gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 03 Sep 2015.

Toll-interleukin 1 receptor

Mal, TIRAP, BSAC, Wyatt
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MyD88, TLR4, CAN, TLR2, TRAM
Papers on Mal
Two Mechanisms Determine the Barber-Pole Illusion.
New
Chubb et al., In J Vis, 01 Oct 2015
(2) Reverse-phi barberpole stimuli are seen exclusively in the forward (feature, third-order) BPI direction when presented at 2.75 Hz and exclusively in the opposite (Fourier, first-order) BPI direction at 21.5 Hz. (3) The BPI in barber poles with scalloped edges (Badcock, McKendrick, and Ma-Wyatt, VisRes, 2003) is much weaker than in normal straight-edge barber poles for 2.75 Hz stimuli but not in 21.5 Hz stimuli.
Cisplatin-Induced Formation of Biocompatible and Biodegradable Polypeptide-Based Vesicles for Targeted Anticancer Drug Delivery.
New
Qiao et al., Melbourne, Australia. In Biomacromolecules, 10 Sep 2015
These vesicles were formed from biocompatible and biodegradable maleimide-poly(ethylene oxide)114-b-poly(L-glutamic acid)12 (Mal-PEG114-b-PLG12) block copolymers upon conjugation with the drug itself.
Toll-Like Receptor Gene Expression during Trichinella spiralis Infection.
New
Yu et al., Yangsan, South Korea. In Korean J Parasitol, 31 Aug 2015
In addition, the expression of several chemokine- and cytokine-encoding genes, which are related to Th2 and Treg cell mediated immune responses, were analyzed in mouse embryonic fibroblasts (MEFs) isolated from myeloid differentiation factor 88 (MyD88)/TIR-associated proteins (TIRAP) and Toll receptor-associated activator of interferons (TRIF) adapter protein deficient and wild type (WT) mice.
Identification of genetic variation exclusive to specific lineages associated with Staphylococcus aureus bacteraemia.
New
Desai et al., Bristol, United Kingdom. In J Hosp Infect, 30 Aug 2015
AIM: To investigate the distribution and nucleotide sequence of heterogeneous regions between successful lineages using the 2009 British Society for Antimicrobial Chemotherapy (BSAC) Bacteraemia Resistance Surveillance Programme collection of S. aureus.
Toll-like receptor signalling through macromolecular protein complexes.
Review
New
Gay et al., Cambridge, United Kingdom. In Mol Immunol, Feb 2015
Toll-like receptor 4 (TLR4) signals through two separate pairs of adaptor proteins Mal/MyD88 and Tram/Trif.
The Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway.
New
Nussinov et al., İstanbul, Turkey. In Sci Rep, Dec 2014
The architecture that we obtain with 8 MyD88 molecules provides the structural basis for the MyD88-templated myddosome helical assembly and receptor clustering; it also provides clues to pro- and anti-inflammatory signaling pathways branching at the signalosome level to Mal/MyD88 and TRAM/TRIF pro- and anti-inflammatory pathways.
TLR2 and TLR4 in autoimmune diseases: a comprehensive review.
Review
New
Lu et al., Changsha, China. In Clin Rev Allergy Immunol, Oct 2014
There are five adaptors to TLRs including MyD88, TRIF, TIRAP/MAL, TRAM, and SARM.
Antiretroviral therapy and the kidney.
Review
New
Wyatt, New York City, United States. In Top Antivir Med, Jun 2014
This article summarizes a presentation by Christina M. Wyatt, MD, at the IAS-USA continuing education program held in Washington, DC, in June 2013.
A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction.
New
Impact
Kagan et al., Boston, United States. In Cell, Mar 2014
Here, we report that, in response to natural activators of innate immunity, the sorting adaptor TIRAP regulates TLR signaling from the plasma membrane and endosomes.
Clinical relevance of mupirocin resistance in Staphylococcus aureus.
Review
Bonten et al., Utrecht, Netherlands. In J Hosp Infect, 2013
EUCAST and BSAC clinical thresholds for S. aureus are ≤1mg/L for susceptible and >256mg/L for resistant, placing the susceptible threshold at the epidemiological cut-off value (ECOFF).
Toll-like receptors' pathway disturbances are associated with increased susceptibility to infections in humans.
Review
Condino-Neto et al., São Paulo, Brazil. In Arch Immunol Ther Exp (warsz), 2013
TLRs and IL-1R are a family of receptors related to the innate immune response that contain an intracellular domain known as the Toll-IL-1R (TIR) domain that recruits the TIR-containing cytosolic adapters MyD88, TRIF, TIRAP and TRAM.
The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.
Impact
Vanhaesebroeck et al., London, United Kingdom. In Nat Immunol, 2012
Lipopolysaccharide activates plasma-membrane signaling and endosomal signaling by Toll-like receptor 4 (TLR4) through the TIRAP-MyD88 and TRAM-TRIF adaptor complexes, respectively, but it is unclear how the signaling switch between these cell compartments is coordinated.
Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A.
GeneRIF
Lagna et al., Boston, United States. In J Biol Chem, 2012
molecular inhibitory pathway linking BMP4 signaling, activation of MRTF-A, and inhibition of NF-kappaB provides insights into the etiology of PAH and a potential focus of therapeutic intervention.
Poxviral protein A46 antagonizes Toll-like receptor 4 signaling by targeting BB loop motifs in Toll-IL-1 receptor adaptor proteins to disrupt receptor:adaptor interactions.
GeneRIF
Bowie et al., Dublin, Ireland. In J Biol Chem, 2012
Poxviral protein A46 inhibits TLR4 signaling and interacts with Toll-IL-1 receptor (TIR) domain-containing proteins of the receptor complex.
Toll-like receptor signal adaptor protein MyD88 is required for sustained endotoxin-induced acute hypoferremic response in mice.
GeneRIF
Santos et al., Montréal, Canada. In Am J Pathol, 2012
Toll-like receptor signal adaptor protein MyD88 is required for sustained endotoxin-induced acute hypoferremic response in mice.
Phosphoinositide binding by the Toll adaptor dMyD88 controls antibacterial responses in Drosophila.
Impact
Kagan et al., Boston, United States. In Immunity, 2012
These data are reminiscent of the interactions between the mammalian Toll adaptors MyD88 and TIRAP with one major exception.
MAL facilitates the incorporation of exocytic uroplakin-delivering vesicles into the apical membrane of urothelial umbrella cells.
GeneRIF
Sun et al., New York City, United States. In Mol Biol Cell, 2012
the exclusion of MAL from the expanding 2D crystals of uroplakins explains the selective association of MAL with the hinge areas in the uroplakin-delivering fusiform vesicles, as well as at the apical surface
The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils.
Impact
Morio et al., Tokyo, Japan. In Nat Immunol, 2012
In the absence of Btk, the adaptor Mal was associated with PI(3)K and PTKs at the plasma membrane, whereas in control resting neutrophils, Btk interacted with and confined Mal in the cytoplasm.
Structural insights into TIR domain specificity of the bridging adaptor Mal in TLR4 signaling.
GeneRIF
Shen et al., Tianjin, China. In Plos One, 2011
The Mal-Toll/interleukin-1 receptor (TIR) domains AB loop is capable of mediating direct binding to the TIR domains of TLR4 and MyD88 simultaneously.
Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype.
Impact
Karsan et al., Vancouver, Canada. In Nat Med, 2010
We show that deletion of chromosome 5q correlates with loss of two miRNAs that are abundant in hematopoietic stem/progenitor cells (HSPCs), miR-145 and miR-146a, and we identify Toll-interleukin-1 receptor domain-containing adaptor protein (TIRAP) and tumor necrosis factor receptor-associated factor-6 (TRAF6) as respective targets of these miRNAs.
share on facebooktweetadd +1mail to friends