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Malic enzyme 3, NADP

Malate Dehydrogenase, Me3
Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, MDH, CAN, fibrillin-1, HAD
Papers using Malate Dehydrogenase antibodies
Gene Set Enrichment Analysis (GSEA) at the Broad Institute
Kung Andrew L et al., In Genome Biology, 2004
... or HepG2 cell samples with RNA Pol II mAb (ab5408 - Abcam, Cambridge, MA, USA), H3K4 me3 pAb (ab8580 - Abcam), and H3K27 me3 pAb ...
Papers on Malate Dehydrogenase
Proteins involved in biophoton emission and flooding-stress responses in soybean under light and dark conditions.
Komatsu et al., Tsukuba, Japan. In Mol Biol Rep, Feb 2016
The highly abundant lactate/malate dehydrogenase proteins were decreased in flooding-stressed roots exposed to light, whereas the lysine ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme was increased in both light and dark conditions.
Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress.
Loscalzo et al., Boston, United States. In Cell Metab, Sep 2015
L2HG is a metabolite of unknown function produced by the reduction of mitochondrial 2-oxoglutarate by malate dehydrogenase.
Adaptations of protein structure and function to temperature: there is more than one way to 'skin a cat'.
Somero et al., Lancaster, United States. In J Exp Biol, Jun 2015
A series of studies using two structurally and catalytically related enzymes, A4-lactate dehydrogenase (A4-LDH) and cytosolic malate dehydrogenase (cMDH) have been especially valuable in determining the functional attributes of enzymes most sensitive to temperature, and identifying amino acid substitutions that lead to changes in those attributes.
Microsatellite instability: an update.
Imai et al., Kawasaki, Japan. In Arch Toxicol, Jun 2015
Trimethylation of histone H3 on Lys36 (H3K36 me3) is an epigenetic histone mark that was required for DNA MMR in vivo.
Unraveling the in vitro secretome of the phytopathogen Botrytis cinerea to understand the interaction with its hosts.
Jorrín-Novo et al., Ciudad Juárez, Mexico. In Front Plant Sci, 2014
By using proteomics as experimental approach, many secreted proteins by B. cinerea have been identified from in vitro experiments, and belonging to different functional categories: (i) cell wall-degrading enzymes such as pectinesterases and endo-polygalacturonases; (ii) proteases involved in host protein degradation such as an aspartic protease; (iii) proteins related to the oxidative burst such as glyoxal oxidase; (iv) proteins which may induce the plant hypersensitive response such as a cerato-platanin domain-containing protein; and (v) proteins related to production and secretion of toxins such as malate dehydrogenase.
Selection of reference genes for expression analyses of red-fleshed sweet orange (Citrus sinensis).
Latado et al., Piracicaba, Brazil. In Genet Mol Res, 2014
Phosphatase, malate dehydrogenase, and ACT were the most stable genes in the leaf samples of infected plants.
Effects of different dwarfing interstocks on key enzyme activities and the expression of genes related to malic acid metabolism in Red Fuji apples.
Xu et al., Baoding, China. In Genet Mol Res, 2014
The malate dehydrogenase (NAD-MDH) activity in apples on interstock No. 53 was highest on Day 30, Day 100, and Day 160 after bloom, and the malic enzyme (NADP-ME) activity in apples on interstock No. 111 was higher than in the interstock No. 53 fruit from Day 70 to Day 100 after bloom.
Evaluation of the In Vivo and In Vitro Effects of Fructose on Respiratory Chain Complexes in Tissues of Young Rats.
Schuck et al., Criciúma, Brazil. In Dis Markers, 2014
We here investigated the effect of acute fructose administration on the activities of mitochondrial respiratory chain complexes, succinate dehydrogenase (SDH), and malate dehydrogenase (MDH) in cerebral cortex, liver, kidney, and skeletal muscle of male 30-day-old Wistar rats.
The role of malic enzyme as the provider of NADPH in oleaginous microorganisms: a reappraisal and unsolved problems.
Ratledge, Kingston upon Hull, United Kingdom. In Biotechnol Lett, 2014
Its role in vivo depends on there being an adequate supply of NADH to drive malate dehydrogenase to convert oxaloacetate to malate as a component of a cycle of three reactions: pyruvate → oxaloacetate → malate and, by the action of ME, back to pyruvate.
Identification of mutant genes with high-frequency, high-risk, and high-expression in lung adenocarcinoma.
Mei et al., Shanghai, China. In Thorac Cancer, 2014
At fragments per kilobase per million reads (FPKM) ≥ 56.5, reported tumor suppressor genes catenin (cadherin-associated protein), delta (CTNND)1, dual specificity phosphatase (DUSP)6, malate dehydrogenase (MDH)1 and RNA binding motif protein (RBM)5, were identified.
Exocytosis and Endocytosis of Small Vesicles across the Plasma Membrane in Saccharomyces cerevisiae.
Chiang et al., State College, United States. In Membranes (basel), 2013
When Saccharomyces cerevisiae is starved of glucose, the gluconeogenic enzymes fructose-1,6-bisphosphatase (FBPase), phosphoenolpyruvate carboxykinase, isocitrate lyase, and malate dehydrogenase, as well as the non-gluconeogenic enzymes glyceraldehyde-3-phosphate dehydrogenase and cyclophilin A, are secreted into the periplasm.
Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency.
Plath et al., Los Angeles, United States. In Nat Cell Biol, 2013
We found that iPSCs, compared with both the starting fibroblasts and a late reprogramming intermediate (pre-iPSCs), are enriched for histone modifications associated with active chromatin, and depleted for marks of transcriptional elongation and a subset of repressive modifications including H3K9me2/me3.
Set3 HDAC mediates effects of overlapping noncoding transcription on gene induction kinetics.
Buratowski et al., Boston, United States. In Cell, 2012
Many Set3-repressed genes have H3K4me2 instead of me3 over promoter regions, due to either reduced H3K4me3 or ncRNA transcription from distal or antisense promoters.
Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.
Turck et al., München, Germany. In J Psychiatr Res, 2010
This protein has been found differentially expressed in thalami from patients with schizophrenia.
Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.
Mann et al., Martinsried, Germany. In Cell, 2010
Trimethyl-lysine (me3) modifications on histones are the most stable epigenetic marks and they control chromatin-mediated regulation of gene expression.
Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators.
Fisher et al., London, United Kingdom. In Nat Cell Biol, 2010
Jarid2-deficient ES cells showed reduced H3K4me2/me3 and H3K27me3 marking and PRC1/PRC2 recruitment, and did not efficiently establish Ser 5-phosporylated RNAP at target genes.
Functional roles of the tetramer organization of malic enzyme.
Hung et al., T'ai-chung-shih, Taiwan. In J Biol Chem, 2009
human c-NADP-ME exists mainly as a tetramer, whereas human m-NAD(P)-ME exists as a mixture of dimers and tetramers
Dual roles of Lys(57) at the dimer interface of human mitochondrial NAD(P)+-dependent malic enzyme.
Hung et al., T'ai-chung-shih, Taiwan. In Biochem J, 2009
Studies demonstrate that the Lys57 residue plays dual functional roles in the structural integrity of the allosteric site and in the subunit-subunit interaction at the dimer interface of m-NAD(P)-ME.
Influential factor contributing to the isoform-specific inhibition by ATP of human mitochondrial NAD(P)+-dependent malic enzyme: functional roles of the nucleotide binding site Lys346.
Hung et al., T'ai-chung-shih, Taiwan. In Febs J, 2008
ATP inhibition is proposed to be determined by the electrostatic potential involving the positive charge on the side chain of Lys346
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