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Mannosidase, alpha, class 1A, member 1

Man9, Man9-mannosidase
This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the removal of 3 distinct mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD45, fibrillin-1, CAN, ACID, Endo
Papers on Man9
Single-chain antibody-fragment M6P-1 possesses a mannose 6-phosphate monosaccharide-specific binding pocket that distinguishes N-glycan phosphorylation in a branch-specific manner†.
New
Müller-Loennies et al., Atlanta, United States. In Glycobiology, Feb 2016
In contrast to MPR300, scFv M6P-1 does not bind phosphodiesters, monophosphorylated Man8 or mono- or diphosphorylated Man9 structures.
Automated N-glycan profiling of a mutant Trypanosoma rangeli sialidase expressed in Pichia pastoris, using tandem mass spectrometry and bioinformatics.
New
Kirpekar et al., Odense, Denmark. In Glycobiology, Dec 2015
N-linked glycans in Tr7 were predominantly neutral oligosaccharides with compositions Man8-16GlcNAc2, but also mono- and di-phosphorylated oligosaccharides in the forms of Man9-15P1GlcNAc2 and Man9-14P2GlcNAc2, respectively.
Glycopeptide mimetics recapitulate high-mannose-type oligosaccharide binding and function.
New
Bewley et al., Bethesda, United States. In Angew Chem Int Ed Engl, Jun 2015
Using the potent antiviral lectin griffithsin (GRFT) as a model, we identified by NMR spectroscopy, SPR, analytical ultracentrifugation, and microcalorimetry glycopeptides that fully recapitulate the specificity and kinetics of binding to Man9 GlcNAc2 Asn and a synthetic nonamannoside.
Assembling different antennas of the gp120 high mannose-type glycans on gold nanoparticles provides superior binding to the anti-HIV antibody 2G12 than the individual antennas.
New
Penadés et al., San Sebastián, Spain. In Carbohydr Res, Apr 2015
In order to re-build Man9GlcNAc2 clusters of the HIV gp120 glycoprotein, ∼2 nm gold glyconanoparticles (GNPs) were coated with the synthetic partial structures of Man9, the tetramannoside Manα1-2Manα1-2Manα1-3Manα1- and the pentamannoside Manα1-2Manα1-3[Manα1-2Manα1-6]Manα1-.
Construction of a high-mannose-type glycan library by a renewed top-down chemo-enzymatic approach.
New
Ito et al., Wako, Japan. In Chemistry, Mar 2015
A comprehensive method for the construction of a high-mannose-type glycan library by systematic chemo-enzymatic trimming of a single Man9-based precursor was developed.
Structural and kinetic dissection of the endo-α-1,2-mannanase activity of bacterial GH99 glycoside hydrolases from Bacteroides spp.
New
Williams et al., Melbourne, Australia. In Chemistry, Feb 2015
Glycoside hydrolase family 99 (GH99) was created to categorize sequence-related glycosidases possessing endo-α-mannosidase activity: the cleavage of mannosidic linkages within eukaryotic N-glycan precursors (Glc1-3 Man9 GlcNAc2 ), releasing mono-, di- and triglucosylated-mannose (Glc1-3 -1,3-Man).
Targeting N-glycan cryptic sugar moieties for broad-spectrum virus neutralization: progress in identifying conserved molecular targets in viruses of distinct phylogenetic origins.
Wang et al., Menlo Park, United States. In Molecules, 2014
Unlike 2G12, which is strictly specific for the high-density Man9GlcNAc2Asn (Man9)-clusters, GNA recognizes a number of N-glycan cryptic sugar moieties.
Lipid-linked oligosaccharides in membranes sample conformations that facilitate binding to oligosaccharyltransferase.
Im et al., Lawrence, United States. In Biophys J, 2014
To explore LLOs' preferred location, orientation, structure, and dynamics in membrane bilayers of three different lipid types (dilauroylphosphatidylcholine, dimyristoylphosphatidylcholine, and dioleoylphosphatidylcholine), we have modeled and simulated both eukaryotic (Glc3-Man9-GlcNAc2-PP-Dolichol) and bacterial (Glc1-GalNAc5-Bac1-PP-Undecaprenol) LLOs, which are composed of an isoprenoid moiety and an oligosaccharide, linked by pyrophosphate.
Sweet entanglements--protein:glycan interactions in two HIV-inactivating lectin families.
Review
Gronenborn et al., Pittsburgh, United States. In Biopolymers, 2013
Both families recognize different epitopes on high-mannose glycans, namely, Manα(1-2)Man units at the end of the D1 and D3 arms and α3,α6-mannopentaose at the central branch point of Man-8 or Man-9 for CVNH and OAAH lectins, respectively.
N-glycan Cryptic Antigens as Active Immunological Targets in Prostate Cancer Patients.
Wang, Menlo Park, United States. In J Proteomics Bioinform, 2012
For examples, HIV-1 and SARS-CoV display Man9 clusters and tri- or multi-antennary type II (Galβ1→4GlcNAc) chains (Tri/m-II), respectively; viral neutralizing antibodies often target these sugar moieties.
Differential expression and function of α-mannosidase I in stimulated naive and memory CD4+ T cells.
GeneRIF
Sawitzki et al., Berlin, Germany. In J Immunother, 2011
Complex N-glycans generated by enzymes such as a-mannosidase I inhibit the activation of naive T cells.
Protein quality control in the ER: the recognition of misfolded proteins.
Review
Thomas et al., Montréal, Canada. In Semin Cell Dev Biol, 2010
The folding sensor UGGT acts as an unusual molecular chaperone and covalently modifies the Man9 N-glycan of a misfolded protein by adding a glucose moiety and converts it to Glc1Man9 that rebinds the lectin calnexin.
The mammalian UPR boosts glycoprotein ERAD by suppressing the proteolytic downregulation of ER mannosidase I.
GeneRIF
Sifers et al., Houston, United States. In J Cell Sci, 2009
ERManI, by functioning as a downstream effector target of EDEM1, represents a checkpoint activation paradigm by which the mammalian unfolded protein response coordinates the boosting of endoplasmic reticulum (ER)-associated degradation.
Stimulation of ERAD of misfolded null Hong Kong alpha1-antitrypsin by Golgi alpha1,2-mannosidases.
GeneRIF
Herscovics et al., Kyoto, Japan. In Biochem Biophys Res Commun, 2007
overexpression of Golgi alpha1,2-mannosidase IA, IB, and IC also accelerates ERAD of terminally misfolded human alpha1-antitrypsin variant null (Hong Kong) (NHK), and mannose trimming from the N-glycans on NHK in 293 cells
Activity of lysosomal exoglycosidases in saliva of patients with HIV infection.
GeneRIF
Zwierz et al., Białystok, Poland. In Adv Med Sci, 2006
following HIV infection, there is an increased rate of catabolism of glycoconjugates in saliva resulting from changes in the proportions of the activity of isoenzymes A and B of N-acetyl-beta-hexosaminidase, beta-galactosidase and alpha-fucosidase
The highly specific carbohydrate-binding protein cyanovirin-N: structure, anti-HIV/Ebola activity and possibilities for therapy.
Review
Gronenborn et al., Bethesda, United States. In Mini Rev Med Chem, 2005
CV-N's antiviral activity appears to involve unique recognition of N-linked high-mannose oligosaccharides, Man-8 and Man-9, on the viral surface glycoproteins.
Conformation-independent binding of monoglucosylated ribonuclease B to calnexin.
Impact
Bergeron et al., Montréal, Canada. In Cell, 1997
Using defined components, the binding of ribonuclease B (RNase B) Man7-Man9 glycoforms to the luminal domain of calnexin was observed in vitro only if RNase B was monoglucosylated.
Mammalian alpha-mannosidases--multiple forms but a common purpose?
Review
Warren et al., Waltham, United States. In Glycobiology, 1994
Based on new evidence, we propose that the ER/cytosolic mannosidase is involved in the degradation of dolichol intermediates that are not needed for protein glycosylation, whereas the soluble form of Man9-mannosidase is responsible for the degradation of glycans on defective or malfolded proteins that are specifically retained and broken down in the ER.
Membrane transport of sugar donors to the glycosylation sites.
Review
Cecchelli et al., In Biochimie, 1987
Combining the different results, obtained in several laboratories, it is suggested that the Man5-GlcNAc2-lipid is synthesized on the cytoplasmic side directly from the sugar-nucleotides and then translocated to the lumenal face where the Glc3-Man9-GlcNAc2-lipid is completed using Man-P-Dol and Glc-P-Dol as transmembrane carriers of these sugars.
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