Mal, more than a bridge to MyD88.
Dublin, Ireland. In Iubmb Life, Sep 2013
This review will focus on one of those adaptors, MyD88 adaptor-like (Mal), also known as TIRAP.
RAGE in tissue homeostasis, repair and regeneration.
Perugia, Italy. In Biochim Biophys Acta, 2013
Upon RAGE ligation, adaptor proteins (i.e., diaphanous-1, TIRAP, MyD88 and/or other as yet unidentified adaptors) associate with RAGE cytoplasmic domain resulting in signaling.
[Negative regulation of Toll-like receptor signalling].
Lublin, Poland. In Postepy Hig Med Dosw (online), 2012
MyD88, TIRAP, TRIF, TRAM, and IPS-1, which participate in the cascade activation of kinases (IKK, MAP, RIP-1, TBK-1) as well as transcription factors (NF-κB, AP-1) and regulatory factor (IRF3).
Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype.
Vancouver, Canada. In Nat Med, 2010
We show that deletion of chromosome 5q correlates with loss of two miRNAs that are abundant in hematopoietic stem/progenitor cells (HSPCs), miR-145 and miR-146a, and we identify Toll-interleukin-1 receptor domain-containing adaptor protein (TIRAP) and tumor necrosis factor receptor-associated factor-6 (TRAF6) as respective targets of these miRNAs.