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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 10 Oct 2015.

Toll-interleukin 1 receptor

Mal, TIRAP, BSAC, Wyatt
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MyD88, TLR4, CAN, TLR2, TRAM
Papers on Mal
Mal de Meleda: A Focused Review.
Khachemoune et al., Reno, United States. In Am J Clin Dermatol, 08 Nov 2015
UNASSIGNED: Mal de Meleda is a rare autosomal recessive palmoplantar keratoderma (PPK) disease with an estimated prevalence of 1:100,000.
Nanobody-Functionalized PEG-b-PCL Polymersomes and Their Targeting Study.
Li et al., Paris, France. In J Biotechnol, 30 Oct 2015
Fluorescein isothiocyanate (FITC) and N-beta-maleimidopropyl-oxysuccinimide ester were allowed reacting with H2N-PEG-b-PCL to produce FITC and maleimide (Mal) functionalized copolymers, Mal-PEG-b-PCL and FITC-PEG-b-PCL.
Identification of a Regulatory Acidic Motif as the Determinant of Membrane Localization of TICAM-2.
Seya et al., Sapporo, Japan. In J Immunol, 25 Oct 2015
UNASSIGNED: TLR4 triggers LPS signaling through the adaptors Toll/IL-1R domain-containing adaptor molecule (TICAM)-2 (also called TRAM) and TICAM-1 (also called TRIF), together with Toll/IL-1R domain-containing adaptor protein (TIRAP) and MyD88.
Editorial. Informed consent: the dawning of a new era.
In Br Dent J, 25 Oct 2015
Lord Justice Sedley in the case of Wyatt v Curtis [2003] laid a foundation for this Supreme Court Ruling (Montgomery v Lanarkshire Health Board [2015]), in that he argued there is 'something unreal about placing the onus of asking upon a patient who may not know that there is anything to ask about...'.
Toll-like receptor signalling through macromolecular protein complexes.
Gay et al., Cambridge, United Kingdom. In Mol Immunol, Feb 2015
Toll-like receptor 4 (TLR4) signals through two separate pairs of adaptor proteins Mal/MyD88 and Tram/Trif.
Toll/interleukin-1 receptor (TIR) domain-mediated cellular signaling pathways.
Park et al., Kyŏngsan, South Korea. In Apoptosis, Feb 2015
The Toll-like receptor/Interleukin (IL)-1 receptor (TLR/IL-1R) superfamily comprises proteins that contain the phylogenetically conserved Toll/IL-1 receptor (TIR) domain, which is responsible for the propagation of downstream signaling through recruitment of TIR domain containing cytosolic adaptor proteins such as MyD88, TIRAP/MAL, TRIF, TRAM and SARM.
Effects of dendritic core-shell glycoarchitectures on primary mesenchymal stem cells and osteoblasts obtained from different human donors.
Lips et al., Gießen, Germany. In J Nanobiotechnology, Dec 2014
We present a study on the biological interaction of maltose-modified poly(ethyleneimine) (PEI-Mal) on primary human mesenchymal stem cell, harvested from reaming debris (rdMSC) and osteoblasts obtained from four different male donors.
TLR2 and TLR4 in autoimmune diseases: a comprehensive review.
Lu et al., Changsha, China. In Clin Rev Allergy Immunol, Oct 2014
There are five adaptors to TLRs including MyD88, TRIF, TIRAP/MAL, TRAM, and SARM.
Antiretroviral therapy and the kidney.
Wyatt, New York City, United States. In Top Antivir Med, Jun 2014
This article summarizes a presentation by Christina M. Wyatt, MD, at the IAS-USA continuing education program held in Washington, DC, in June 2013.
A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction.
Kagan et al., Boston, United States. In Cell, Mar 2014
Here, we report that, in response to natural activators of innate immunity, the sorting adaptor TIRAP regulates TLR signaling from the plasma membrane and endosomes.
Clinical relevance of mupirocin resistance in Staphylococcus aureus.
Bonten et al., Utrecht, Netherlands. In J Hosp Infect, 2013
EUCAST and BSAC clinical thresholds for S. aureus are ≤1mg/L for susceptible and >256mg/L for resistant, placing the susceptible threshold at the epidemiological cut-off value (ECOFF).
The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.
Vanhaesebroeck et al., London, United Kingdom. In Nat Immunol, 2012
Lipopolysaccharide activates plasma-membrane signaling and endosomal signaling by Toll-like receptor 4 (TLR4) through the TIRAP-MyD88 and TRAM-TRIF adaptor complexes, respectively, but it is unclear how the signaling switch between these cell compartments is coordinated.
Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A.
Lagna et al., Boston, United States. In J Biol Chem, 2012
molecular inhibitory pathway linking BMP4 signaling, activation of MRTF-A, and inhibition of NF-kappaB provides insights into the etiology of PAH and a potential focus of therapeutic intervention.
Poxviral protein A46 antagonizes Toll-like receptor 4 signaling by targeting BB loop motifs in Toll-IL-1 receptor adaptor proteins to disrupt receptor:adaptor interactions.
Bowie et al., Dublin, Ireland. In J Biol Chem, 2012
Poxviral protein A46 inhibits TLR4 signaling and interacts with Toll-IL-1 receptor (TIR) domain-containing proteins of the receptor complex.
Toll-like receptor signal adaptor protein MyD88 is required for sustained endotoxin-induced acute hypoferremic response in mice.
Santos et al., Montréal, Canada. In Am J Pathol, 2012
Toll-like receptor signal adaptor protein MyD88 is required for sustained endotoxin-induced acute hypoferremic response in mice.
Phosphoinositide binding by the Toll adaptor dMyD88 controls antibacterial responses in Drosophila.
Kagan et al., Boston, United States. In Immunity, 2012
These data are reminiscent of the interactions between the mammalian Toll adaptors MyD88 and TIRAP with one major exception.
MAL facilitates the incorporation of exocytic uroplakin-delivering vesicles into the apical membrane of urothelial umbrella cells.
Sun et al., New York City, United States. In Mol Biol Cell, 2012
the exclusion of MAL from the expanding 2D crystals of uroplakins explains the selective association of MAL with the hinge areas in the uroplakin-delivering fusiform vesicles, as well as at the apical surface
The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils.
Morio et al., Tokyo, Japan. In Nat Immunol, 2012
In the absence of Btk, the adaptor Mal was associated with PI(3)K and PTKs at the plasma membrane, whereas in control resting neutrophils, Btk interacted with and confined Mal in the cytoplasm.
Structural insights into TIR domain specificity of the bridging adaptor Mal in TLR4 signaling.
Shen et al., Tianjin, China. In Plos One, 2011
The Mal-Toll/interleukin-1 receptor (TIR) domains AB loop is capable of mediating direct binding to the TIR domains of TLR4 and MyD88 simultaneously.
Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype.
Karsan et al., Vancouver, Canada. In Nat Med, 2010
We show that deletion of chromosome 5q correlates with loss of two miRNAs that are abundant in hematopoietic stem/progenitor cells (HSPCs), miR-145 and miR-146a, and we identify Toll-interleukin-1 receptor domain-containing adaptor protein (TIRAP) and tumor necrosis factor receptor-associated factor-6 (TRAF6) as respective targets of these miRNAs.
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