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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 04 Dec 2014.

Toll-interleukin 1 receptor

Mal, TIRAP, BSAC, Wyatt
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MyD88, TLR4, CAN, TLR2, TRAM
Papers on Mal
Characterising the proteome and oxi-proteome of apple in response to a host (Penicillium expansum) and a non-host (Penicillium digitatum) pathogen.
New
Torres et al., Lleida, Spain. In J Proteomics, 20 Dec 2014
While these changes showed some similarities between the apple responses to abiotic and biotic stresses, Mal d 1.03A case, other proteins as Mal d 1.03E and EF-Tu were specifically induced in response to P. digitatum infection.
Genetic variation in inflammatory and bone turnover pathways and risk of osteolytic responses to prosthetic materials.
New
Wilkinson et al., Sheffield, United Kingdom. In J Orthop Res, 16 Dec 2014
In the discovery cohort four SNPs within RANK, and one each within KREMEN2, OPG, SFRP1, and TIRAP (p < 0.05) were associated with osteolysis susceptibility.
Measurement Bias in Activation-Recovery Intervals from Unipolar Electrograms.
New
Taggart et al., London, United Kingdom. In Am J Physiol Heart Circ Physiol, 14 Dec 2014
The Wyatt method is well-established as a theoretically sound method for calculating ARIs; however, some studies have observed that it is prone to a bias error in measurement when applied to positive T-waves.
TRAM Is Required for TLR2 Endosomal Signaling to Type I IFN Induction.
New
Bowie et al., Dublin, Ireland. In J Immunol, 10 Dec 2014
TLR4 signaling from the plasma membrane to NF-κB via the Toll/IL-1R (TIR) adaptor protein MyD88 requires the TIR sorting adaptor Mal, whereas endosomal TLR4 signaling to IRF3 via the TIR domain-containing adaptor-inducing IFN-β (TRIF) requires the TRIF-related adaptor molecule (TRAM).
Polymorphisms in RNA sensing toll like receptor genes and its association with clinical outcomes of dengue virus infection.
New
Cecilia et al., Pune, India. In Immunobiology, 06 Nov 2014
DHF vs. HC P=0.040 OR with 95% CI 0.393 (0.162-0.956)] and higher frequency of TIRAP rs8177374 'C/T' genotype [DHF vs. HC P=0.020 OR with 95% CI 2.643 (1.167-5.986)] in DHF.
Toll-like receptor signalling through macromolecular protein complexes.
Review
New
Gay et al., Cambridge, United Kingdom. In Mol Immunol, Aug 2014
Toll-like receptor 4 (TLR4) signals through two separate pairs of adaptor proteins Mal/MyD88 and Tram/Trif.
A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction.
New
Impact
Kagan et al., Boston, United States. In Cell, Mar 2014
Here, we report that, in response to natural activators of innate immunity, the sorting adaptor TIRAP regulates TLR signaling from the plasma membrane and endosomes.
High pressure effects on allergen food proteins.
Review
New
Smeller et al., Budapest, Hungary. In Biophys Chem, Jan 2014
According to this criterion we selected the following allergen proteins: Mal d 1 and Mal d 3 (apple), Bos d 5 (milk), Dau c 1 (carrot), Gal d 2 (egg), Ara h 2 and Ara h 6 (peanut), and Gad m 1 (cod).
Clinical relevance of mupirocin resistance in Staphylococcus aureus.
Review
New
Bonten et al., Utrecht, Netherlands. In J Hosp Infect, Dec 2013
EUCAST and BSAC clinical thresholds for S. aureus are ≤1mg/L for susceptible and >256mg/L for resistant, placing the susceptible threshold at the epidemiological cut-off value (ECOFF).
Toll-like receptors' pathway disturbances are associated with increased susceptibility to infections in humans.
Review
New
Condino-Neto et al., São Paulo, Brazil. In Arch Immunol Ther Exp (warsz), Dec 2013
TLRs and IL-1R are a family of receptors related to the innate immune response that contain an intracellular domain known as the Toll-IL-1R (TIR) domain that recruits the TIR-containing cytosolic adapters MyD88, TRIF, TIRAP and TRAM.
Mal, more than a bridge to MyD88.
Review
New
O'Neill et al., Dublin, Ireland. In Iubmb Life, Sep 2013
This review will focus on one of those adaptors, MyD88 adaptor-like (Mal), also known as TIRAP.
The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.
Impact
Vanhaesebroeck et al., London, United Kingdom. In Nat Immunol, 2012
Lipopolysaccharide activates plasma-membrane signaling and endosomal signaling by Toll-like receptor 4 (TLR4) through the TIRAP-MyD88 and TRAM-TRIF adaptor complexes, respectively, but it is unclear how the signaling switch between these cell compartments is coordinated.
Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A.
GeneRIF
Lagna et al., Boston, United States. In J Biol Chem, 2012
molecular inhibitory pathway linking BMP4 signaling, activation of MRTF-A, and inhibition of NF-kappaB provides insights into the etiology of PAH and a potential focus of therapeutic intervention.
Poxviral protein A46 antagonizes Toll-like receptor 4 signaling by targeting BB loop motifs in Toll-IL-1 receptor adaptor proteins to disrupt receptor:adaptor interactions.
GeneRIF
Bowie et al., Dublin, Ireland. In J Biol Chem, 2012
Poxviral protein A46 inhibits TLR4 signaling and interacts with Toll-IL-1 receptor (TIR) domain-containing proteins of the receptor complex.
Toll-like receptor signal adaptor protein MyD88 is required for sustained endotoxin-induced acute hypoferremic response in mice.
GeneRIF
Santos et al., Montréal, Canada. In Am J Pathol, 2012
Toll-like receptor signal adaptor protein MyD88 is required for sustained endotoxin-induced acute hypoferremic response in mice.
Phosphoinositide binding by the Toll adaptor dMyD88 controls antibacterial responses in Drosophila.
Impact
Kagan et al., Boston, United States. In Immunity, 2012
These data are reminiscent of the interactions between the mammalian Toll adaptors MyD88 and TIRAP with one major exception.
MAL facilitates the incorporation of exocytic uroplakin-delivering vesicles into the apical membrane of urothelial umbrella cells.
GeneRIF
Sun et al., New York City, United States. In Mol Biol Cell, 2012
the exclusion of MAL from the expanding 2D crystals of uroplakins explains the selective association of MAL with the hinge areas in the uroplakin-delivering fusiform vesicles, as well as at the apical surface
The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils.
Impact
Morio et al., Tokyo, Japan. In Nat Immunol, 2012
In the absence of Btk, the adaptor Mal was associated with PI(3)K and PTKs at the plasma membrane, whereas in control resting neutrophils, Btk interacted with and confined Mal in the cytoplasm.
Structural insights into TIR domain specificity of the bridging adaptor Mal in TLR4 signaling.
GeneRIF
Shen et al., Tianjin, China. In Plos One, 2011
The Mal-Toll/interleukin-1 receptor (TIR) domains AB loop is capable of mediating direct binding to the TIR domains of TLR4 and MyD88 simultaneously.
Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype.
Impact
Karsan et al., Vancouver, Canada. In Nat Med, 2010
We show that deletion of chromosome 5q correlates with loss of two miRNAs that are abundant in hematopoietic stem/progenitor cells (HSPCs), miR-145 and miR-146a, and we identify Toll-interleukin-1 receptor domain-containing adaptor protein (TIRAP) and tumor necrosis factor receptor-associated factor-6 (TRAF6) as respective targets of these miRNAs.
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