-eat mixed salad products using optical oxygen sensors, and its effects on sensory and microbiological counts during storage.
Kerry et al., Cork, Ireland. In J Food Sci, 2013
These were held under different modified atmosphere packaging (MAP) conditions (5% O2 , 5% CO2 , 90% N2 (MAPC-commercial control), 21% O2 , 5% CO2 , 74% N2 (MAP 1), 45% O2 , 5% CO2 , 50% N2 (MAP 2), and 60% O2 , 5% CO2 , 35% N2 (MAP 3)) and 4 °C for up to 10 d.
Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.
Liu et al., Baltimore, United States. In J Med Chem, 2013
While MetAP2 has been demonstrated to be a therapeutic target for inhibiting angiogenesis in mammals, MetAP1 seems to be vital for cell proliferation.
Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1.
Ma et al., Shanghai, China. In Bioorg Med Chem, 2013
In mammals, type 2 MetAP (MetAP2) is known to be important for angiogenesis, while type 1 MetAP (MetAP1) has been shown to play a pivotal role in cell proliferation.
Methionine aminopeptidases as potential targets for treatment of gastrointestinal cancers and other tumours.
Review
González-Gallego et al., León, Spain. In Curr Drug Targets, 2010
Two types of MetAP enzymes, MetAP-1 (type-I) and MetAP-2 (type-II), which have a similar three-dimensional structure despite a low homology in their sequences, have been described.
Protein N-terminal processing: substrate specificity of Escherichia coli and human methionine aminopeptidases.
GeneRIF
Pei et al., Columbus, United States. In Biochemistry, 2010
the substrate specificities of Escherichia coli MetAP1, human MetAP1, and human MetAP2 were systematically profiled
Kinetic and mutational studies of the number of interacting divalent cations required by bacterial and human methionine aminopeptidases.
GeneRIF
Liu et al., Baltimore, United States. In Biochemistry, 2007
Human MetAP1 is distinct from other members of the MetAP superfamily in the number of metal ions employed and likely mechanism of catalysis.
Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression.
GeneRIF
Liu et al., Baltimore, United States. In Proc Natl Acad Sci U S A, 2006
results suggest that MetAP1 plays an important role in G(2)/M phase of the cell cycle and that it may serve as a promising target for the discovery and development of new anticancer agents
Structural basis for the functional differences between type I and type II human methionine aminopeptidases.
GeneRIF
Matthews et al., Eugene, United States. In Biochemistry, 2005
A comparison of the structual differences between Type I and Type II methionine aminopeptidases.
Functional expression of human methionine aminopeptidase type 1 in Saccharomyces cerevisiae.
GeneRIF
Chang et al., Saint Louis, United States. In Protein Pept Lett, 2002
Data show that human methionine aminopeptidase 1 (MetAP1) fully rescued the slow growth phenotype associated with deletion of yeast MetAP1, suggesting that the yeast and human proteins may have similar roles in vivo.
Structure of human methionine aminopeptidase-2 complexed with fumagillin.
Impact
Clardy et al., Ithaca, United States. In Science, 1998
The molecular target of fumagillin is methionine aminopeptidase-2 (MetAP-2).
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