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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Toll-interleukin 1 receptor

Mal, TIRAP, BSAC, Wyatt
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MyD88, TLR4, CAN, TLR2, TRAM
Papers on Mal
Change in size, morphology and stability of DNA polyplexes with hyperbranched poly(ethyleneimines) containing bulky maltose units.
New
Koetz et al., Potsdam, Germany. In Colloids Surf B Biointerfaces, 01 Mar 2016
Polyplexes between Salmon DNA and non-modified hyperbranched poly(ethyleneimines) of varying molar mass, i.e., PEI(5k) with 5000g/mol and PEI(25k) with 25,000g/mol, and modified PEI(5k) with maltose units (PEI-Mal) were investigated in dependence on the molar N/P ratio by using dynamic light scattering (DLS), zeta potential measurements, micro differential scanning calorimetry (μ-DSC), scanning-transmission electron microscopy (STEM), and cryo-scanning electron microscopy (cryo-SEM).
Does mouse embryo primordial germ cell activation start before implantation as suggested by single-cell transcriptomics dynamics?
New
Araúzo-Bravo et al., San Sebastián, Spain. In Mol Hum Reprod, 05 Feb 2016
We also identified new transitory E3.5 EPI markers (Sgk1, Mal, Ubxn2a, Atg16l2, Gm13102, Tcfap2c, Hexb, Slc1a1, Svip, Liph and Mier3), six new stable PE markers (Sdc4, Cpn1, Dkk1, Havcr1, F2r/Par1 and Slc7a6os) as well as three new stable EPI markers (Zp3, Mcf2 and Hexb), which are known to be late stage germ cell markers.
The Golgi-Associated Plant Pathogenesis-Related Protein GAPR-1 Enhances Type I Interferon Signaling Pathway in Response to Toll-Like Receptor 4.
New
Cai et al., Shenzhen, China. In Inflammation, 17 Jan 2016
UNASSIGNED: Lipopolysaccharide (LPS) activates Toll-like receptor 4 (TLR4) through the TIRAP-MyD88 dependent and TRAM-TRIF dependent signaling pathways, respectively.
Stable Evans Blue Derived Exendin-4 Peptide for Type 2 Diabetes Treatment.
New
Chen et al., Changchun, China. In Bioconjug Chem, 10 Jan 2016
In this work, we synthesized a maleimide derivative of truncated Evans blue dye (MEB-C3-Mal) to conjugate with (Cys(40))exendin-4 to obtain a highly stable MEB-C3-(Cys(40))exendin-4 (denoted as Abextide II).
Bulk Segregant Analysis Reveals the Genetic Basis of a Natural Trait Variation in Fission Yeast.
New
Du et al., Beijing, China. In Genome Biol Evol, 31 Dec 2015
To assess the feasibility of segregant-pool-based mapping of phenotype-causing genes in natural strains of fission yeast, we investigated the cause of a maltose utilization defect (Mal(-)) of the S. pombe strain CBS5557 (originally known as Schizosaccharomyces malidevorans).
Recovery Trends of Commercial Fish: The Case of an Underperforming Mediterranean Marine Protected Area.
New
de Lucia et al., Oristano, Italy. In Plos One, 31 Dec 2015
The effects of protection on the fish assemblages of the sublittoral rocky reefs in the "Penisola del Sinis-Isola di Mal di Ventre" MPA (W.
Alitretinoin: treatment for refractory palmoplantar keratoderma.
New
Ko et al., Seoul, South Korea. In Br J Dermatol, 30 Dec 2015
UNASSIGNED: Mal de Meleda (MDM) is an autosomal recessive form of palmoplantar keratoderma caused by mutations in the ARS gene, encoding SLURP-1.(1)
Suppression of MAL gene expression is associated with colorectal cancer metastasis.
New
Peng et al., Xi'an, China. In Oncol Lett, Aug 2015
UNASSIGNED: Mal, T-cell differentiation protein (MAL) is a candidate tumor suppressor gene that functions in membrane trafficking processes in polarized epithelial cells.
Olmsted syndrome: clinical, molecular and therapeutic aspects.
Review
Hovnanian et al., Paris, France. In Orphanet J Rare Dis, 2014
OS has to be differentiated from other severe forms of PPK including Vohwinkel, Clouston, Papillon-Lefèvre or Haim-Munk syndromes, Mal de Meleda, pachyonychia congenita, Tyrosinemia type II and acrodermatitis enteropathica.
Brazilian Red Propolis Attenuates Inflammatory Signaling Cascade in LPS-Activated Macrophages.
Mayer et al., São Paulo, Brazil. In Plos One, 2014
Furthermore, the upstream adaptor MyD88 adaptor-like (Mal), also known as TIRAP, involved in TLR2 and TLR4 signaling, was down- regulated in BRP treated LPS-activated macrophages.
A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction.
Impact
Kagan et al., Boston, United States. In Cell, 2014
Here, we report that, in response to natural activators of innate immunity, the sorting adaptor TIRAP regulates TLR signaling from the plasma membrane and endosomes.
The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.
Impact
Vanhaesebroeck et al., London, United Kingdom. In Nat Immunol, 2012
Lipopolysaccharide activates plasma-membrane signaling and endosomal signaling by Toll-like receptor 4 (TLR4) through the TIRAP-MyD88 and TRAM-TRIF adaptor complexes, respectively, but it is unclear how the signaling switch between these cell compartments is coordinated.
Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A.
GeneRIF
Lagna et al., Boston, United States. In J Biol Chem, 2012
molecular inhibitory pathway linking BMP4 signaling, activation of MRTF-A, and inhibition of NF-kappaB provides insights into the etiology of PAH and a potential focus of therapeutic intervention.
Poxviral protein A46 antagonizes Toll-like receptor 4 signaling by targeting BB loop motifs in Toll-IL-1 receptor adaptor proteins to disrupt receptor:adaptor interactions.
GeneRIF
Bowie et al., Dublin, Ireland. In J Biol Chem, 2012
Poxviral protein A46 inhibits TLR4 signaling and interacts with Toll-IL-1 receptor (TIR) domain-containing proteins of the receptor complex.
Toll-like receptor signal adaptor protein MyD88 is required for sustained endotoxin-induced acute hypoferremic response in mice.
GeneRIF
Santos et al., Montréal, Canada. In Am J Pathol, 2012
Toll-like receptor signal adaptor protein MyD88 is required for sustained endotoxin-induced acute hypoferremic response in mice.
Phosphoinositide binding by the Toll adaptor dMyD88 controls antibacterial responses in Drosophila.
Impact
Kagan et al., Boston, United States. In Immunity, 2012
These data are reminiscent of the interactions between the mammalian Toll adaptors MyD88 and TIRAP with one major exception.
MAL facilitates the incorporation of exocytic uroplakin-delivering vesicles into the apical membrane of urothelial umbrella cells.
GeneRIF
Sun et al., New York City, United States. In Mol Biol Cell, 2012
the exclusion of MAL from the expanding 2D crystals of uroplakins explains the selective association of MAL with the hinge areas in the uroplakin-delivering fusiform vesicles, as well as at the apical surface
The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils.
Impact
Morio et al., Tokyo, Japan. In Nat Immunol, 2012
In the absence of Btk, the adaptor Mal was associated with PI(3)K and PTKs at the plasma membrane, whereas in control resting neutrophils, Btk interacted with and confined Mal in the cytoplasm.
Structural insights into TIR domain specificity of the bridging adaptor Mal in TLR4 signaling.
GeneRIF
Shen et al., Tianjin, China. In Plos One, 2011
The Mal-Toll/interleukin-1 receptor (TIR) domains AB loop is capable of mediating direct binding to the TIR domains of TLR4 and MyD88 simultaneously.
Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype.
Impact
Karsan et al., Vancouver, Canada. In Nat Med, 2010
We show that deletion of chromosome 5q correlates with loss of two miRNAs that are abundant in hematopoietic stem/progenitor cells (HSPCs), miR-145 and miR-146a, and we identify Toll-interleukin-1 receptor domain-containing adaptor protein (TIRAP) and tumor necrosis factor receptor-associated factor-6 (TRAF6) as respective targets of these miRNAs.
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