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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Mastermind-like 2

MAML2, MAM-3, mastermind-like 2
Top mentioned proteins: mTORC1, HAD, MAML1, POLYMERASE, CAN
Papers on MAML2
Adenosquamous carcinoma of the head and neck: Molecular analysis using CRTC-MAML FISH and survival comparison with paired conventional squamous cell carcinoma.
New
Duvvuri et al., Loma Linda, United States. In Laryngoscope, Nov 2015
Additionally, 20 samples were sent for break-apart FISH testing to evaluate for the presence of the CRTC1-MAML2 translocation.
Warthin-like Mucoepidermoid Carcinoma: A Combined Study of Fluorescence In Situ Hybridization and Whole-slide Imaging.
New
Inagaki et al., Nagoya, Japan. In Am J Surg Pathol, Nov 2015
There has been some debate as to whether a subset of metaplastic Warthin tumors (mWTs) harbor the mucoepidermoid carcinoma (MEC)-associated CRTC1-MAML2 fusion.
Salivary Gland Cancers: Biology and Systemic Therapy.
Review
New
Ganti et al., In Oncology (williston Park), Oct 2015
For example, in mucoepidermoid carcinomas, one of the most common types of malignant salivary gland tumors, a commonly seen genetic translocation [t(11;19)(q21;p13), which involves the CRTC1 and MAML2 genes] has been found to be associated with improved survival, making it a possible prognostic marker.
Ciliated Adenosquamous Carcinoma: Expanding the Phenotypic Diversity of Human Papillomavirus-Associated Tumors.
New
Seethala et al., Pittsburgh, United States. In Head Neck Pathol, Oct 2015
Despite the occasional resemblance to mucoepidermoid carcinoma (MEC), the tumors showed focal keratinizing morphology and atypia, and all tumors were negative for MAML2 rearrangements.
Molecular Basis for the Mechanism of Constitutive CBP/p300 Coactivator Recruitment by CRTC1-MAML2 and Its Implications in cAMP Signaling.
New
Radhakrishnan et al., Evanston, United States. In Biochemistry, Oct 2015
Here we describe how both mechanisms could concurrently drive transcription of CREB targets in a subset of head and neck cancers featuring chromosomal translocations that fuse portions of CRTC1 and CRTC3 genes with that of the Mastermind-like transcriptional coactivator MAML2.
Expression Patterns of Circular RNAs from Primary Kinase Transcripts in the Mammary Glands of Lactating Rats.
New
Chen et al., Xuzhou, China. In J Breast Cancer, Sep 2015
Interestingly, four protein-coding genes (Rev3l, IGSF11, MAML2, and LPP) that also transcribe high levels of circRNAs have been reported to be involved in cancer.
Primary intraosseous mucoepidermoid carcinoma of the jaw: Reappraisal of the MD Anderson Cancer Center experience.
New
Weber et al., Houston, United States. In Head Neck, Sep 2015
The t(11;19) and its CRTC1-MAML2 fusion gene transcript have been identified in mucoepidermoid carcinoma and are associated with a subset of mucoepidermoid carcinomas.
A clear cell variant of mucoepidermoid carcinoma harboring CRTC1-MAML2 fusion gene found in buccal mucosa: report of a case showing a large clear cell component and lacking typical epidermoid cells and intermediate cells.
New
Koda et al., Shizuoka, Japan. In Med Mol Morphol, Sep 2015
Therefore, we performed fluorescence in situ hybridization to determine whether MAML2 rearrangement had occurred in this mass.
Molecular signature of salivary gland tumors: potential use as diagnostic and prognostic marker.
Review
New
Vargas et al., Piracicaba, Brazil. In J Oral Pathol Med, Jun 2015
Hence, gene rearrangements such as CRTC1-MAML2 in mucoepidermoid carcinomas have shown excellent specificity, and more than that, it has been strongly correlated with low-grade tumors and consequently with an increased survival rate and better prognosis of patients affected by neoplasms carrying this translocation.
Gene expression profiling analysis of CRTC1-MAML2 fusion oncogene-induced transcriptional program in human mucoepidermoid carcinoma cells.
Wu et al., Boston, United States. In Bmc Cancer, 2014
The majority of MEC tumors contain a t(11;19) chromosomal translocation that fuses two genes, CRTC1 and MAML2, to generate the chimeric protein CRTC1-MAML2.
Primary Pulmonary Mucoepidermoid Carcinoma: Histopathological and Moleculargenetic Studies of 26 Cases.
Liang et al., Beijing, China. In Plos One, 2014
MAML2 rearrangement was detected by fluorescence In Situ Hybridization (FISH).
Diagnostic and therapeutic implications of new molecular biomarkers in salivary gland cancers.
Review
Andersson et al., Göteborg, Sweden. In Oral Oncol, 2014
Prominent examples of clinically significant fusions are the MYB-NFIB fusion in adenoid cystic carcinoma and the CRTC1-MAML2 fusion in mucoepidermoid carcinoma.
Fusion oncogenes in salivary gland tumors: molecular and clinical consequences.
Review
Stenman, Göteborg, Sweden. In Head Neck Pathol, 2013
Examples of clinically significant gene fusions in salivary gland cancers are the MYB-NFIB fusion specific for adenoid cystic carcinoma, the CRTC1-MAML2 fusion typical of low/intermediate-grade mucoepidermoid carcinoma, and the recently identified ETV6-NTRK3 fusion in mammary analogue secretory carcinoma.
Molecular heterogeneity in mucoepidermoid carcinoma: conceptual and practical implications.
Review
El-Naggar et al., Houston, United States. In Head Neck Pathol, 2013
Despite this structural and cellular heterogeneity, MEC is uniquely characterized by a specific translocation t(11; 19) (q12; p13), resulting in a fusion between the MECT1 and the MAML2 genes.
Prospective testing of mucoepidermoid carcinoma for the MAML2 translocation: clinical implications.
GeneRIF
Seethala et al., Pittsburgh, United States. In Laryngoscope, 2012
The lack of significant correlation with histologic grade or pathologic stage implies that the previously reported prognostic value of the MAML2 translocation may be an artifact of misclassification of MEC as other tumors.
Fluorescence in situ hybridization for detection of MAML2 rearrangements in oncocytic mucoepidermoid carcinomas: utility as a diagnostic test.
GeneRIF
Seethala et al., Pittsburgh, United States. In Hum Pathol, 2011
The presence of MAML2 rearrangement can be used as supportive evidence to distinguish oncocytic mucoepidermoid carcinoma from other oncocytic lesions.
Impact of CRTC1/3-MAML2 fusions on histological classification and prognosis of mucoepidermoid carcinoma.
GeneRIF
Inagaki et al., Nagoya, Japan. In Histopathology, 2011
mucoepidermoid carcinoma of the salivary glands positive for CRTC1-MAML2 or CRTC3-MAML2 fusion formed a favourable tumour subset that was distinct from fusion-negative cases
High-level expression of Mastermind-like 2 contributes to aberrant activation of the NOTCH signaling pathway in human lymphomas.
GeneRIF
Mathas et al., Berlin, Germany. In Oncogene, 2011
in line with the essential role of MAML proteins for assembly and activity of the NOTCH transcriptional complex (NTC), we show that MAML-derived small-peptide constructs block NOTCH activity and disrupt NTC formation in vitro
CRTC1/MAML2 fusion transcript in central mucoepidermoid carcinoma of mandible--diagnostic and histogenetic implications.
GeneRIF
El-Naggar et al., Houston, United States. In Ann Diagn Pathol, 2010
The t(11;19) translocation and its CRTC1/MAML1 fusion transcript have been identified in mucoepidermoid carcinomas at different sites and are believed to be associated with the development of a subset of these tumors.
t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway.
Impact
GeneRIF
Kaye et al., Bethesda, United States. In Nat Genet, 2003
cloning and functional analyses of the t(11;19) fusion oncogene t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway.
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