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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Mastermind-like 1

MAML1, MAMI, Mastermind-like, Mastermind-like 1
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p300, CAN, galectin-1, CBF1, FATE
Papers on MAML1
Mastermind-like 3 controls proliferation and differentiation in neuroblastoma.
Bajpe et al., Netherlands. In Mol Cancer Res, Feb 2016
Using a gain-of-function genetic screen we identified an unexpected link between RA signaling and Mastermind-like 3 (MAML3), a known transcriptional coactivator for NOTCH.
β-catenin, a transcription factor activated by canonical Wnt signaling, is expressed in sensory neurons of calves latently infected with bovine herpesvirus 1.
Jones et al., Lincoln, United States. In J Virol, Feb 2016
ORF2 and a coactivator of β-catenin, mastermind like protein 1 (MAML1), stabilized β-catenin protein levels and stimulated β-catenin dependent transcription in mouse neuroblastoma cells more effectively than MAML1 or ORF2 alone.
Notch signaling in the nucleus: roles of Mastermind-like transcriptional coactivators.
Kitagawa, Chiba, Japan. In J Biochem, Jan 2016
UNASSIGNED: Notch signaling plays pivotal roles in development and homeostasis of all metazoan species.
Aberrant expression of Notch1, HES1, and DTX1 genes in glioblastoma formalin-fixed paraffin-embedded tissues.
Chand et al., Bengaluru, India. In Tumour Biol, Jan 2016
Using real-time PCR, we assessed the expression of Notch genes including receptors (Notch1, Notch2, Notch3, and Notch4), ligands (JAG1, JAG2, and DLL3), downstream targets (HES1 and HEY2), regulator Deltex1 (DTX1), inhibitor NUMB along with transcriptional co-activator MAML1, and a component of gamma-secretase complex APH1A in 15 formalin-fixed paraffin-embedded (FFPE) patient samples.
Genetic alteration in notch pathway is associated with better prognosis in renal cell carcinoma.
Hui et al., Shanghai, China. In Biofactors, Jan 2016
Alterations in KAT2B and MAML1 occurred in 13% and 19% of patients, respectively, both of which were functionally active in ccRCC.
Hypoxia but not normoxia promotes Smoothened transcription through upregulation of RBPJ and Mastermind-like 3 in pancreatic cancer.
Katano et al., Fukuoka, Japan. In Cancer Lett, Dec 2015
In the analysis of altered expressions of genes related to Hh signaling between under normoxia and hypoxia by DNA microarray analysis, we picked up 2 genes, a transcriptional regulator, recombination signal binding protein for immunoglobulin-kappa-J region (RBPJ) and a transcriptional co-activator, Mastermind-like 3 (MAML3).
Cancer stem cells in oesophageal squamous cell carcinoma: Identification, prognostic and treatment perspectives.
Lam et al., Gold Coast, Australia. In Crit Rev Oncol Hematol, Oct 2015
In oesophageal squamous cell carcinoma (ESCC), there are several markers such as CD44, ALDH, Pygo2, MAML1, Twist1, Musashi1, Side population (SP), CD271 and CD90 that have been proposed to identify the cancer stem cells in individual cancer masses.
Topography, clinical, and genomic correlates of 5q myeloid malignancies revisited.
Maciejewski et al., Cleveland, United States. In J Clin Oncol, 2012
In 31 of 33 patients with del(5q) AML, either a deletion involving the centromeric and/or telomeric regions or heterozygous mutations in NPM1 or MAML1 located in 5q35 were present.
Expression pattern of the glucosinolate side chain biosynthetic genes MAM1 and MAM3 of Arabidopsis thaliana in different organs and developmental stages.
Gershenzon et al., Jena, Germany. In Plant Physiol Biochem, 2012
We studied the expression patterns of MAM1 and MAM3 genes in different organs and developmental stages using promoter-GUS fusion lines and qRT-PCR.
Expression analysis elucidates the roles of MAML1 and Twist1 in esophageal squamous cell carcinoma aggressiveness and metastasis.
Abbaszadegan et al., Tehrān, Iran. In Ann Surg Oncol, 2012
Overexpression of MAML-1 and Twist1 were significantly associated with lymph node metastasis and the surgical staging of tumor
Conformational locking upon cooperative assembly of notch transcription complexes.
Blacklow et al., Boston, United States. In Structure, 2012
Association of CSL with NICD exerts remarkably little effect on the exchange kinetics of the ANK domain, whereas MAML1 binding greatly retards the exchange kinetics of ANK repeats 2-3.
Notch regulation of bone development and remodeling and related skeletal disorders.
Canalis et al., Hartford, United States. In Calcif Tissue Int, 2012
NICD induces gene expression by forming a ternary complex with the DNA binding protein CBF1/Rbp-Jk, Suppressor of Hairless, Lag1, and Mastermind-Like (Maml).
Ubiquitination of Notch1 is regulated by MAML1-mediated p300 acetylation of Notch1.
Wallberg et al., Stockholm, Sweden. In Biochem Biophys Res Commun, 2012
MAML1 increases Notch acetylation by potentiating p300 autoacetylation.
Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo.
Kitagawa et al., Chiba, Japan. In Development, 2011
Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo.
Targeting Notch signaling for cancer therapeutic intervention.
Liu et al., Miami, United States. In Adv Pharmacol, 2011
The NICD translocates to the nucleus, where it forms a complex with the DNA-binding protein CSL, displacing a histone deacetylase (HDAc)-corepressor (CoR) complex from CSL. Components of a transcriptional complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes.
A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA.
Bozzoni et al., Roma, Italy. In Cell, 2011
We show that linc-MD1 "sponges" miR-133 and miR-133 [corrected] to regulate the expression of MAML1 and MEF2C, transcription factors that activate muscle-specific gene expression.
Notch and the skeleton.
Canalis et al., Hartford, United States. In Mol Cell Biol, 2010
NICD then translocates to the nucleus, where it associates with the CBF-1, Suppressor of Hairless, and Lag-2 (CSL) and Mastermind-Like (MAML) proteins.
Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
Blacklow et al., Boston, United States. In Cell, 2006
Results report the crystal structure of a Notch transcriptional activation complex containing the ankyrin domain of human Notch1, the transcription factor CSL on cognate DNA, and a polypeptide from the coactivator Mastermind-like-1 (MAML-1).
t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway.
Kaye et al., Bethesda, United States. In Nat Genet, 2003
This rearrangement fuses exon 1 from a novel gene of unknown function at 19p13, termed mucoepidermoid carcinoma translocated 1 (MECT1), with exons 2-5 of a novel member of the Mastermind-like gene family (MAML2) at 11q21 (ref.
MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.
Griffin et al., Boston, United States. In Nat Genet, 2000
Here we clone MAML1, a human homologue of the Drosophila gene Mastermind, and show that it encodes a protein of 130 kD localizing to nuclear bodies.
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